Antioxidant status and lipoprotein peroxidation in chronic fatigue syndrome

Keenoy, Begoña Manuel y; Moorkens, Greta; Vertommen, J.; Leeuw, I. De

doi:10.1016/s0024-3205(01)01001-3

Cited by 79 publications

(30 citation statements)

References 35 publications

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“…An important contributor to fatigue is oxidative damage to mitochondrial membrane lipids. This increases inner membrane leakiness and lowers trans-membrane potential of the inner mitochondrial membrane (MIM), thus impairing mitochondrial function and production of ATP, resulting in reduced physical and mental performance with aging and disease [20] [24]- [26]. For example, chronic fatigue syndrome patients present with evidence of oxidative damage to DNA and lipids [26] [27], such as oxidized blood markers and oxidized membrane lipids that are indicative of excess oxidative stress [27] [28].…”

Section: Clinical Uses Of Membrane Lipid Replacement-fatiguementioning

confidence: 99%

“…This increases inner membrane leakiness and lowers trans-membrane potential of the inner mitochondrial membrane (MIM), thus impairing mitochondrial function and production of ATP, resulting in reduced physical and mental performance with aging and disease [20] [24]- [26]. For example, chronic fatigue syndrome patients present with evidence of oxidative damage to DNA and lipids [26] [27], such as oxidized blood markers and oxidized membrane lipids that are indicative of excess oxidative stress [27] [28]. These patients also have sustained, elevated levels of peroxynitrite due to excess nitric oxide, which can also result in lipid peroxidation and loss of mitochondrial function as well as changes in cytokine levels that exert a positive feedback on nitric oxide production [29].…”

Section: Clinical Uses Of Membrane Lipid Replacement-fatiguementioning

confidence: 99%

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Membrane Lipid Replacement: Clinical Studies Using a Natural Medicine Approach to Restoring Membrane Function and Improving Health

Nicolson¹

2016

IJCM

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Section: Clinical Uses Of Membrane Lipid Replacement-fatiguementioning

confidence: 99%

Section: Clinical Uses Of Membrane Lipid Replacement-fatiguementioning

confidence: 99%

Membrane Lipid Replacement: Clinical Studies Using a Natural Medicine Approach to Restoring Membrane Function and Improving Health

Nicolson¹

2016

IJCM

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“…Whereas sport practice induces a moderate oxidative stress in healthy subjects [9], a strong exercise-induced production of reactive oxygen species (ROS) is found in ME/CFS patients [10–14]. The antioxidant response is also altered at rest, as shown by an increased level of the thiobarbituric acid reactive substances (TBARS: a marker of lipid peroxidation) and a decreased concentration of the reduced ascorbic acid marker (RAA: an endogenous antioxidant) [10, 13, 14].…”

Section: Introductionmentioning

confidence: 99%

“…The antioxidant response is also altered at rest, as shown by an increased level of the thiobarbituric acid reactive substances (TBARS: a marker of lipid peroxidation) and a decreased concentration of the reduced ascorbic acid marker (RAA: an endogenous antioxidant) [10, 13, 14]. Because the increased ROS production affects the muscle excitability [15, 16], the increased redox stress in ME/CFS may participate to the muscle fatigue as evidenced via an alteration of the compound evoked muscle action potential (M-wave) [10].…”

Section: Introductionmentioning

confidence: 99%

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Association of biomarkers with health-related quality of life and history of stressors in myalgic encephalomyelitis/chronic fatigue syndrome patients

et al. 2016

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BackgroundMyalgic encephalomyelitis chronic fatigue syndrome (ME/CFS) is a common debilitating disorder associated with an intense fatigue, a reduced physical activity, and an impaired quality of life. There are no established biological markerof the syndrome. The etiology is unknown and its pathogenesis appears to be multifactorial. Various stressors, including intense physical activity, severe infection, and emotional stress are reported in the medical history of ME/CFS patients which raises the question whether any physiological and biological abnormalities usually found in these patients could be indicative of the etiology and/or the quality-of-life impairment.MethodsThirty-six patients and 11 age-matched healthy controls were recruited. The following variables that appear to address common symptoms of ME/CFS were studied here: (1) muscle fatigue during exercise has been investigated by monitoring the compound muscle action potential (M-wave); (2) the excessive oxidative stress response to exercise was measured via two plasma markers (thiobarbituric acid reactive substances: TBARS; reduced ascorbic-acid: RAA); (3) a potential inflammatory component was addressed via expression of CD26 on peripheral blood mononuclear cells; (4) quality-of-life impairment was assessed using the London Handicap Scale (LHS) and the Medical Outcome Study Short Form-36 (SF-36). The medical history of each patient, including the presence of stressors such as intense sports practice, severe acute infection and/or severe emotional stress was documented.ResultsWe observed that: (1) there were striking differences between cases and controls with regard to three biological variables: post-exercise M-wave, TBARS variations and CD26-expression at rest; (2) each of these three variables correlated with the other two; (3) abnormalities in the biomarkers associated with health-related quality of life: the LHS score was negatively correlated with the exercise-induced TBARS increase and positively correlated with CD26-expression while the pain component of SF-36 was negatively correlated with CD26-expression; (4) the TBARS increase and the M-wave decrease were the highest, and the CD26-expression level the lowest in patients who had been submitted to infectious stressors.ConclusionIn ME/CFS patients, severe alterations of the muscle excitability, the redox status, as well as the CD26-expression level are correlated with a marked impairment of the quality-of-life. They are particularly significant when infectious stressors are reported in the medical history.

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Metabolic syndrome and mitochondrial function: Molecular replacement and antioxidant supplements to prevent membrane peroxidation and restore mitochondrial function

Nicolson

2007

J of Cellular Biochemistry

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Metabolic syndrome consists of a cluster of metabolic conditions, such as hypertriglyceridemia, hyper-low-density lipoproteins, hypo-high-density lipoproteins, insulin resistance, abnormal glucose tolerance and hypertension, that-in combination with genetic susceptibility and abdominal obesity-are risk factors for type 2 diabetes, vascular inflammation, atherosclerosis, and renal, liver and heart disease. One of the defects in metabolic syndrome and its associated diseases is excess cellular oxidative stress (mediated by reactive oxygen and nitrogen species, ROS/RNS) and oxidative damage to mitochondrial components, resulting in reduced efficiency of the electron transport chain. Recent evidence indicates that reduced mitochondrial function caused by ROS/RNS membrane oxidation is related to fatigue, a common complaint of MS patients. Lipid replacement therapy (LRT) administered as a nutritional supplement with antioxidants can prevent excess oxidative membrane damage, restore mitochondrial and other cellular membrane functions and reduce fatigue. Recent clinical trials have shown the benefit of LRT plus antioxidants in restoring mitochondrial electron transport function and reducing moderate to severe chronic fatigue. Thus LRT plus antioxidant supplements should be considered for metabolic syndrome patients who suffer to various degrees from fatigue.

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Antioxidant status and lipoprotein peroxidation in chronic fatigue syndrome

Cited by 79 publications

References 35 publications

Membrane Lipid Replacement: Clinical Studies Using a Natural Medicine Approach to Restoring Membrane Function and Improving Health

Membrane Lipid Replacement: Clinical Studies Using a Natural Medicine Approach to Restoring Membrane Function and Improving Health

Association of biomarkers with health-related quality of life and history of stressors in myalgic encephalomyelitis/chronic fatigue syndrome patients

Metabolic syndrome and mitochondrial function: Molecular replacement and antioxidant supplements to prevent membrane peroxidation and restore mitochondrial function

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