Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage

Maldonado, Perla D.; Barrera, Diana; Rivero, Isabel; Mata, Rachel; Medina-Campos, Omar Noel; Hernández-Pando, Rogelio; Pedraza‐Chaverrí, José

doi:10.1016/s0891-5849(03)00312-5

Cited by 156 publications

(113 citation statements)

References 53 publications

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“…In another study, Maldonado et al have investigated the antioxidant effects of garlic in experimental animal models by inducing nephrotoxicity with gentamicin. They reported that aged garlic extracts prevented an increase in carbonyl and nitrotyrosine levels in the renal cortex, and that the extracts also precluded a decrease in the activity of antioxidant enzymes (manganese-containing superoxide dismutase, glutathione peroxidase, glutathione reductase) (6).…”

Section: Discussionmentioning

confidence: 99%

Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats

et al. 2014

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ARTICLE INFO ______________________________________________________________ ______________________Purpose: To demonstrate the effect of a 4% pulverized garlic supplemented diet on the nephrotoxicity induced by gentamicin in rats. Materials and Methods: Twenty four healthy male Wistar rats, weighing between 220 -260grams, were divided into three groups. The rats were randomly assigned to either the gentamicin injection without garlic supplementation group (Group I, n = 8), gentamicin injection with garlic supplementation group (Group II, n = 8), and control group (Group III, n = 8). Urine from the rats was collected and the volume (mLand pH values were measured. Then urea (mg/dL), creatinine (mg/dL), total protein (g/dL) and cystatin (mg/L) values were measured for the blood samples obtained from tail veins. Results:The median NAG value for the control group (52.050 U/L) was similar to value for Group II (56.400 U/L), which received gentamicin and the garlic diet. However, the median NAG value for Group I (77.030 U/L), which received gentamicin without garlic supplementation, was determined to be statistically significantly higher (p = 0.010) than the value for the control group. In addition, the mean cystatin value for Group II (1.360 U/L) was found to be statistically significantly lower than the value for the Group I (2.240 U/L) (p = 0.015).Conclusions: In this study we showed the effect of 4% pulverized garlic supplemented diet for preventing nephrotoxicity induced by gentamicin in rats by using as parameters NAG in urine samples and cystatin C in serum samples.

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Section: Discussionmentioning

confidence: 99%

Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats

et al. 2014

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“…Phenolic compounds present in medicinal plants have been reported to possess powerful antioxidants activity (Maldonadu et al ., 2003). Grape seeds are rich sources of monomeric phenolic compounds such as catechin, epicatechin and dimeric, trimeric and tetrameric proanthocyanidins (Shin et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

Inhibitory Effects of Grape Seeds Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats

Nagib

2014

Egyptian Journal of Nutrition and Health

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This study was designed to determine the Inhibitory effect of grape seeds powder, extract and oil on gentamicin-induced nephrotoxicity in rats.The study was carried out on 30 adult albino male rats Sprague-Dawley strain were classified into two groups: The first group (n= 6) left as normal control group(-ve), fed on basal diet, the second group(n= 24) injected with gentamicin (100 mg/kg/day for 7 days i.p). These animals were divided into 4 groups 6 rats each of these , control (+ve) group and 3 groups were treated with grape seeds powder ( 10 % of diet ) , grape seeds extract (300mg/kg b.w.orally by stomach tube) and grape seeds oil (4 ml/kg b.w. orally by stomach tube) respectively.The treatment period was designed for eight weeks. The results revealed that, Gentamicin injection induced marked nephrotoxicity as evidenced by significant elevation in serum levels of creatinine, urea, uric acid, A/G ratio, MDA ,renin hormone, phosphorus and potassium, with significant reduction in serum levels of total protein, albumin, globulin, (SOD), (GPX), (GST) ,catalase antioxidant enzymes, erythropoietin hormone (EPO) , vitamin D and Ca . While the rat groups treated with grape seeds powder ,extract and oil showed significant improvement of the levels of serum total protein, albumin, globulin, kidney tissue superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione transferase (GST) , catalase antioxidant enzymes, erythropoietin hormone (EPO) and vitamin D, and significant decrease in serum creatinine, urea, uric acid, albumin/globulin ratio ,kidney tissue malondialdehyde (MDA), renin hormone, phosphorus and potassium compared with control(+ve) group. In conclusion, feeding rats with grape seeds powder ,extract and oil may significantly reduce nephrotoxicity, So this study recommend the use of grape seeds especially grape seeds oil or grape seeds extract for humans suffering nephrotoxicity, could be of value.

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“…SAC is the most abundant compound in aged garlic and has strong anti-oxidant activity (COLIN-GONZALEZ et al, 2015). At the cellular level, reactive oxygen species (ROS), including superoxide radical and hydrogen peroxide (H 2 O 2 ), are reduced by SAC treatment LAU, 2001;MALDONADO et al, 2003). SAC can scavenge superoxide radical and reduce hydrogen peroxide production (COLIN-GONZALEZ et al, 2012;MEDINA-CAMPO et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Supplementation of S-allyl cysteine improves health span in Caenorhabditis elegans

Kim¹

2017

Biosci. J.

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Previous studies show that nutritional interventions with anti-oxidants have various healthpromoting effects in several model organisms. Here, we examine the effects of S-allyl cysteine on resistance to environmental stressors and age-related physiological changes using C. elegans as a model system. S-allyl cysteine is a modified amino acid found in aged garlic extracts and known to have strong anti-oxidant activity. The survival of worms under oxidative-stress conditions significantly increased with supplementation of S-allyl cysteine. In addition, pretreatment of S-allyl cysteine significantly increased resistance to both heat stress and ultraviolet irradiation. However, lifespan was not affected by S-allyl cysteine treatment. We also examined the effect of S-allyl cysteine on motility of C. elegans and found that S-allyl cysteine can retard the age-related decline of muscle tissue locomotive activity. S-allyl cysteine also significantly suppressed amyloid β-induced paralysis in Alzheimer's disease model animals. Taken together, our study indicates that dietary supplementation of S-allyl cysteine can improve health span and suggests that S-allyl cysteine can be used to develop novel health-promoting pharmaceuticals.

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Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage

Cited by 156 publications

References 53 publications

Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats

Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats

Inhibitory Effects of Grape Seeds Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats

Supplementation of S-allyl cysteine improves health span in Caenorhabditis elegans

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