Antioxidant responses, hepatic intermediary metabolism, histology and ultrastructure in Synechogobius hasta exposed to waterborne cadmium

Liu, X.-J.; Luo, Zhi; Li, C.-H.; Xiong, Bo; Zhao, Yuxin; Li, X.-D.

doi:10.1016/j.ecoenv.2011.02.015

Cited by 70 publications

(36 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mitochondria is a major site of the generation of cellular ROS (Martínez-Reyes and Cuezva, 2014), its damage would result in the polarization of mitochondrial membrane and increases the production of ROS (Korshunov et al, 1997). The increase in LPO and PC caused by Cd in the liver of zebrafish would support this notion, agreement with the reports in Cd exposed fish (Li et al, 2010;Liu et al, 2011;Nunes et al, 2015). On the contrary, chronic Zn exposure reduced hepatic oxidative damage.…”

Section: Discussionsupporting

confidence: 81%

“…Thus, fish liver is a very interesting model for the study of interactions between environmental factors and hepatic functions. Under Cd stress, there were tremendous alterations of hepatocellular structure such as severe pyknotic nuclei, considerable lipid inclusions, the swelling and vesiculation of mitochondria with disappeared cristae, and absence of rough endoplasmic reticulum, similar to the reports about effects of metal exposure on alterations of histology and and ultrastructure in fish (Barillet et al, 2010;Lee et al, 2014;Liu et al, 2011;Song et al, 2016). Unlike Cd exposure, Zn weakly induced changes in hepatocellular structure.…”

Section: Discussionsupporting

confidence: 76%

See 1 more Smart Citation

Chronic waterborne zinc and cadmium exposures induced different responses towards oxidative stress in the liver of zebrafish

et al. 2016

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 76%

Chronic waterborne zinc and cadmium exposures induced different responses towards oxidative stress in the liver of zebrafish

et al. 2016

View full text Add to dashboard Cite

“…All other studies used bioassays to measure SOD activity in liver, gills, muscle, intestine, kidney, red blood cells, blood, spleen and whole fish. SOD activity in gill tissue decreased in all studies, irrespective of exposure to mixed metals in field studies or single metal in laboratory toxicity tests [49, 84, 110, 117]. Following Cd exposure in toxicity tests, responses in different tissues have been consistent across various tissues (e.g.…”

Section: Resultsmentioning

confidence: 94%

A protocol for identifying suitable biomarkers to assess fish health: A systematic review

2017

View full text Add to dashboard Cite

BackgroundBiomarkers have been used extensively to provide the connection between external levels of contaminant exposure, internal levels of tissue contamination, and early adverse effects in organisms.ObjectivesTo present a three-step protocol for identifying suitable biomarkers to assess fish health in coastal and marine ecosystems, using Gladstone Harbour (Australia) as a case study.MethodsPrior to applying our protocol, clear working definitions for biomarkers were developed to ensure consistency with the global literature on fish health assessment. First, contaminants of concern were identified based on the presence of point and diffuse sources of pollution and available monitoring data for the ecosystem of interest. Second, suitable fish species were identified using fisheries dependent and independent data, and prioritised based on potential pathways of exposure to the contaminants of concern. Finally, a systematic and critical literature review was conducted on the use of biomarkers to assess the health of fish exposed to the contaminants of concern.Results/DiscussionWe present clear working definitions for bioaccumulation markers, biomarkers of exposure, biomarkers of effect and biomarkers of susceptibility. Based on emission and concentration information, seven metals were identified as contaminants of concern for Gladstone Harbour. Twenty out of 232 fish species were abundant enough to be potentially suitable for biomarker studies; five of these were prioritised based on potential pathways of exposure and susceptibility to metals. The literature search on biomarkers yielded 5,035 articles, of which 151met the inclusion criteria. Based on our review, the most suitable biomarkers include bioaccumulation markers, biomarkers of exposure (CYP1A, EROD, SOD, LPOX, HSP, MT, DNA strand breaks, micronuclei, apoptosis), and biomarkers of effect (histopathology, TAG:ST).ConclusionOur protocol outlines a clear pathway to identify suitable biomarkers to assess fish health in coastal and marine ecosystems, which can be applied to biomarker studies in aquatic ecosystems around the world.

show abstract

“…Biochemical and genotoxicity analysis demonstrated alterations of enzymes involved in antioxidant defenses and nervous system, as well as damages in lipids, proteins, and DNA. These responses were correlated to the bioavailability of metals and PAHs, which induce several lesions and alterations in target tissues, as described by Liu et al (2010Liu et al ( , 2011.…”

Section: Different Biomarkers Showed That the Health Of Fish Is Comprmentioning

confidence: 97%

Bioavailability of pollutants sets risk of exposure to biota and human population in reservoirs from Iguaçu River (Southern Brazil)

Yamamoto

Pereira

Lottermann

et al. 2016

Environ Sci Pollut Res

View full text Add to dashboard Cite

The Iguaçu River, located at the Southern part of Brazil, has a great socioeconomic and environmental importance due to its high endemic fish fauna and its potential to generate hydroelectric power. However, Iguaçu River suffers intense discharge of pollutants in the origin of the river. In a previous report, the local environmental agency described water quality to improve along the river course. However, no study with integrated evaluation of chemical analysis and biological responses has been reported so far for the Iguaçu River. In the current study, three different Brazilian fish species (Astyanax bifasciatus, Chrenicicla iguassuensis, and Geophagus brasiliensis) were captured in the five cascading reservoirs of Iguaçu River for a multi-biomarker study. Chemical analysis in water, sediment, and muscle indicated high levels of bioavailable metals in all reservoirs. Polycyclic aromatic hydrocarbons (PAHs) were detected in the bile of the three fish species. Integration of the data through a FA/PCA analysis demonstrated the poorest environmental quality of the reservoir farthest from river's source, which is the opposite of what has been reported by the environmental agency. The presence of hazardous chemicals in the five reservoirs of Iguaçu River, their bioaccumulation in the muscle of fish, and the biological responses showed the impacts of human activities to this area and did not confirm a gradient of pollution between the five reservoirs, from the source toward Iguaçu River's mouth. Therefore, diffuse source of pollutants present along the river course are increasing the risk of exposure to biota and human populations.

show abstract

Antioxidant responses, hepatic intermediary metabolism, histology and ultrastructure in Synechogobius hasta exposed to waterborne cadmium

Cited by 70 publications

References 46 publications

Chronic waterborne zinc and cadmium exposures induced different responses towards oxidative stress in the liver of zebrafish

Chronic waterborne zinc and cadmium exposures induced different responses towards oxidative stress in the liver of zebrafish

A protocol for identifying suitable biomarkers to assess fish health: A systematic review

Bioavailability of pollutants sets risk of exposure to biota and human population in reservoirs from Iguaçu River (Southern Brazil)

Contact Info

Product

Resources

About