Antioxidant protection of human serum albumin by chitosan

Anraku, Makoto; Kabashima, Mikie; Namura, Hitomi; Maruyama, Toru; Otagiri, Masaki; Gebicki, Janusz M.; Furutani, Nobuko; Tomida, Hisao

doi:10.1016/j.ijbiomac.2008.04.006

Cited by 67 publications

(33 citation statements)

References 51 publications

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“…Chitosan, the partly deacetylated form of chitin, is one of the materials under investigation as surface coating for orthopedic implants in order to improve osseointegration and cellular attachment [21] because of its minimal foreign body reaction, favorable wettability, a suitable degradation rate and ability to be molded in various geometries [22]. More importantly, chitosan has been demonstrated to exhibit antioxidant and free radical scavenging activities [23,24]. Despite of its excellent biological properties, little is known about the supportive function of insoluble chitosan on osteogenesis against the diabetes-mediated ROS overproduction at the bone-titanium interface.…”

Section: Introductionmentioning

confidence: 99%

Osseointegration of chitosan coated porous titanium alloy implant by reactive oxygen species-mediated activation of the PI3K/AKT pathway under diabetic conditions

Yan

et al. 2015

Biomaterials

121

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Section: Introductionmentioning

confidence: 99%

Osseointegration of chitosan coated porous titanium alloy implant by reactive oxygen species-mediated activation of the PI3K/AKT pathway under diabetic conditions

Yan

et al. 2015

Biomaterials

121

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“…Chitosan has attracted much attention as a biomedical material, as it exhibits a wide variety of biological activities, such as antitumor activities [7]- [9], immunostimulating effects [10], antiallergic effects [11], hemostatic agent [12], anticoagulant effects [13] [14] hypocholesterolemic effects [15], antiinflammatorty activities [16], free radical scavenging activities [17], antimicrobial effects [18], antibacterial effects [19] [20] wound-healing effects [21] [22], antifungal activities [23] [24] and antiviral activity [25]. However, because of its high molecular weight and water-insolubility, the applications of chitosan are severely limited.…”

Section: Introductionmentioning

confidence: 99%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

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This study was conducted to prepare chitosan nanoparticles (CNPs), to determine their properties and to evaluate the synergistic protective role of CNPs alone or in combination with quercetin (Q) against oxidative stress and hepatotoxicity in rats. Female Sprague-Dawley rats were divided into 12 groups (7 rats/group) and were maintained on their respective diet for 3 weeks as follow: control group, the group treated with CCl4 (100 mg/kg b.w twice a week); the groups received CNPs at low and high doses (140 and 280 mg/kg b.w); the group received Q (50 mg/kg b.w); the groups received CNPs at the low or high doses plus Q and the groups treated with CCl4 plus Q and/or CNPs at the two tested doses. Blood and liver samples were collected at the end of experiment period for biochemical and histological studies. The results indicated that chitosan showed deacetylation degree of 17.5% and 19.2% and the molar mass average of monomer was 168.35 g/mol and 169.1 g/mol by UV and IR methods respectively. The particle size of CNPs was around 100 nm with a rough surface. The in vivo results revealed that CCl4 induced biochemical and histological changes typical to those reported in the literature. Animals treated with CNPs at the two tested doses alone or in combination with Q were comparable to the control. CNPs alone or plus Q succeeded to induce significant improvements in the biochemical parameters and histological picture of the liver in rats treated with CCl4. This improvement was in dose-dependent manner for CNPs and was * Corresponding author. E. S. El-Denshary et al. 37more pronounced in the group treated with the high dose plus Q. It could be concluded that both CNPs and Q could induce protection against hepatotoxicity. Consequently, CNPs was a promise candidate as drug delivery in liver diseases treatments.

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“…Chitosan as an anti-oxidant: Chitosan has an in vivo stimulatory effect on both nitric oxide production and modulates peroxide production [27]. Neutrophil activation was inhibited by administration of chitosans with low molecular weight and oxidation of serum albumin commonly observed in patients undergoing haemodialysis, resulting in reduction of oxidative stress associated with uremia [28].…”

Section: Chitosanmentioning

confidence: 99%

Biomedical Biopolymers, their Origin and Evolution in Biomedical Sciences: A Systematic Review

Yadav

Yadav²,

Shah

et al. 2015

JCDR

112

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Antioxidant protection of human serum albumin by chitosan

Cited by 67 publications

References 51 publications

Osseointegration of chitosan coated porous titanium alloy implant by reactive oxygen species-mediated activation of the PI3K/AKT pathway under diabetic conditions

Osseointegration of chitosan coated porous titanium alloy implant by reactive oxygen species-mediated activation of the PI3K/AKT pathway under diabetic conditions

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

Biomedical Biopolymers, their Origin and Evolution in Biomedical Sciences: A Systematic Review

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