Antioxidant properties of water-soluble amino acid derivatives of fullerenes and their role in the inhibition of herpes virus infection

Kotelnikova, R. A.; Faingold, I. I.; Poletaeva, D. A.; Мищенко, Д. В.; Романова, В. С.; Shtol’ko, V. N.; Богданов, Г. Н.; Rybkin, A. Yu.; Frog, E. S.; Smolina, A. V.; Кущ, А А; Федорова, Н. Е.; Котельников, А. И.

doi:10.1007/s11172-011-0184-x

Cited by 33 publications

(7 citation statements)

References 6 publications

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“…According to Tilton et al (2011), virally infected cells boost the synthesis of antioxidant enzymes that can swiftly remove ROS and maintain redox equilibrium. The current investigation supported Tilton et al, (2011) findings that CMV infection raises antioxidant levels [21].…”

Section: Discussionsupporting

confidence: 91%

Evolution the Correlation Between the Severity of Cytomegalovirus Infection among Aborted Women with Vitamin D and Oxidative Stress Biomarkers

Hussein¹

2022

Proceedings of 2nd International Multi-Disciplinary Conference Theme: Integrated Sciences and Technologies, IMDC-IST 2021, 7-9

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The most common complication of early pregnancy is abortion. Embryo-fatal infections have been documented to cause less than 4% of spontaneous abortions (SAs). Viruses, notably cytomegalovirus, appear to be the most frequently involved pathogens. The study is a case-control study conducted in Bint Al-Huda Teaching Hospital in the period between October 2020 to March 2021. One hundred subjects enrolled in this study and divided into (25) aborted CMV + women, (25) aborted CMVwomen, (25) non-aborted CMV + women as patients' groups, and (25) nonaborted women with cytomegalovirus seronegative test as a control group. This study was designed to assess the correlation between the severity of CMV infection among aborted women with VD levels and oxidative stress biomarkers (Malondialdehyde, Ceruloplasmin, and transferrin). Anticytomegalovirus antibody was positively correlated with vitamin D, MDA, and ceruloplasmin and negatively correlated with transferrin as an oxidative stress biomarker.

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Section: Discussionsupporting

confidence: 91%

Evolution the Correlation Between the Severity of Cytomegalovirus Infection among Aborted Women with Vitamin D and Oxidative Stress Biomarkers

Hussein¹

2022

Proceedings of 2nd International Multi-Disciplinary Conference Theme: Integrated Sciences and Technologies, IMDC-IST 2021, 7-9

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“…Their roles in the inhibition of herpes virus infection have also been described. 39 The amino acid fullerene derivatives 148 and 149 of [60]fullerene were found to have significant antioxidant activities and were not cytotoxic (IC 50 1000 and 1200 μg mL -1 (mln. cells), for 149 and 148, respectively).…”

Section: Biological Applicationsmentioning

confidence: 99%

[60]Fullerenyl amino acids and peptides: a review of their synthesis and applications

2014

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This review reports on the latest progress in the synthesis of fullerenyl amino acids and related derivatives, and categorises the molecules into functional types for different uses: these include directly attached fullerenyl amino acids, fullerenyl N-and C-capping amino acids, and those amino acids in which the [60]fullerene group is attached to the amino acid side chain. These first and last mentioned derivatives have the potential to be incorporated into non-terminal positions of peptides. The applications of these substrates, by integration into different biological and materials chemistry programs, are also highlighted. This review reports on the latest progress in the synthesis of fullerenyl amino acids and related derivatives, and categorises the molecules into functional types for different uses: these include directly attached fullerenyl amino acids, fullerenyl N-and C-capping amino acids, and those amino acids in which the [60]fullerene group is attached to the amino acid side chain. These first and last mentioned derivatives have the potential to be incorporated into non-terminal positions of peptides. Disciplines Medicine and Health Sciences | Social and Behavioral SciencesThe applications of these substrates, by integration into different biological and materials chemistry programs, are also highlighted.

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“…These effects suggested that NM was an NO donor. The genesis and progression of various pathologies are related to disruption of equilibrium in LPO systems, i.e., antioxidant protection, which requires the appropriate adjustment using exogenous antioxidants [16,17].…”

Section: Resultsmentioning

confidence: 99%

Effect of Mexidol and Nitroxymexidol on Phosphodiesterase Activity, Some Oxidation Processes, and Hypoxia Resistance

et al. 2014

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The effect of mexidol (M) and nitroxymexidol (NM) on the activity of phosphodiesterase of cyclic guanosine monophosphate (PDEcGMP), regulation of lipid peroxidation (LPO), and antiradical and antihypoxic activity was investigated under normoxia and normobaric hypercapnic hypoxia conditions. Reversible and noncompetitive inhibition of the hydrolytic function of PDEcGMP by M and NM was revealed. The K i value for M was 1´10 -4 M; for NM, 1´10 -5 M, i.e., NM was 10 times more active than M. It was shown that the lifetime of experimental animals in a closed space increased by 36% under the action of M as compared with that of the control group while it increased by 53% for NM. The ventricular contraction time increased by 137% for NM. The atrial contraction time increased from 31 min in the control to 52 and 57 min for M and NM, respectively.Syntheses of new highly effective and non-toxic drugs capable of generating NO during biotransformation have recently been developed at the IPCP, RAS [1, 2].Mexidol (M) is widely used in medical practice as a lipid peroxidation (LPO) inhibitor [3,4].A new non-toxic mexidol derivative, nitroxymexidol (NM), was synthesized at the IPCP, RAS [5].The goal of the present work was to study the roles of M and NM in the regulation of LPO, antiradical protection, modulation of cyclic guanosine monophosphate (cGMP) phosphodiesterase (PDE) activity, and antihypoxic activity with normoxia and hypercapnic normobaric hypoxia. EXPERIMENTAL PARTWe used cGMP nucleotidase (as cobra venom), histidine, and Tris-HCl (Sigma) without additional purification. Trichloroacetic acid and ammonium molybdate (Reakhim, Russia) were purified before use. Mexidol (M) was synthesized as before [6]. Nitroxymexidol (NM) was synthesized by the literature method [5] with its nitro group bonded to succinic acid. It was 98% pure according to GC.PDE of cGMP (PDEcGMP) was isolated from the brain cortex of male Wistar rats [7]. Brain tissue was homogenized in a Potter homogenizer in ten times the weight of cold Tris-HCl buffer (0.2 M) at pH 7.5. The homogenate was centrifuged for 1 h at 40,000 g in a K-32M centrifuge. The supernatant containing the enzyme was frozen in liquid nitrogen. 4170091-150X/14/4807-0417

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Antioxidant properties of water-soluble amino acid derivatives of fullerenes and their role in the inhibition of herpes virus infection

Cited by 33 publications

References 6 publications

Evolution the Correlation Between the Severity of Cytomegalovirus Infection among Aborted Women with Vitamin D and Oxidative Stress Biomarkers

Evolution the Correlation Between the Severity of Cytomegalovirus Infection among Aborted Women with Vitamin D and Oxidative Stress Biomarkers

[60]Fullerenyl amino acids and peptides: a review of their synthesis and applications

Effect of Mexidol and Nitroxymexidol on Phosphodiesterase Activity, Some Oxidation Processes, and Hypoxia Resistance

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