Antioxidant properties of some novel derivatives thiazolo[4,5-b] pyridine

Abstract

The synthesis and determination of the antioxidant activity of some novel (5,7-dimethyl-2-oxo-thiazolo[4,5-b]pyridine-3-yl)-acetic acid hydrazide derivatives are described in this article. The transformation of the base heterocycle was carried out via the reactions of acylation, [2+3]cyclocondensation, Knoevenagel condencation and alkylation for the purpose to obtain substances with a satisfactory pharmacological profile. Antioxidant activity of the synthesized compounds was evaluated in vitro by means of the scavenging metod effect on 2,2 diphenyl-1-picrylhydrazyl (DPPH) radicals.

Synthesis antimicrobial and antitumor activities of 2-[5-(2-R-benzyl)thiazol-2-ylimino]thiazolidin-4-ones

“…Previously we have successfully demonstrated the use of diazonium salts in the synthesis of biologically active heterocycles such as furane [13,14], thiazole [15][16][17] and triazole [18,19]. Various combinatorial libraries of condensed compounds were also prepared [13,14,18,[21][22][23][24][25][26][27][28][29][30][31][32]. Thus, the research to explore different chemical modifications avenues of diazonium salts to obtain novel active compounds should be continued.…”

Anti-inflammatory properties of some novel thiazolo[4,5-b]pyridin-2-ones

“…Thiazolidone derivatives anelated with the pyridine cycle, in particular thiazolopyridine, are of particular interest to researchers because these compounds exhibit different types of biological activity. Among them were identified substances with antioxidant (Chaban et al 2013(Chaban et al , 2019aKlenina et al 2013Klenina et al , 2017, fungicidal (Marzoog and Al-Thebeiti 2000), anti-inflammatory (Chaban et al 2016(Chaban et al , 2017b(Chaban et al , 2018b, anti-mitotic (Victor et al 2017), tuberculostatic (Chaban et al 2014), herbicidal (Hegde and Mahoney 1993) and antitumor (Chaban et al 2012a) activities, agonists of H3-histamine receptors (Walczyn´ski et al 2005), antagonists of metabotropic glutamate receptors 5 (mGluR5) (Lin et al 2009), substances with high inhibitory activity against epidermal growth factor receptors (Komoriya et al 2006) and several other enzymes (Singh et al 1995). Given the above synthesis of new thiazolopyridines, as well as the pharmacological screening of the anti-inflammatory activity of the newly synthesized compounds is an interesting and relevant direction.…”

Synthesis, molecular docking and anti-inflammatory activity 2,4-dimethyl-N-(2-aryl)-3-furamides

“…8 In a previous work 9 we have described the synthesis and anti-inflammatory activities of some 2,5-dimethyl-3-furan-3-carboxamides and 5-aryl-2-methyl-3-furan-3-carboxamides. In this article which is the part of our project on of biologically active heterocycles [10][11][12][13][14][15][16][17][18][19][20][21][22][23] we describe synthesis, molecular docking and anti-inflammatory activities of 2,4-dimethyl-N-(2-aryl)-3-furamides.…”