Synthesis antimicrobial and antitumor activities of 2-[5-(2-R-benzyl)thiazol-2-ylimino]thiazolidin-4-ones
Abstract:By the reaction of N-(5-R-benzyl-thiazol-2-yl)-2-chloroacetamides with potassium thiocyanate were synthesized 2-[5-(2-R-benzyl)thiazol-2-ylimino]thiazolidin-4-ones. The structures of target compounds 9a-e were confirmed by using NMR spectroscopy and elemental analysis. The antimicrobial and anticancer activity of synthesized compounds was evaluated. The compounds with high antimicrobial activity against Staphylococcus aureus ATCC 43300 were identified.
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