Antioxidant properties of scopoletin isolated from <i>Sinomonium acutum</i>

Shaw, Chin-Ying; Chen, Chen‐Hui; Hsu, Chen‐Chin; Chen, Chien-Chih; Tsai, Ying-Chieh

doi:10.1002/ptr.1170

Cited by 132 publications

(93 citation statements)

References 13 publications

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“…Scopoletin, a coumaric derivative was also detected in these fractions (Radwan and Shams, 2007). Scopoletin has been also found to possess antioxidant activity (Shaw et al, 2003).…”

Section: Halocnemum Strobilaceummentioning

confidence: 94%

Phytochemical composition of some common coastal halophytes of the United Arab Emirates

Cybulska

Brudecki

Alassali

et al. 2014

Emir. J. Food Agric

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Halophyte species of United Arab Emirates are a source of unique active phytochemicals, potentially due to the extreme environmental conditions under which the plants grow in the UAE. These phytochemicals make the native halophytes possibly interesting crops for biorefining, where biofuel production is combined with the production of value added chemicals, improving the economic feasibility of both process. Phytochemicals found in these species are widely recognized and researched as potential pharmaceutical and nutraceutical products. We reviewed the literature for secondary metabolites from species from the following halophyte families: Aizoaceae, Amaranthaceae (incl. Chenopodiaceae), Avicenniaceae, Zygophyllaceae. The review revealed that plant species belonging to these families contain valuable phytochemicals, such as fatty acids, terpenoids, flavonoids, alkaloids, steroids, tannins, saponins, quinones and coumarins, many of which have been reported to have therapeutic effects in humans.

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“…Scopoletin, a coumaric derivative was also detected in these fractions (Radwan and Shams, 2007). Scopoletin has been also found to possess antioxidant activity (Shaw et al, 2003).…”

Section: Halocnemum Strobilaceummentioning

confidence: 94%

Phytochemical composition of some common coastal halophytes of the United Arab Emirates

Cybulska

Brudecki

Alassali

et al. 2014

Emir. J. Food Agric

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“…Three groups of rats were orally administered with scopoletin suspension, Sco-PM or Sco-Ms at an equivalent dose of 100 mg/kg scopoletin. The blood samples (approximately 0.3 mL) were collected via the orbital venous plexus at predetermined time intervals (2,5,10,15,20,30,45,60,90, and 120 min). All blood samples were immediately centrifuged at 3000×g for 5 min, and then the plasma supernatant was collected.…”

Section: Pharmacokinetic and Biodistribution Studymentioning

confidence: 99%

“…Scopoletin has been reported to show extensive pharmacologic actions, including anti-oxidative [2,3] , anti-thyroid [3] , anti-hyperglycemic [3] , anti-nociceptive [4] and anti-arthritic effects [5,6] . In addition, scopoletin is a partially selective monoamine oxidase B inhibitor that increases the brain dopamine level [7] .…”

Section: Introductionmentioning

confidence: 99%

Soluplus micelles for improving the oral bioavailability of scopoletin and their hypouricemic effect in vivo

Zeng

Liu

et al. 2017

Acta Pharmacol Sin

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Scopoletin is an active coumarin possessing a variety of pharmacological activities, including anti-hyperuricemic effect, but with poor solubility. To improve its oral bioavailability, we attempted to encapsulate scopoletin into Soluplus micelles (Soluplus-based scopoletin micelles, Sco-Ms) and evaluated the hypouricemic action of Sco-Ms. Sco-Ms were prepared using a thin-film hydration method. Sco-Ms displayed near spherical shapes with an average size of 59.4±2.4 nm (PDI=0.08±0.02). The encapsulation efficiency of scopoletin was 87.3%±1.5% with a loading capacity of 5.5%±0.1%. Sco-Ms were further characterized using transmission electron microscopy, powder X-ray diffraction, Fourier transform infrared techniques and scanning electron microscopy. After oral administration in rats, Sco-Ms exhibited significantly improved absorption in each intestinal segment compared to free scopoletin, with the duodenum and jejunum being the main absorption regions. In rats administered Sco-Ms (at an equivalent dose of free scopoletin of 100 mg/kg, po), the AUC 0-∞ and C max of Sco-Ms were 4.38-and 8.43-fold, respectively, as large as those obtained following administration of free scopoletin. After oral administration in rats, Sco-Ms did not alter the tissue distributions of scopoletin, but significantly increased the scopoletin levels in the liver. In potassium oxonate-induced hyperuricemic mice, oral administration of Sco-Ms (at an equivalent dose of free scopoletin of 300 mg/kg) reduced the serum uric acid concentration to the normal level. The results suggest that Soluplus-based micelle system greatly improves the bioavailability of poorly water-soluble drugs, such as scopoletin, and represents a promising strategy for their oral delivery.

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“…O chá das raízes também é utilizado para dores de estômago, dores de cabeça, dores musculares, disfunções hepáticas e para estimular o apetite (Silva, 1998;Vieira & Martins, 2000). O chá das folhas é usado como depurativo do sangue, nas afecções renais e hepáticas (Salles et al, 1997).…”

Section: Introductionunclassified

Estudo farmacognóstico de folhas e raízes da Spiranthera odoratissima A. St.-Hil. (Rutaceae)

Matos

Fiuza

Tresvenzol

et al. 2014

Rev. bras. plantas med.

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RESUMO:A Spiranthera odoratissima A. St.-Hil. (manacá) é um arbusto cujas raízes são utilizadas popularmente contra dores musculares, de estômago e de cabeça, disfunções hepáticas, reumatismo, e como estimulante do apetite. As folhas são empregadas como depurativo do sangue, nas afecções renais e hepáticas. O objetivo deste trabalho foi realizar o estudo morfo-anatômico de S. odoratissima, bem como a triagem fitoquímica, a determinação dos teores de água, cinzas totais e insolúveis em ácido. O material vegetal foi coletado em Leopoldo de Bulhões/ Goiás e os estudos morfo-anatômicos e a triagem fitoquímica foram realizados utilizando as técnicas convencionais. Verificou-se que a folha é hipoestomática, com estômatos anomocíticos e a epiderme apresenta papilas na face abaxial. O mesofilo é dorsiventral e a nervura principal possui drusas de oxalato de cálcio e cavidades secretoras. O pecíolo apresenta sistema vascular em forma circular. Na raiz, em crescimento primário, observou-se cilindro vascular com organização diarca. Na prospecção fitoquímica detectaram-se fenóis, taninos, cumarinas, flavonoides, triterpernos/esteróis, antraquinonas e antocianinas nas folhas e alcaloides, cumarinas, amido e saponinas nas raízes. Esses resultados são parâmetros importantes para o controle de qualidade dessa matéria-prima vegetal.Palavras chaves: Cerrado, controle de qualidade, plantas medicinais, Rutaceae.ABSTRACT: Pharmacognostic study of the leaves and roots of Spiranthera odoratissima A. St.-Hil. (Rutaceae). Spiranthera odoratissima A. St.-Hil. (manacá) is a shrub whose roots are popularly used against stomach pains, headache, muscle pain, liver disorders, rheumatism and as an appetite stimulant. The leaves are used as a blood depurative and for liver and kidney disease. The purpose of this work was to perform the morphological and anatomical study, the phytochemical screening and determine the water content and the levels of total and acid of S. odoratissima. The plant material was collected in Leopoldo de Bulhões/ Goiás and the morpho-anatomical studies and the phytochemical screening were performed using conventional techniques. It was verified that the leaf is hypostomatic, with anomocytic stomata and the epidermis has papillae on the abaxial surface. The mesophyll is dorsiventral and the midrib presents druses of calcium oxalate and secretory cavities. The petiole has a circular vascular system. The root in primary growth presents vascular cylinder with diarchic organization. Phenols, tannins, coumarins, flavonoids, triterpenes/sterols, anthraquinones and anthocyanins were detected in the phytochemical screening of the leaves, and alkaloids, coumarins, saponins and starch were detected in the roots. These results are important parameters for the quality control of the vegetal raw material.Key words: Savannah, quality control, medicinal plants, Rutaceae. INTRODUÇÃOA Spiranthera odoratissima A. St.-Hil. (Rutaceae) é uma planta do Cerrado, popularmente conhecida como Manacá e pertence à família Rutaceae. É um arbusto com...

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Antioxidant properties of scopoletin isolated from Sinomonium acutum

Cited by 132 publications

References 13 publications

Phytochemical composition of some common coastal halophytes of the United Arab Emirates

Phytochemical composition of some common coastal halophytes of the United Arab Emirates

Soluplus micelles for improving the oral bioavailability of scopoletin and their hypouricemic effect in vivo

Estudo farmacognóstico de folhas e raízes da Spiranthera odoratissima A. St.-Hil. (Rutaceae)

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