Antioxidant properties of<i>Taraxacum officinale</i>fruit extract are involved in the protective effect against cellular death induced by sodium nitroprusside in brain of rats

Colle, Dirleise; Arantes, Letícia Priscilla; Rauber, Ricardo Hummes; Mattos, Sérgio Edgar Campos de; Rocha, João Batista Teixeira da; Nogueira, Cristina W.; Soares, Félix Alexandre Antunes

doi:10.3109/13880209.2011.641981

Cited by 25 publications

(14 citation statements)

References 42 publications

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“…1). The antiradical activity of various dandelion parts was also observed by others, who studied leaf [3,18,19,20], root [17,21], flower [17,22], stalk [17,20,23], as well as fruit extracts [24].…”

Section: Discussionsupporting

confidence: 61%

The antioxidant activity of ethanolic and aqueous extracts of dandelion (Taraxacum officinale L.)

Nowak

Duchnik

Zielonka-Brzezicka

et al. 2019

Pomeranian Journal of Life Sciences

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Introduction: Dandelion (Taraxacum officinale L.) has been commonly used in traditional and contemporary medicine due to its diuretic and hepatoprotective properties. It contains polyphenols, vitamins and terpenes – i.e. compounds with antioxidant potential. Natural antioxidants protect organisms against oxidative stress, an important factor in the ageing process and in the pathogenesis of neoplastic, cardiovascular, neurodegenerative and some other diseases.Materials and methods: Raw dandelion plant material consisted of fresh and dried leaves, flowers and roots, harvested from a natural site. The extracts for analysis were prepared using an ultrasonic bath (extraction time 15, 30 and 60 min) in water, and 40% (v/v), 70% (v/v) and 96% (v/v) ethanol mixtures used as solvents. Antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) methods.Results: The antioxidant activity of dandelion depended on the type of raw material used, as well as the type of solvent and extraction time. The highest DPPH activity was found for dried flower extracts prepared in 70% ethanol for 30 min. With FRAP method, the highest reduction capacity was observed for dried leaf extracts in 40% ethanol for 30 min.Conclusions: The antioxidant potential of ethanolic and aqueous dandelion extracts was observed. This finding suggests the usefulness of this plant as a source of antioxidants to be used in pharmaceutical and cosmetic industries.

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Section: Discussionsupporting

confidence: 61%

The antioxidant activity of ethanolic and aqueous extracts of dandelion (Taraxacum officinale L.)

Nowak

Duchnik

Zielonka-Brzezicka

et al. 2019

Pomeranian Journal of Life Sciences

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“…T . officinale , as a radical scavenger, could improve levels of serum ALT and AST induced by oxidative stress [ 45 ]. The present study shows that the administration of DMG-Na effectively attenuated the progression of LPS-induced oxidative stress in mice.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Free Radical Scavenging Activity of Dimethylglycine Sodium Salt and Its Role in Providing Protection against Lipopolysaccharide-Induced Oxidative Stress in Mice

Bai

Zhang

et al. 2016

PLoS ONE

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In the present study, the free radical scavenging activities (against 1,1-diphenyl-2-pierylhydrazy (DPPH), 2,2'-Azinobis-(3-ethylbenzthiazoline-6- sulphonate) (ABTS+), Hydrogen peroxide (H2O2)) of dimethylglycine sodium salt (DMG-Na) were measured and compared with those of Trolox (6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid), a commonly used antioxidant. The radical scavenging activities of DMG-Na were found to be the highest at 40 mg/ml. In Experiment 2, gastric intubation in mice with 12 mg DMG-Na/0.3 ml sterile saline solution significantly increased (P < 0.05) the body weight (BW) (28 d), organ proportion (liver and spleen), and antioxidant capacity in serum and the liver (Superoxide dismutase (SOD), Hydrogen peroxidase (CAT), Glutathione peroxidase (GPx), and Total antioxidant capacity (T-AOC)), and significantly decreased (P < 0.05) the activities of serum Glutamic-pyruvic transaminase (ALT) and Glutamic oxalacetic transaminase (AST) and Methane Dicarboxylic Aldehyde (MDA) contents in the serum and liver. Specifically, the effect of 12 mg DMG-Na/0.3 ml sterile saline solution, which showed the highest antioxidant capacity, was further studied using a mice model. In Experiment 3, the mice CL (CON+ lipopolysaccharide (LPS)) group showed a significant decrease (P < 0.05) in the serum ALT and AST content; hepatic mitochondrial antioxidant capacity (Manganese Superoxide dismutase (MnSOD), Glutathione reductase (GR), GPx, Glutathione (GSH)); MDA and Protein carbonyl (PC) content; Reactive oxygen species (ROS) level, Mitochondrial membrane potential (MMP) level, and expression of liver antioxidant genes (Nuclear factor erythroid 2-related factor 2 (Nrf2), Heme oxygenase 1 (HO-1), Manganese superoxide dismutase (MnSOD), Glutathione peroxidase 1 (Gpx1), Sirtuin 1 (Sirt1)) relative to the mice CS (CON+ sterile saline) group. The DL (DMG+LPS) group showed a significant decrease (P < 0.05) in serum ALT and AST content, ROS level, and expression of liver antioxidant gene MnSOD, Gpx1, Sirt1 and a significant increase (P < 0.05) in the hepatic mitochondrial antioxidant capacity (MnSOD, GSH, GPx, GR) and MMP level relative to the CL group. These results indicate that DMG-Na could protect against the LPS-induced oxidative stress by enhancing the free radical scavenging capacity, and increasing the activity of antioxidant defense system.

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“…Reactive oxygen species (ROS), including singlet oxygen, superoxide anions, hydroxyl radicals, and hydrogen peroxide, are a general output of aerobic metabolism and can also originate in response to insults such as heat, cytokines, hydrogen peroxide, and radiation. 1 , 2 Under normal conditions, antioxidants in the body control ROS content; however, inadequate antioxidant content or ROS overproduction can result in pathophysiological conditions. The aging process is closely related to increased ROS levels.…”

Section: Introductionmentioning

confidence: 99%

Malvidin Protects WI-38 Human Fibroblast Cells Against Stress-induced Premature Senescence

Seo

Choi

et al. 2016

J Cancer Prev

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Background:Malvidin is one of the most abundant components in red wines and black rice. The effects of malvidin on aging and lifespan under oxidative stress have not been fully understood. This study focused on the anti-aging effect of malvidin on stress-induced premature senescence (SIPS) in WI-38 human lung-derived diploid fibroblasts.Methods:In order to determine the viability of WI-38 cells, MTT assay was conducted, and malondialdehyde level was determined using thiobarbituric acid-reactive substance assay. Protein expression of inflammation-related factors was also evaluated by Western blot analysis.Results:Acute and chronic oxidative stress via hydrogen peroxide (H2O2) treatment led to SIPS in WI-38 cells, which showed decreased cell viability, increased lipid peroxidation, and a shortened lifespan in comparison with non-H2O2-treated WI-38 cells. However, malvidin treatment significantly attenuated H2O2-induced oxidative stress by inhibiting lipid peroxidation and increasing cell viability. Furthermore, the lifespan of WI-38 cells was prolonged by malvidin treatment. In addition, malvidin downregulated the expression of oxidative stress-related proteins, including NF-κB, COX-2, and inducible nitric oxide synthase. Furthermore, protein expression levels of p53, p21, and Bax were also regulated by malvidin treatment in WI-38 cells undergoing SIPS.Conclusions:Malvidin may potentially inhibit the aging process by controlling oxidative stress.

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Antioxidant properties ofTaraxacum officinalefruit extract are involved in the protective effect against cellular death induced by sodium nitroprusside in brain of rats

Cited by 25 publications

References 42 publications

The antioxidant activity of ethanolic and aqueous extracts of dandelion (Taraxacum officinale L.)

The antioxidant activity of ethanolic and aqueous extracts of dandelion (Taraxacum officinale L.)

Assessment of Free Radical Scavenging Activity of Dimethylglycine Sodium Salt and Its Role in Providing Protection against Lipopolysaccharide-Induced Oxidative Stress in Mice

Malvidin Protects WI-38 Human Fibroblast Cells Against Stress-induced Premature Senescence

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