Antioxidant properties of humic acids from brown coal

Khil’ko, S. L.; Efimova, I. V.; Smirnova, O.V.

doi:10.3103/s036152191106005x

Cited by 40 publications

(32 citation statements)

References 10 publications

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“…Some of the clinical studies revealed a positive response to treatment only after humic acid dosage, treatment for viral respiratory illness is clear evidence [43] Fulvic acid activate the immune system to kill bacteria, meantime it decrease proinflammatory markers. Immune modulating property of fulvic acid influence the redox state, and affect gut health [44]. Antioxidant property exhibited by humic substances and its fractions were evidenced in research work carried by Avvakumova et al [45].…”

Section: Antioxidant and Immune Boosting Property Of Humic Substancesmentioning

confidence: 95%

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Jacob

Chandramohanakumar

2019

Int J App Pharm

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Efficiency of therapeutic compounds could be enhanced by encapsulation and covalent attachments to a biomaterial carrier. Complex formation with humic substances is valuable techniques to improve bioactivity of natural products. Fractal structures of humic substances also have adjacent carboxyl and hydroxyl groups. Along with molecular bonding property, reduction-oxidation and association-dissociation capacities of humic substances are considered this as a biomaterial for transform, other molecules, and substances. Immune system responses of humic acid stimulates in the human body. However, pharmaceutical importance of humic substances, demands on evidenced efficacy and a clearly defined chemical composition of the preparations used. Toxicological safety standards also have to be evaluated. This review summarises the application of humic substances as pharmaceuticaly important biomaterial. Research on this zone opened up an application for humic substances in pharmacogonasy.

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Section: Antioxidant and Immune Boosting Property Of Humic Substancesmentioning

confidence: 95%

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Jacob

Chandramohanakumar

2019

Int J App Pharm

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“…The criterion for assessing the effect of HA on D. magna was the survival index of juvenile form of daphnia in two types of water solutions with different concentrations of HA: 1) In the model solution prepared on the basis of deionized water in the presence of mineral salts [17,19] with the addition of HA. The model solution of mineral salts (MS) without the addition of HA served as control.…”

Section: Effect Of Humic Substances On D Magna Survivalmentioning

confidence: 99%

“…At the same time, there are quite numerous data in the literature on the negative effect of HS on the state of living organisms. For example, HS can also inhibit plant growth [12], cause expression of heat shock proteins [13,14], modulate biotransformation enzymes because of oxidative stress [15][16][17], inhibit photosynthetic oxygen release in plants [18][19][20][21], alter ionic homeostasis in freshwater animals [22][23][24][25], as well as have hormonelike effects on water crustaceans [26,27], amphibians [28], fish [29,30] and other animals [31,32].…”

Section: Introductionmentioning

confidence: 99%

Correlation Biological Activity and Physicochemical Properties of Humic Acids in Aqueous Solutions

Доленко

Kravchenko

Zlatskiy

2020

Pol. J. Environ. Stud.

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Objective. The biological activity of humic acids (HA), considering them as open non-equilibrium systems, in which properties are determined by the state or level of organization of the system.Methods. The dependence of physicochemical properties of HA on their concentration (optical and sorption properties, ζ-potential and electrical conductivity, average size of optical homogeneities) were analyzed by several methods: optical microscopy; low-angle laser light scattering (LALLS) method on a Zetasizer Nano ZS analyzer; absorption on a Shimadzu UV-3600 spectrophotometer; chemical analysis on an ICP-QMS Agilent 7500CE spectrometer. Biological activity of HA was studied on the crustacean Daphnia magna and the monocotyledonous plants Allium cepa L.Results. It was established that the nature of the HA effect on biological objects is non-linear and has an extremum at 1 mg•L -1 . It was shown that the mineralization of solutions affects the biological activity of HA. So in the presence of the addition of mineral salts, for D. magna the effect of HA is insensible, while for A. cepa L. it changes its direction. In the absence of mineral salts at HA concentrations < 5-10 mg•L -1 , a sharp drop in the survival of D. magna and suppression of root growth of A. cepa L. was observed, and in saline solution -stimulation of root growth. It has been established that the concentration range of 5-10 mg•L -1 was also critical for concentration changes in a number of physicochemical parameters of aqueous solutions of HA, which makes it possible to consider it a phase transition characterized by new properties.Findings. It was shown that changes in various properties of aqueous solutions of HA, including biological activity, were characterized by non-linear concentration dependencies with the presence of intermittent changes indicating qualitative rearrangements in the system.

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“…Khil'ko et al [10] found that humic acids from brown coal exhibited pronounced antioxidant proper ties. There is an interrelation between the antioxidant activity and the anticorrosive properties [11].…”

Section: Introductionmentioning

confidence: 99%

Acylation of humic acids

et al. 2015

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A method for the chemical modification of humic acids with benzoyl chloride under the condi tions of phase transfer catalysis was developed. It was demonstrated by potentiometric titration that the reac tion of humic acids with benzoyl chloride can occur at both hydroxyl (-OH) and carboxyl (-COOH) groups. The antioxidant activity of the initial humic acids and their chemical modification products in radical chain oxidation processes in an organic medium was determined by a gas volumetric method. A decrease in the antioxidant activity of the acylated humic acids in comparison with that of the native forms was found; this can be related to a decrease in the amount of active functional groups (-OH, -NH, and -SH) due to binding with benzoyl chloride.

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Antioxidant properties of humic acids from brown coal

Cited by 40 publications

References 10 publications

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Correlation Biological Activity and Physicochemical Properties of Humic Acids in Aqueous Solutions

Acylation of humic acids

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