Antioxidant properties of Etlingera pubescens, an edible ginger plant endemic to Borneo

Bactericidal and cytotoxic activity of a diarylheptanoid (etlingerin) isolated from a ginger ( Etlingera pubescens ) endemic to Borneo

“…Based on results displayed in Table 3, etlingerin exhibited significantly higher IC 50 values (about 5-to 12-fold) than curcumin, on all three cell lines, thus implying that the former is less cytotoxic than the latter. The results are in accordance with our previous work, whereby etlingerin showed approximately 4-to 10-fold higher IC 50 values than curcumin, against HaCaT (human keratinocyte), CCD-841 (human colon normal), HT-29 (human colon cancer) and SW-480 (human colon cancer) cell lines (Daniel-Jambun et al 2018).…”

“…The results are in accordance with our previous work, whereby etlingerin showed approximately 4‐ to 10‐fold higher IC 50 values than curcumin, against HaCaT (human keratinocyte), CCD‐841 (human colon normal), HT‐29 (human colon cancer) and SW‐480 (human colon cancer) cell lines (Daniel‐Jambun et al . ).…”

“…In our recent work, we showed that etlingerin possesses excellent protective effects on mammalian cells that were challenged with hydrogen peroxide (Daniel‐Jambun et al . ). In addition to exhibiting antioxidant activities, etlingerin was also found to have bacterial inhibition property, as demonstrated in this study.…”

“…1,7‐bis(3,4‐dihydroxyphenyl)heptan‐3‐yl acetate (etlingerin) was isolated through bioactivity‐guided, and identified, based on our previous work (Daniel‐Jambun et al . ). The spectroscopic data for etlingerin in this study is identical to the data shown in a study conducted by Daniel‐Jambun et al .…”

“…The spectroscopic data for etlingerin in this study is identical to the data shown in a study conducted by Daniel‐Jambun et al . (): oil‐like; 1 H NMR (CD 3 OD, 700 MHz) δ 6·67 (d, J = 8·0 Hz, 1H, H‐5a), 6·67 (d, J = 8·0 Hz, 1H, H‐5b), 6·61 (s, broad, 2H, H‐2a, H‐2b), 6·48 (d, broad, J = 8·0 Hz, 2H, H‐6a, H‐6b), 4·86 (quintet, J = 6·3 Hz, 1H, H‐3), 2·50 (m, 2H, H‐1), 2·44 (m, 2H, H‐7), 2·01 (s, 3H, NCOOC H 3 ), 1·78 (m, 2H, H‐2), 1·59 (m, 2H, H‐4), 1·53 (m, 2H, H‐6), 1·31 (m, 2H, H‐5); 13 C NMR (176 MHz, MeOD) δ 171·56 (N C OOCH 3 ), 144·75 (C, C‐3a), 144·63 (C, C‐3b), 142·93 (C, C‐4a), 142·72 (C, C‐4b), 133·97 (C, C‐1a), 133·15 (C, C‐1b), 119·27 (CH, C‐6a), 119·19 (CH, C‐6b), 115·13 (CH, C‐2a), 115·06 (CH, C‐2b), 114·92 (CH, C‐5a), 114·81 (CH, C‐5b), 73·90 (CH, C‐3), 35·78 (CH 2 , C‐2), 34·60 (CH 2 , C‐7), 33·56 (CH 2 , C‐4), 31·10 (CH 2 , C‐6), 30·73 (CH 2 , C‐1), 24·29 (CH 2 , C‐5), 19·72 (CH 3 , NCOO C H 3 ); LCESIMS m / z 374·1769 (calculated MW for C 21 H 26 O 6 , 374·1730).…”