Antioxidant properties of different molecular weight polysaccharides from Athyrium multidentatum (Doll.) Ching

Sheng, Jian‐Zhong; Sun, Yan

doi:10.1016/j.carbpol.2014.03.011

Cited by 101 publications

(60 citation statements)

References 23 publications

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“…Figure 5 shows Triple helix stereo-configuration, higher degrees of branching, moderate molecular weight, and water solubility are other factors that could contribute antioxidant properties (Kungel et al, 2018;Smirnov et al, 2017;Wang et al, 2013;Wang, Hu, Nie, Yu, & Xie, 2015;Xiao & Jiang, 2015;Zhao et al, 2018). The molecular weight of a polysaccharide has a pronounced effect on the biological activity, generally, low molecular weight polysaccharides exhibit higher antioxidant activity than high molecular weight polysaccharides (Sheng & Sun, 2014). This may be due to the deterioration of high molecular weight polysaccharides and poor penetration capabilities of cell membranes (Wu, Zheng, Ning, & Yang, 2007).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Structural characterization and determination of biological activities for different polysaccharides extracted from tree mushroom species

et al. 2019

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Chemical composition and structural characterization of polysaccharides of Fomes fomentarius (FF), Fuscoporia torulosa, Ganoderma adspersum, Ganoderma applanatum (GAP), Ganoderma lucidum, Phellinus igniarius, Pleurotus ostreatus (PO), and Porodaedalea pini (PP) tree mushrooms with antioxidant and anticholinesterase activities were determined in this research. Total carbohydrate contents of the polysaccharides were ranged between 65.06 ± 6.76 and 88.27 ± 5.15 µg/mg and total protein contents were ranged between 3.18 ± 0.72 and 6.56 ± 1.25 µg/mg. Galactose, glucose, and mannose were identified as major monosaccharides in all polysaccharides using gas chromatography‐mass spectrometry. FT‐IR analysis showed the characteristic peaks of the polysaccharides and high performance liquid chromatography‐diode array detection was used to determine the molecular weight of the polysaccharides. In β‐carotene–linoleic acid assay FF (IC50: 2.55 ± 0.40 µg/ml) displayed the highest antioxidant activity, whereas GAP indicated the highest antioxidant activity in cupric reducing antioxidant capacity (A0.50:59.90 ± 0.53 μg/ml), ABTS•+ (IC50: 16.62 ± 0.31 μg/ml), and DPPH• (IC50: 45.58 ± 0.21 μg/ml) assays. In cholinesterase inhibitory activity test, PO (56.31±0.0.74%) showed significant inhibitory activity against butyrylcholinesterase enzyme. Practical applications Polysaccharides from mushrooms are the major class of bioactive compounds with various biological activities. Several studies were performed on the biological activity of the polysaccharide extracts from different mushrooms. However, to our knowledge, this is the first report on the chemical composition, structural characterization, antioxidant, and anticholinesterase activities of extracted polysaccharides from studied mushrooms in detail. This investigation shows that polysaccharide extracts obtained from tree mushrooms show a significant bioactivity and these polysaccharides might be used as bioactive natural sources in the pharmaceutical, food, and cosmetic industries.

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Section: Antioxidant Activitymentioning

confidence: 99%

Structural characterization and determination of biological activities for different polysaccharides extracted from tree mushroom species

et al. 2019

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“…Athyrium multidentatum (Doll) Ching is one of the most common ferns in the north-east of China and exhibits several pharmacologically relevant effects such as tranquilization, blood pressure reduction, and diuresis. Polysaccharide-rich fractions from this fern were found to exhibit strong antioxidant activity (Sheng et al 2011;Liu et al 2011aLiu et al , b, c, 2013aSheng 2014;Sheng and Sun 2014), and a polysaccharide extract from A. multidentatum (Doll.) Ching showed remarkable anti-aging activity (Liu et al 2015).…”

Section: Athyriaceaementioning

confidence: 99%

Phytochemicals from fern species: potential for medicine applications

et al. 2017

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Ferns are an important phytogenetic bridge between lower and higher plants. Historically they have been used in many ways by humans, including as ornamental plants, domestic utensils, foods, and in handicrafts. In addition, they have found uses as medicinal herbs. Ferns produce a wide array of secondary metabolites endowed with different bioactivities that could potentially be useful in the treatment of many diseases. However, there is currently relatively little information in the literature on the phytochemicals present in ferns and their pharmacological applications, and the most recent review of the literature on the occurrence, chemotaxonomy and physiological activity of fern secondary metabolites was published over 20 years ago, by Soeder (Bot Rev 51:442–536, 1985). Here, we provide an updated review of this field, covering recent findings concerning the bioactive phytochemicals and pharmacology of fern species

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“…AMC is a unique and nutritious potherb in Changbai Mountain area and widely used as an effective folk medicine for conditions such as high blood pressure, anxiety and arthritis 12, 13 . Our previous studies demonstrated that AMC exhibited excellent antioxidant activity, anti-proliferative, and pro-apoptotic properties on HepG2 cells.…”

Section: Disscussionmentioning

confidence: 99%

“…Sheng et al . assessed antioxidant activity of degraded polysaccharides from AMC and found all four low molecular polysaccharides exhibited antioxidant activity in vitro systems 13 . Our previous research demonstrated that AMC was a quality nutrition source for proteins, carbohydrates, fat, and minerals.…”

Section: Introductionmentioning

confidence: 99%

Athyrium multidentatum (Doll.) Ching extract induce apoptosis via mitochondrial dysfunction and oxidative stress in HepG2 cells

Liu

Fan

et al. 2017

Sci Rep

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Athyrium multidentatum (Doll.) Ching (AMC), a unique and nutritious potherb widely distributed in china, has been extensively used in traditional Chinese medicine. Previous studies indicated that AMC extract exhibited antioxidant and antitumor properties. However, the chemical composition of AMC and molecular mechanism of AMC toxicity to HepG2 cells have not yet been elucidated. Hence, this study aimed to investigate the chemical compositions and the underlying mechanisms of the antiproliferative and apoptotic effects of AMC on HepG2. HPLC-MS analysis showed that AMC contain five compounds with chlorogenic acid accounting for 43 percent. Also, AMC strongly inhibited the cell growth and induced apoptosis and cell cycle arrest in HepG2 cells by significantly upregulating the protein expressions of Fas, Fas-L, Bax/Bcl-2, cyto-c, cleaved caspase-3, and PARP in a dose-dependent manner, which indicates AMC induces apoptosis in HepG2 cells through both intrinsic and extrinsic pathways. Moreover, AMC provoked the production of ROS, H2O2, and NO, modulating the PI3K/Akt, MAPK, NFκB and Nrf2 pathways and their downstream transcriptional cascades, ultimately evoked oxidative stress and apoptosis in HpeG2 cells. Further in vivo experiments demonstrated that AMC significantly suppressed the tumor growth, suggesting that AMC may be a novel promising agent for hepatocellular carcinoma treatment.

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Antioxidant properties of different molecular weight polysaccharides from Athyrium multidentatum (Doll.) Ching

Cited by 101 publications

References 23 publications

Structural characterization and determination of biological activities for different polysaccharides extracted from tree mushroom species

Structural characterization and determination of biological activities for different polysaccharides extracted from tree mushroom species

Phytochemicals from fern species: potential for medicine applications

Athyrium multidentatum (Doll.) Ching extract induce apoptosis via mitochondrial dysfunction and oxidative stress in HepG2 cells

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