Antioxidant Properties of Curcumin and Its Impact on Arteriovenous Fistula Maturation in End-Stage Kidney Disease Patient with Diabetes Mellitus Type 2

Pratama, Dedy; Yuwono, Hendro Sudjono; Supriyadi, Rudi; Herman, Herry; Damara, Fachreza Aryo; Akbar, Avicenna

doi:10.26452/ijrps.v11i4.4107

Cited by 2 publications

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“…Based on in vitro studies, curcumin has antiproliferative and antitumorigenic effects to prevent proliferation and migration of vascular smooth muscle, neointima hyperplasia, and stenosis that causes the failure of AVF maturation (Yang et al, 2006). Curcumin also shows anti-in lammatory and antioxidant properties that may contribute to remodelling and the development of neointima hyperplasia (Pratama et al, 2020;Hewlings and Kalman, 2017). Studies on curcumin in patients with ESRD patient with DM, however, are limited.…”

Section: Introductionmentioning

confidence: 99%

Curcumin anti-inflammatory and antitumorigenic effect on arteriovenous fistula maturation in patient with end-stage renal disease with diabetes mellitus

Pratama

Yuwono

Supriyadi

et al. 2021

ijrps

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The primary clinical problem of arteriovenous fistula (AVF) is the high maturation failure rate. Curcumin shows anti-inflammatory, antioxidant, antitumorigenic, and antiproliferative effects that may contribute to AVF maturation. This study investigated the effectiveness of curcumin and acetylsalicylic acid on anti-inflammatory and antitumorigenic effects on AVF maturation in patients with End-Stage Renal Disease (ESRD) with diabetes mellitus (DM). The present study is a single-blinded, randomized controlled trial consisting of curcumin, acetylsalicylic acid, or placebo intervention for eight weeks. A total of 67 participants completed the intervention. There was a higher level of nitric oxide (NO) between the curcumin and placebo four weeks (92.58±24.70 vs 75.67±16.50 µmol/L, adjusted p = 0.038) and eight weeks (95.27±28.77 vs 76.66±23.24 µmol/L, adjusted p <0.05) postoperatively. Higher-level of NO between acetylsalicylic acid and placebo (93.65±24.65 vs 75.67±16.50 µmol/L, adjusted p = 0.031) four weeks postoperatively. Curcumin increases NO after four and eight weeks and lowers MMP-9 four weeks after AVF operation. Acetylsalicylic acid increases NO four weeks after AVF surgery on ESRD patients with DM.

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Section: Introductionmentioning

confidence: 99%