Antioxidants for adults with chronic kidney disease

Colombijn, Julia MT; Hooft, Lotty; Jun, Min; Webster, Angela C; Bots, Michiel L; Verhaar, Marianne C; Vernooij, Robin WM

doi:10.1002/14651858.cd008176.pub3

Cited by 5 publications

(3 citation statements)

References 298 publications

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“…Given the multifaceted involvement of oxidative stress in various pathologies, antioxidant therapy is considered extremely significant. However, the expected results are not always obtained in interventions employing antioxidants, including for CKD [61]. Reactive oxygen species are a double-edged sword, having both detrimental effects on the body and being crucial for the body's defense.…”

Section: H2 Intervention For Ckd and Hemodialysismentioning

confidence: 99%

Application of Electrolyzed Hydrogen Water for Management of Chronic Kidney Disease and Dialysis Treatment—Perspective View

Nakayama,

Kabayama,

Miyazaki

2024

Antioxidants

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Chronic kidney disease (CKD), which is globally on the rise, has become an urgent challenge from the perspective of public health, given its risk factors such as end-stage renal failure, cardiovascular diseases, and infections. The pathophysiology of CKD, including dialysis patients, is deeply associated with enhanced oxidative stress in both the kidneys and the entire body. Therefore, the introduction of a safe and widely applicable antioxidant therapy is expected as a measure against CKD. Electrolyzed hydrogen water (EHW) generated through the electrolysis of water has been confirmed to possess chemical antioxidant capabilities. In Japan, devices producing this water have become popular for household drinking water. In CKD model experiments conducted to date, drinking EHW has been shown to suppress the progression of kidney damage related to hypertension. Furthermore, clinical studies have reported that systemic oxidative stress in patients undergoing dialysis treatment using EHW is suppressed, leading to a reduction in the incidence of cardiovascular complications. In the future, considering EHW as one of the comprehensive measures against CKD holds significant importance. The medical utility of EHW is believed to be substantial, and further investigation is warranted.

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Section: H2 Intervention For Ckd and Hemodialysismentioning

confidence: 99%

Application of Electrolyzed Hydrogen Water for Management of Chronic Kidney Disease and Dialysis Treatment—Perspective View

Nakayama,

Kabayama,

Miyazaki

2024

Antioxidants

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“…We suggest that the accumulation of fatty acids occurs due to oxidative damage to the respirasome function. Supplementation with antioxidants can potentially reduce kidney damage [ 64 , 65 , 66 ], however, most of clinical studies do not support the therapeutic effects of “common” antioxidants [ 67 ], which is likely due to the impairment of intrinsic antioxidants such as mitochondrial superoxide dismutase [ 68 ]. One of the best strategies for avoiding kidney dysfunctions is to prevent oxidative stress by ameliorating blood sugar and controlling sodium consumption.…”

Section: Kidneymentioning

confidence: 99%

Critical Role of Mitochondrial Fatty Acid Metabolism in Normal Cell Function and Pathological Conditions

Dikalov,

Panov,

Dikalova

2024

IJMS

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There is a “popular” belief that a fat-free diet is beneficial, supported by the scientific dogma indicating that high levels of fatty acids promote many pathological metabolic, cardiovascular, and neurodegenerative conditions. This dogma pressured scientists not to recognize the essential role of fatty acids in cellular metabolism and focus on the detrimental effects of fatty acids. In this work, we critically review several decades of studies and recent publications supporting the critical role of mitochondrial fatty acid metabolism in cellular homeostasis and many pathological conditions. Fatty acids are the primary fuel source and essential cell membrane building blocks from the origin of life. The essential cell membranes phospholipids were evolutionarily preserved from the earlier bacteria in human subjects. In the past century, the discovery of fatty acid metabolism was superseded by the epidemic growth of metabolic conditions and cardiovascular diseases. The association of fatty acids and pathological conditions is not due to their “harmful” effects but rather the result of impaired fatty acid metabolism and abnormal lifestyle. Mitochondrial dysfunction is linked to impaired metabolism and drives multiple pathological conditions. Despite metabolic flexibility, the loss of mitochondrial fatty acid oxidation cannot be fully compensated for by other sources of mitochondrial substrates, such as carbohydrates and amino acids, resulting in a pathogenic accumulation of long-chain fatty acids and a deficiency of medium-chain fatty acids. Despite popular belief, mitochondrial fatty acid oxidation is essential not only for energy-demanding organs such as the heart, skeletal muscle, and kidneys but also for metabolically “inactive” organs such as endothelial and epithelial cells. Recent studies indicate that the accumulation of long-chain fatty acids in specific organs and tissues support the impaired fatty acid oxidation in cell- and tissue-specific fashion. This work, therefore, provides a basis to challenge these established dogmas and articulate the need for a paradigm shift from the “pathogenic” role of fatty acids to the critical role of fatty acid oxidation. This is important to define the causative role of impaired mitochondrial fatty acid oxidation in specific pathological conditions and develop novel therapeutic approaches targeting mitochondrial fatty acid metabolism.

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“…Supplementation could be another potential option. A recent Cochrane review (2023) found evidence that antioxidant supplementation in patients with chronic kidney disease likely reduces cardiovascular events and progression to kidney failure [92]. No compelling evidence was found regarding mortality risk.…”

Section: General Discussion and Future Perspectivesmentioning

confidence: 99%

Oxidative stress after kidney transplantation

Yepes Calderon

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Antioxidants for adults with chronic kidney disease

Cited by 5 publications

References 298 publications

Application of Electrolyzed Hydrogen Water for Management of Chronic Kidney Disease and Dialysis Treatment—Perspective View

Application of Electrolyzed Hydrogen Water for Management of Chronic Kidney Disease and Dialysis Treatment—Perspective View

Critical Role of Mitochondrial Fatty Acid Metabolism in Normal Cell Function and Pathological Conditions

Oxidative stress after kidney transplantation

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