Antioxidant properties of aqueous extracts of unripe Musa paradisiaca on sodium nitroprusside induced lipid peroxidation in rat pancreas in vitro

Shodehinde, Sidiqat A.; Oboh, Ganiyu

doi:10.1016/s2221-1691(13)60095-7

Cited by 63 publications

(53 citation statements)

References 33 publications

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“…Similarly, green colour showed higher abundance and red colour lower abundance. These chemical components, present in M. × paradisiaca L., might be suitable to act as a drug substance for various diseases such as microbial infection, liver disorders, diabetes, hyperlipidemia, and kidney disease . Also the application as a food preservative or cosmetic ingredient, when antimicrobial and antioxidant activity is exerted by the EOs might be considered.…”

Section: Resultsmentioning

confidence: 99%

TLC‐bioautography identification and GC‐MS analysis of antimicrobial and antioxidant active compounds in Musa × paradisiaca L. fruit pulp essential oil

Fahim

Ibrahim

Zahiruddin

et al. 2019

Phytochemical Analysis

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Introduction The absence of microbial growth and resistance to oxidative deterioration in fruits of Musa × paradisiaca L. (bananas) is an indication of the presence of antimicrobial and antioxidant metabolites. Objective In order to investigate the secondary metabolomic spectrum as well as the active antimicrobial and antioxidants present in essential oils (EOs) from fruits of different geographical areas of M. × paradisiaca, gas chromatography‐mass spectroscopy (GC‐MS) principal component data correlation analysis is complemented with antimicrobial assays and phytochemical and bioautographic antioxidant fingerprints with thin layer chromatography (TLC). Methodology An EO was obtained by steam distillation and subjected to GC‐MS and TLC for metabolomic profiling from fruit pulp. The antimicrobial potential was tested in both Escherichia coli as a gram negative and Bacillus subtilis as a gram positive microbe. Potential antioxidant metabolites were identified through TLC‐bioautography and GC‐MS analysis of active zones. Results A maximum of 0.56% v/w EO was isolated from fruit pulps of M. × paradisiaca. Minimum inhibitory concentrations (MICs) against B. subtillis and E. coli were 0.25 and 0.35 μg/mL, respectively. Thus, 56 metabolites were identified through GC‐MS. The major abundant antimicrobial metabolites found in EOs are α‐thujene, γ‐terpinene, α‐ and β‐pinene, sabinene, β‐myrcene, limonene, α‐capaene, caryophyllene and (Z,E)‐α farnesene. Aceteugenol, palmitic acid, stearic acid, palmitin, and stearin were identified as antioxidant metabolites. Principal component analysis of metabolite data reveals correlations and a clear separation based on metabolites obtained from various areas. Conclusion The data generated using metabolic profiling and cluster analysis helped to identify antimicrobial and antioxidant compounds in M. × paradisiaca.

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Section: Resultsmentioning

confidence: 99%

TLC‐bioautography identification and GC‐MS analysis of antimicrobial and antioxidant active compounds in Musa × paradisiaca L. fruit pulp essential oil

Fahim

Ibrahim

Zahiruddin

et al. 2019

Phytochemical Analysis

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“…Therefore, this study suggests that the PPARD rs7770619 polymorphism is a candidate gene for IFG or T2D because of the association between PPARD and MDA, which is the primary biomarker of freeradical-mediated lipid damage and oxidative stress. 2 The strengths of this study include an association between the PPARD rs7770619 polymorphism and T2D, which is combined with oxidative stress. Moreover, this study is the first to report the association between PPARD SNPs and oxidative stress markers.…”

Section: Diabetes and Vascular Disease Research 15(4)mentioning

confidence: 99%

PPARD rs7770619 polymorphism in a Korean population: Association with plasma malondialdehyde and impaired fasting glucose or newly diagnosed type 2 diabetes

Kim

Yoo

Sun

et al. 2018

Diabetes and Vascular Disease Research

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Both the peroxisome proliferator-activated receptor delta gene (PPARD) and malondialdehyde plasma concentrations may play a role in impaired glucose metabolism. The aim of this work was to determine whether PPARD is a candidate gene for impaired fasting glucose or type 2 diabetes and whether a particular genetic variant shows association with plasma malondialdehyde levels. Among the 10 single-nucleotide polymorphisms that were most strongly associated with malondialdehyde, the rs7770619 polymorphism in PPARD was analysed in 1798 subjects with normal fasting glucose, impaired fasting glucose and newly diagnosed type 2 diabetes. Our data demonstrate that the CT genotype of the rs7770619 is associated with a lower risk of impaired fasting glucose or type 2 diabetes together with lower plasma levels of malondialdehyde in both groups (p < 0.05). Glucose levels and the rs7770619 are significantly associated in individuals with normal fasting glucose, and a trend towards an association between glucose levels and rs7770619 is also observed in individuals with impaired fasting glucose or type 2 diabetes. In conclusion, PPARD rs7770619 is a novel candidate variant for impaired fasting glucose and type 2 diabetes and shows association with malondialdehyde levels. Future work is required to understand the mechanisms for these associations and the clinical implications of our findings.

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“…Moreover, ROS causes oxidation of complex lipids in vivo, synthesized by lipoxygenases as a response to cell injury, typically from hydrogen peroxide. Peroxidation of lipids produces highly reactive aldehydes which includes Malondialdehyde (MDA), predicted as a primary biomarker of free radical mediated lipid damage and oxidative stress [10] . Oxidized lipids are able to generate MDA as a decomposition product and its mechanism involves formation of prostaglandins, like endoperoxides, from polyunsaturated fatty acid (PUFA) with two or more double bonds [11] .…”

Section: Introductionmentioning

confidence: 99%

Association between Serum Malondialdehyde and Insulin in Type 2 Diabetes Mellitus in Eastern India

Khemka¹

2017

jmscr

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Antioxidant properties of aqueous extracts of unripe Musa paradisiaca on sodium nitroprusside induced lipid peroxidation in rat pancreas in vitro

Cited by 63 publications

References 33 publications

TLC‐bioautography identification and GC‐MS analysis of antimicrobial and antioxidant active compounds in Musa × paradisiaca L. fruit pulp essential oil

TLC‐bioautography identification and GC‐MS analysis of antimicrobial and antioxidant active compounds in Musa × paradisiaca L. fruit pulp essential oil

PPARD rs7770619 polymorphism in a Korean population: Association with plasma malondialdehyde and impaired fasting glucose or newly diagnosed type 2 diabetes

Association between Serum Malondialdehyde and Insulin in Type 2 Diabetes Mellitus in Eastern India

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