Antioxidant properties of antiepileptic drugs levetiracetam and clonazepam in mice brain after in vitro-induced oxidative stress

Oliveira, Aline de Albuquerque; Linhares, Maria Isabel; Filho, Adriano JosÃ© Maia Chaves; Rios, Emiliano Ricardo Vasconcelos; Lima, Camila Nayane de Carvalho; Venâncio, Edith Teles; Souza, Alana Gomes de; Lima, Klistenes Alves de; Sousa, Francisca ClÃ©a FlorenÃ§o de; Gaspar, Danielle Macêdo; Fonteles, Marta Maria de FranÃ§a

doi:10.5897/ajpp2015.4358

Cited by 9 publications

(3 citation statements)

References 46 publications

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“…Some studies have shown that antiepileptic drugs can turn redox status of organism toward to favourable form in patient with epilepsy. [35][36][37] Thus, we may have found this balance unchanged in patient group for 2 reasons: 1) antiepileptic drugs may affect this balance favorably, or 2) serum samples were taken during seizure-free period.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of the dynamic thiol-disulphide homeostasis in patients with epilepsy

Gümüşyayla¹,

Vural²,

Bektaş³

et al. 2016

Epilepsi

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Bu çalışmanın amacı epilepsili hastalarda yeni bir oksidatif stress parametresi olarak dinamik tiyol-disülfid homeostazisini araştırmaktır. Gereç ve Yöntem: 50 tanesi epilepsi hastası, 50 tanesi de sağlıklı gönüllü olmak üzere toplam 100 katılımcı çalışmaya dahil edildi. Çalışmaya katılan tüm epilepsi hastaları ve sağlıklı gönüllülerin serumda total tiyol (-SH+-S-S-) ve nativ tiyol (-SH) düzeyleri ölçüldü. Dinamik disülfid bağ düzeyi (-S-S-) ve (-S-S-) x 100 / (-SH), (-S-S-) x 100 / (-SH+-S-S-) ve-SHx100 / (-SH+-S-S-) oranları bu değerlerden hesaplandı. Elde edilen veriler epilepsi hastaları ve sağlıklı gönüllüler arasında kıyaslandı. Bulgular: Epilepsi hastaları ve sağlıklı gönüllüler arasında total tiyol, nativ tiyol miktarları, dinamik disülfid bağ düzeyi ve (-S-S-) x 100 / (-SH), (-S-S-) x 100 / (-SH+-S-S-) ve-SH x 100 / (-SH+-S-S-) oranları arasında istatistiksel olarak anlamlı bir farklılık bulunmadı. Ayrıca hasta grubunda total tiyol, nativ tiyol miktarları, dinamik disülfid bağ düzeyi ve (-S-S-) x 100 / (-SH), (-S-S-) x 100 / (-SH+-S-S-) ve-SH x 100 / (-SH+-S-S-) oranları ile nöbet sıklığı ve hastalık süresi arasında bir korelasyon bulunmadı. Sonuç: Oksidatif stresin epileptogenezin altında yatan moleküler değişikliklerden biri olduğu düşünülür. Bu çalışmada, biz literatürde yeni geliştirilmiş bir metod ile epilepsi hastalarında dinamik tiyol-disülfid homeostazisini araştırdık.

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Section: Discussionmentioning

confidence: 98%

Evaluation of the dynamic thiol-disulphide homeostasis in patients with epilepsy

Gümüşyayla¹,

Vural²,

Bektaş³

et al. 2016

Epilepsi

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“… 8 - 10 In contrast, others showed a protection effect of LEV against oxidative stress in animal models. 11 , 12 On the other hand, some studies showed no effect of these agents on oxidative stress activity. 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

The effect of levetiracetam on depression and anti-oxidant activity in patients with epilepsy

Mehvari‐Habibabadi

Zaré

Aghaye-Ghazvini

et al. 2023

CJN

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Background: Levetiracetam (LEV) is approved for treating epilepsy. The current evidence shows that LEV can cause behavioral problems such as depression. It is well-known that depression is associated with oxidative stress. Therefore, we conducted this study to assess the influence of LEV on depression severity and anti-oxidant status. Methods: In this prospective longitudinal study, 50 patients with diagnosis of epilepsy on LEV were included. We used Beck Depression Inventory-II (BDI-II) to assess depression severity. The serum levels of zinc and glutathione were measured as anti-oxidant markers. These variables were evaluated at the baseline and 3 months after the commencement of LEV. Results: A total of 30 patients finished the follow-up. Among them, 21 patients were women. The mean age at baseline was 28.76 ± 11.37 (range: 16-68 years). The severity of depression at the last follow-up was significantly higher than the baseline. We observed a decrease in the serum levels of zinc and glutathione, though they were not statistically significant. Conclusion: Our results suggest that LEV can increase the risk of depression in patients with epilepsy. This study also suggests that zinc depletion can be induced through act of LEV. Further studies are needed to validate these findings.

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“…Several classes of approved drugs have been studied through the years for their antioxidant properties [ 1 , 5 , 6 ]. Proton pump inhibitors [ 7 ], antidiabetics [ 8 ], drugs acting on the cardiovascular system [ 9 ], antiepileptics [ 10 ], and anti-inflammatory agents [ 11 ] represent some of the investigated classes, which are also paired by antioxidant natural and semi-synthetic compounds with biological activity [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Furthermore, besides therapeutic agents, it must be stressed that bioactive components from diet have been recognized among the risk factors or, on the other hand, protective agents possibly influencing oxidative stress and pathogenesis of related diseases [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Potential of Psychotropic Drugs: From Clinical Evidence to In Vitro and In Vivo Assessment and toward a New Challenge for in Silico Molecular Design

et al. 2020

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Due to high oxygen consumption, the brain is particularly vulnerable to oxidative stress, which is considered an important element in the etiopathogenesis of several mental disorders, including schizophrenia, depression and dependencies. Despite the fact that it is not established yet whether oxidative stress is a cause or a consequence of clinic manifestations, the intake of antioxidant supplements in combination with the psychotropic therapy constitutes a valuable solution in patients’ treatment. Anyway, some drugs possess antioxidant capacity themselves and this aspect is discussed in this review, focusing on antipsychotics and antidepressants. In the context of a collection of clinical observations, in vitro and in vivo results are critically reported, often highlighting controversial aspects. Finally, a new challenge is discussed, i.e., the possibility of assessing in silico the antioxidant potential of these drugs, exploiting computational chemistry methodologies and machine learning. Despite the physiological environment being incredibly complex and the detection of meaningful oxidative stress biomarkers being all but an easy task, a rigorous and systematic analysis of the structural and reactivity properties of antioxidant drugs seems to be a promising route to better interpret therapeutic outcomes and provide elements for the rational design of novel drugs.

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Antioxidant properties of antiepileptic drugs levetiracetam and clonazepam in mice brain after in vitro-induced oxidative stress

Cited by 9 publications

References 46 publications

Evaluation of the dynamic thiol-disulphide homeostasis in patients with epilepsy

Evaluation of the dynamic thiol-disulphide homeostasis in patients with epilepsy

The effect of levetiracetam on depression and anti-oxidant activity in patients with epilepsy

Antioxidant Potential of Psychotropic Drugs: From Clinical Evidence to In Vitro and In Vivo Assessment and toward a New Challenge for in Silico Molecular Design

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