Antioxidant properties, anti-inflammatory effects, and bioactive constituents of the Indian medicinal rice Njavara yellow compared with staple varieties

Parvathy, Rathnam; Mohanlal, Smitha; Pushpan, Chithra K.; Helen, A.; Jayalekshmy, A.

doi:10.1007/s10068-014-0189-y

Cited by 11 publications

(3 citation statements)

References 27 publications

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“…Oxidative stress produced by ROS, which may be induced during inflammatory processes, increases pro‐inflammatory mediators expression (Kang et al., 2020; Murugan et al., 2012). ROS and free radicals are accompanied by the diseases and conditions such as inflammation, aging, neurodegenerative diseases, cancer, rheumatoid arthritis, and arteriosclerosis (Parvathy et al., 2014). To counteract harmful effects, antioxidants, which protect the body, need to be balanced against the generation of free radicals.…”

Section: Introductionmentioning

confidence: 99%

Acai berry extract as a regulator of intestinal inflammation pathways in a Caco‐2 and RAW 264.7 co‐culture model

Kim

Jin

et al. 2021

J Food Biochem

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The aim of this study was to assess the anti‐inflammatory effects of acai berries in a Caco‐2 and RAW 264.7 macrophage co‐culture model. The acai berry extract (ABE) was prepared using 70% ethanol, and total anthocyanin, polyphenol, and flavonoid contents in ABE were analyzed. To the antioxidant activity of ABE, we measured radical scavenging activity as well as ferric reducing antioxidant power values. Prior to inducing inflammation, Caco‐2 cells were co‐cultured with RAW 264.7. Inflammation was induced using lipopolysaccharides (LPS) in RAW 264.7 cells. The transepithelial electrical resistance value was significantly recovered and the mRNA level of tight junction proteins, including ZO‐1, JAM‐1, and claudin‐4, tended to increase compared with that in the LPS group. LPS‐induced interleukin (IL)‐6, IL‐8, and prostaglandin E2 levels reduced significantly following treatment with the highest ABE concentration. In the highest ABE concentration, the phosphorylation of p65, p38 mitogen‐activated protein kinase, and c‐Jun N‐terminal kinase was downregulated compared with the LPS group. The phosphorylation of extracellular signal‐regulated kinase showed a decreased tendency. These results suggest that acai berry may improve gastrointestinal health. Practical applications Acai berry is known to have abundant anthocyanin, which has many biological activities, including anti‐inflammatory, antioxidant, antihypertensive, and anticytotoxic/cytoprotective activities. This study demonstrated the anti‐inflammatory effects of acai berry extracts via TEER value, expression of tight junction protein, and production of inflammatory mediators and cytokines in the Caco‐2 and RAW 264.7 co‐culture model. Therefore, acai berry has the potential to prevent intestinal inflammatory diseases.

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Section: Introductionmentioning

confidence: 99%

Acai berry extract as a regulator of intestinal inflammation pathways in a Caco‐2 and RAW 264.7 co‐culture model

Kim

Jin

et al. 2021

J Food Biochem

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“…Various bioactivities of tricin, including antioxidant activity, anti-inflammatory activity, , anticancer activity, antiangiogenic activity, and antidiabetic activity, have been reported . In terms of safety, no sign of toxicity was observed in mice after being fed 1 g tricin/kg diet for 5 consecutive days …”

Section: Introductionmentioning

confidence: 99%

Antiobesity Effect of Tricin, a Methylated Cereal Flavone, in High-Fat-Diet-Induced Obese Mice

Lee

Imm

2018

J. Agric. Food Chem.

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The antiobesity potential of tricin, a methylated cereal flavonoid, was examined using a high-fat-diet-induced obese mice model. The body weight ( P < 0.01) and body fat mass ( P < 0.05) were significantly decreased in the high-dose tricin supplementation group (TH: 200 mg/kg diet) in comparison to the high fat diet control group (CON) after a 12-week feeding trial. The serum (60.9 ± 2.09 mg/dL) and hepatic triglyceride levels (45.3 ± 4.42 nmol/mg protein) in the TH group were significantly decreased in comparison to the CON group (78.3 ± 5.09 mg/dL, 76.3 ± 8.10 nmol/mg protein), respectively. This antiobesity effect was attributed to a decrease in the expression of lipogenic markers crucial for fat synthesis in the liver (fatty acid synthase, stearoyl-CoA desaturase 1, elongation of long-chain fatty acids family member 6, glycerol-3-phosphate acyltransferase, and diglyceride acyltransferase) and suppressed expression of transcription factors associated with adipocyte differentiation (peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding protein α). These lipid-lowering effects are mediated by the activation of adenosine 5'-monophosphate-activated protein kinase.

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“…Jyothi and Uma were used for the study. Studies on the nutraceutical properties of Black Njavara, Golden Njavara, Jyothi, Uma and Jaya have been carried out earlier [5][6][7][8][9] . The seeds of Pokkali were collected from the Rice Research Station, Vyttila; Jyothi was sourced from Regional Agricultural Research Station, Pattambi; Uma, Black Njavara and Golden Njavara from Rice Research Station, Moncompu and Jeerakasala and Gandhakasala were obtained from Regional Agricultural Research Station, Ambalavayal.…”

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confidence: 99%

Comparative Analysis of Grain Quality and Nutraceutical Properties of Selected Rice Varieties from Kerala

Shylaraj¹,

Nadh²,

Chandran³

2018

Current Science

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Kerala, the land of rich biodiversity, is a treasure of land races of many crops. The speciality rice varieties of Kerala include Pokkali (organic rice), Jeerakasala and Gandhakasala (scented rice varieties), Black Njavara and Golden Njavara (medicinal rice varieties). A study on the nutraceutical properties of these speciality rice varieties was made to understand their health benefits. Oil content in the rice bran and antioxidants like oryzanol, tocopherol and tocotrienol in the rice bran oil (RBO) of these rice varieties were estimated and compared apart from the quality and nutritional analysis of both rice and bran. The study revealed that the bran is rich in RBO and antioxidants like oryzanol, tocopherol and tocotrienol which may contribute to its high therapeutic value. The study recommends minimum polishing of these rice varieties during milling for consumption purpose. As the bran is rich in fibre and micronutrients like Fe, Cu, B and S, it should be utilized for the preparation of valueadded products like biscuits, baby foods, breads, etc. for healthy human consumption. The study envisages an urgent need for the utilization of the huge quantity of rice bran oil and as component of other food products.

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Antioxidant properties, anti-inflammatory effects, and bioactive constituents of the Indian medicinal rice Njavara yellow compared with staple varieties

Cited by 11 publications

References 27 publications

Acai berry extract as a regulator of intestinal inflammation pathways in a Caco‐2 and RAW 264.7 co‐culture model

Acai berry extract as a regulator of intestinal inflammation pathways in a Caco‐2 and RAW 264.7 co‐culture model

Antiobesity Effect of Tricin, a Methylated Cereal Flavone, in High-Fat-Diet-Induced Obese Mice

Comparative Analysis of Grain Quality and Nutraceutical Properties of Selected Rice Varieties from Kerala

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