Antiobesity Effect of Tricin, a Methylated Cereal Flavone, in High-Fat-Diet-Induced Obese Mice

Abstract

The antiobesity potential of tricin, a methylated cereal flavonoid, was examined using a high-fat-diet-induced obese mice model. The body weight ( P < 0.01) and body fat mass ( P < 0.05) were significantly decreased in the high-dose tricin supplementation group (TH: 200 mg/kg diet) in comparison to the high fat diet control group (CON) after a 12-week feeding trial. The serum (60.9 ± 2.09 mg/dL) and hepatic triglyceride levels (45.3 ± 4.42 nmol/mg protein) in the TH group were significantly decreased in comparison to the CON group (78.3 ± 5.09 mg/dL, 76.3 ± 8.10 nmol/mg protein), respectively. This antiobesity effect was attributed to a decrease in the expression of lipogenic markers crucial for fat synthesis in the liver (fatty acid synthase, stearoyl-CoA desaturase 1, elongation of long-chain fatty acids family member 6, glycerol-3-phosphate acyltransferase, and diglyceride acyltransferase) and suppressed expression of transcription factors associated with adipocyte differentiation (peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding protein α). These lipid-lowering effects are mediated by the activation of adenosine 5'-monophosphate-activated protein kinase.

Herbal Combination of Phyllostachys pubescens and Scutellaria baicalensis Inhibits Adipogenesis and Promotes Browning via AMPK Activation in 3T3-L1 Adipocytes

“…Chlorogenic acid was previously shown to inhibit adipocyte differentiation via AMPK activation [39,40]. Tricin suppressed the expression of transcription factors associated with adipocyte differentiation (PPARγ and C/EBPα) in obese mice fed a high-fat diet [41]. Collectively, the results suggest that these compounds are responsible for the anti-adipogenic activity of BS21.…”

Eriocalyxin B Inhibits Adipogenesis in 3T3-L1 Adipocytes by Cell Cycle Arrest

“…Traditional medicinal plants have huge natural compound resources and better safety in drug development and application. At present, several studies revealed the effective natural compounds of antiobesity are extracted from botany, including sulforaphene [12], daidzein [13], quercetin [14], hesperidin and capsaicin [15], methylated cereal flavonoid [16], and dietary phenolic [17], indicating the natural products are a great choice as potential candidates for treatment of obesity.…”

Isolation of Tricin as a Xanthine Oxidase Inhibitor from Sweet White Clover (Melilotus albus) and Its Distribution in Selected Gramineae Species

“…Tricin is a flavonoid-type compound that has diverse properties, including antioxidant, anti-obesity, antidiabetic, anticancer, anti-influenza virus, anti-human cytomegalovirus, anti-inflammatory, antiangiogenic, antifungal, anti-adipogenic, insecticidal, and allelopathic activities [ 14 , 18 , 19 , 20 ]. However, it has not been reported to have inhibitory activity on XO.…”