Antioxidant properties and phenolic variation in wild populations of Marrubium vulgare L. (Lamiaceae)

Boulila, Abdennacer; Sanaa, Adnen; Salem, Intidhar Ben; Nesrine, Rokbeni; M’Rabet, Yassine; Hosni, Karim; Fernández, Xavier

doi:10.1016/j.indcrop.2015.07.069

Cited by 41 publications

(49 citation statements)

References 32 publications

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“…In particular antioxidant properties may justify the widespread of Marrubium vulgare extracts, often prepared with peculiar extraction techniques, as natural cosmetic ingredients, with claims including anti-pollution, antioxidant, protective for irritated and stressed skin, detoxifying, soothing. Reported results suggest a remarkable antioxidant activity of M. vulgare extracts assessed with different methods (DPPH • radical scavenging, scavenging activity against hydrogen peroxide, iron reducing power) [95][96][97]. In order to correlate this antioxidant activity to specific bioactive compounds, phytochemical composition of M. vulgare has been extensively investigated; these studies, conducted on different types of extracts, led to the identification of a wide array of phytochemical compounds, such as flavonoids, terpenoids and phenylethanoid glycosides.…”

Section: Marrubium Vulgarementioning

confidence: 99%

Cosmetic Functional Ingredients from Botanical Sources for Anti-Pollution Skincare Products

Juliano

Magrini

2018

Cosmetics

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Air pollution is a rising problem in many metropolitan areas around the world. Airborne contaminants are predominantly derived from anthropogenic activities, and include carbon monoxide, sulfur dioxide, nitrogen oxides, volatile organic compounds, ozone and particulate matter (PM; a mixture of solid and liquid particles of variable size and composition, able to absorb and delivery a large number of pollutants). The exposure to these air pollutants is associated to detrimental effects on human skin, such as premature aging, pigment spot formation, skin rashes and eczema, and can worsen some skin conditions, such as atopic dermatitis. A cosmetic approach to this problem involves the topical application of skincare products containing functional ingredients able to counteract pollution-induced skin damage. Considering that the demand for natural actives is growing in all segments of global cosmetic market, the aim of this review is to describe some commercial cosmetic ingredients obtained from botanical sources able to reduce the impact of air pollutants on human skin with different mechanisms, providing a scientific rationale for their use.

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Section: Marrubium Vulgarementioning

confidence: 99%

Cosmetic Functional Ingredients from Botanical Sources for Anti-Pollution Skincare Products

Juliano

Magrini

2018

Cosmetics

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“…; Boulila et al . ). Among them the genus Origanum (Lamiaceae family) is considered one of the most important herbs used in folk medicine.…”

Section: Introductionmentioning

confidence: 97%

Antioxidant Activity andα-Amylase Inhibitory Effect of Polyphenolic-Rich Extract fromOriganum GlandulosumDesf

Béjaoui

Boulila²,

Sanaa

et al. 2016

Journal of Food Biochemistry

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The polyphenolic-rich extract of Tunisian Origanum glandulosum Desf. was investigated for its phenolic composition, antioxidant activity and potential to contribute to the dietary management of type II diabetes. By mean of an ultraperformance liquid chromatography-electrospray ionization-mass spectrometry (UPLC-PDA-ESI-MS) 16 phenolics were characterized. The major detected compounds are caffeic acid, luteloin glucoside, xanthomicrol and carvacrol. The polyphenolic-rich extract presented a notable antioxidant activity similar to that of the synthetic antioxidant Trolox. It was found to inhibit, in a concentration dependent manner, the a-amylase activity with an IC 50 value (8.22 mg/mL) comparable to that of Acarbose (6.12 mg/mL).Overall, our findings suggest that O. glandulosum could be considered as a valuable source of high-value phytochemicals with pharmaceutical and functional food additive applications. PRACTICAL APPLICATIONSOriganum glandulosum Desf., a North African endemic species, is one of the most used plants in folk medicine against whooping cough, fever, bronchitis and diabetes. In the present work, the ability of O. glandulosum to inhibit pancreatic a-amylase in vitro as well as to act as antioxidant food was investigated. The results suggest that O. glandulosum could be considered as a valuable source of phytochemicals with a potent a-amylase inhibition property and antioxidant capacity. Further animal and clinical studies were needed to confirm the potential use of O. glandulosum for the management of type II diabetes.

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“…Recent literature has evidenced that Marrubium vulgare shows several in vivo and in vitro activities including antihypertensive, antioxidant, antiinflammatory, antidiabetic, effects on respiratory system, digestive stimulant, antiasthmatic, hypolipidemic, antibacterial, and antifungal effects. Within this context, and as a part of our current research in this field, in the present contribution we focused on M. vulgare L. (white/common horehound), an annual herbaceous plant belonging to Lamiaceae family, native to Eurasia and northern Africa zones . Due to its biological activities, the European Medicines Agency has published a monograph for M. vulgare in which all the traditional, non‐clinical and clinical data are reported .…”

Section: Introductionmentioning

confidence: 99%

The use of a microwave‐assisted solvent extraction coupled with HPLC‐UV/PAD to assess the quality of Marrubium vulgareL. (white horehound) herbal raw material

Martino

Volpe

Cavalloro

et al. 2019

Phytochemical Analysis

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Introduction Marrubium vulgare is a herbal remedy presents in several European Pharmacopoeias and commonly marketed as white horehound. The chemotaxonomic marker of Marrubium genus is marrubiin and its content may change in response to biotic and abiotic stress. Objective Development of a microwave‐assisted solvent extraction (MASE) methodology suitable for exhaustively extracting marrubiin from M. vulgare leaves, easily applicable to large sets of samples. Evaluation of the influence of copper(II) on marrubiin production. Material and methods M. vulgare leaves were dried, extracted exploiting MASE and analysed via high‐performance liquid chromatography ultraviolet photodiode array detection (HPLC‐UV/PAD) system. A design of experiments approach was adopted to select the best extraction conditions. Extraction parameters (solvent composition, extraction time and temperature), were studied applying two full factorial experimental designs in a sequential approach. To analyse samples, a rapid HPLC‐UV/PAD method was set up. Results The best results in terms of marrubiin extraction yield were obtained extracting samples at 120°C with 100% ethanol, for 15 min (3 × 5 min microwave cycles). The developed methodology was successfully applied to matrices grown in Greenhouse conditions and under stress induced by copper(II), selected as model agent for abiotic stress. Progressively decreasing production of marrubiin was evidenced in connection with treatment with 80, 200 and 300 mg/L copper sulphate. Conclusion An efficient methodology for the extraction and determination of the amount of marrubiin in large sets of samples of M. vulgare plants was developed. Results demonstrated that marrubiin is an easily detectable marker useful for evaluating M. vulgare reaction to stress.

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Antioxidant properties and phenolic variation in wild populations of Marrubium vulgare L. (Lamiaceae)

Cited by 41 publications

References 32 publications

Cosmetic Functional Ingredients from Botanical Sources for Anti-Pollution Skincare Products

Cosmetic Functional Ingredients from Botanical Sources for Anti-Pollution Skincare Products

Antioxidant Activity andα-Amylase Inhibitory Effect of Polyphenolic-Rich Extract fromOriganum GlandulosumDesf

The use of a microwave‐assisted solvent extraction coupled with HPLC‐UV/PAD to assess the quality of Marrubium vulgareL. (white horehound) herbal raw material

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