Antioxidant Potential and Wound Healing Activity of Biosurfactant Produced by Acinetobacter junii B6

Ohadi, Mandana; Forootanfar, Hamid; Rahimi, Hamid Reza; Jafari, Elham; Shakibaie, Mojtaba; Eslaminejad, Touba; Dehghannoudeh, Gholamreza

doi:10.2174/1389201018666171122121350

Cited by 51 publications

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“…Ohadi et al . () in their study of wound healing in rats showed that the LP produced by Acinetobacter junii B6 increased free‐radical scavenging activities and improved histopathological remission. Lydon et al .…”

Section: Health‐related Applicationsmentioning

confidence: 96%

“…It has been suggested that the wound healing properties exhibited by those LPs investigated may be as a result of their ability to reduce oxidative stress through the prevention of reactive oxygen species production. Ohadi et al (2017) in their study of wound healing in rats showed that the LP produced by Acinetobacter junii B6 increased free-radical scavenging activities and improved histopathological remission. Lydon et al (2017) tested a highly purified preparation of micelleforming nonacetylated acidic SL that contained 90% C18 congener suggesting that acidic SLs can be used as a component of antimicrobial creams to reduce the risk of wound infection during healing.…”

Section: Applications In Wound Healingmentioning

confidence: 99%

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Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

et al. 2019

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Synthetic surfactants are becoming increasingly unpopular in many applications due to previously disregarded effects on biological systems and this has led to a new focus on replacing such products with biosurfactants that are biodegradable and produced from renewal resources. Microbially derived biosurfactants have been investigated in numerous studies in areas including: increasing feed digestibility in an agricultural context, improving seed protection and fertility, plant pathogen control, antimicrobial activity, antibiofilm activity, wound healing and dermatological care, improved oral cavity care, drug delivery systems and anticancer treatments. The development of the potential of biosurfactants has been hindered somewhat by the myriad of approaches taken in their investigations, the focus on pathogens as source species and the costs associated with large‐scale production. Here, we focus on various microbial sources of biosurfactants and the current trends in terms of agricultural and biomedical applications.

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Section: Health‐related Applicationsmentioning

confidence: 96%

Section: Applications In Wound Healingmentioning

confidence: 99%

Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

et al. 2019

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“…83 Several studies evaluated the potency of different antioxidant agents from herbal and bacterial resources as well as chemically produced ones for elevating the healing rate of chronic wounds. 84 Considering the great effect of antioxidant agents in healing of wound, the healing activity of entrapped Se NPs and VE into PCL/GEL scaffolds as materials with high antioxidant capacity was evaluated in the present study. According to Figure 10(a), the MDA level of tissues treated with PCL/GEL/Se NPs (0.078 µM/mg protein, p-value ≤ 0.01) and PCL/GEL/Se NPs/VE (0.059 µM/mg protein, p-value ≤ 0.001) was significantly lower than negative control (0.13 µM/mg protein).…”

Section: Resultsmentioning

confidence: 99%

Bioactive anti-oxidative polycaprolactone/gelatin electrospun nanofibers containing selenium nanoparticles/vitamin E for wound dressing applications

et al. 2021

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In this study, polycaprolactone/gelatin (PCL/GEL) electrospun nanofibers containing biogenic selenium nanoparticles (Se NPs) and Se NPs/vitamin E (VE) with average diameters of 397.8 nm and 279.5 nm, respectively (as determined by SEM inspection) were prepared and their effect on wound healing was evaluated using in-vivo studies. The energy dispersive X-ray (EDX) mapping, TEM micrograph, and FTIR spectra of the prepared nanofibers strongly demonstrated well entrapment of Se NPs and VE into scaffolds. An amount of 57% Se NPs and 43% VE were gradually released from PCL/GEL/Se NPs/VE scaffold after 4 days immersion in PBS solution (pH 7.4). The both PCL/GEL/Se NPs and PCL/GEL/Se NPs/VE scaffolds supported 3T3 cell proliferation and attachment as confirmed by MTT assay and SEM imaging. Complete re-epithelialization, low level of edema and inflammatory cells in coordination with high level of oriented collagens demonstrated the wound healing activity of PCL/GEL/Se NPs/VE. Besides, significant antioxidant efficacy of PCL/GEL/Se NPs and PCL/GEL/Se NPs/VE scaffolds was demonstrated according to GSH and MDA assays. To sum up, the prepared PCL/GEL/Se NPs/VE scaffold in the present study represented suitable healing effect on animal model which candidate it for further studies.

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“…The FRAP values were expressed as micromoles per liter (µM) and a standard curve that showed millimole Fe 2+ to absorbance was used to read these values. 28…”

Section: Total Antioxidant Capacity Assaymentioning

confidence: 99%

<p>Radioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation</p>

Rezaeifar

Jomehzadeh

et al. 2019

DDDT

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Introduction: The ionizing radiation exposure of the normal cell causes damage to DNA, which leads to cell dysfunction or even cell death. However, it is necessary to identify new radio protectives in order to protect normal cells. Sulindac sulfide (SS) is a metabolite of sulindac (a non-steroidal anti-inflammatory drug) known as a cyclooxygenase inhibitor. Free radicals and reactive oxygen species are generated in the IR-exposed cells. Also, the induced inflammation process causes damage in DNA. Purpose: In this research, the radioprotective effect of SS was investigated against genotoxicity and lipid peroxidation induced by ionizing radiation in the human blood lymphocytes. Methods: In this study, the human blood samples were pretreated with SS at different concentrations (10, 25, 50, 100 and 250 μM) and then were exposed to IR at a dose of 1.5 Gy. The micronucleus (MN) assay was used to indicate the radioprotective effects of SS on exposed cells. Total antioxidant activity of the SS was measured by using FRAP and DPPH assay. Also, the malondialdehyde (MDA) levels and the activity of superoxide dismutase (SOD) on the exposed cells were evaluated. Results: It was found that SS decreased the percentage of MN induced by IR in exposed cells. Maximum reduction in the frequency of MN was observed at 250 μM of SS (87%) that provides the highest degree of protection against IR. On the other hand, pretreatment at 250 μM of SS inhibited IR-induced oxidative stress, which led to a decrease in the MN frequencies and MDA levels, while SOD activity showed an increase in the exposed cells. Conclusion: It could be concluded that SS as a good radioprotective agent protects the human normal cells against the oxidative stress and genetic damage induced by IR.

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Antioxidant Potential and Wound Healing Activity of Biosurfactant Produced by Acinetobacter junii B6

Abstract: • DPPH and FRAP assays showed notable scavenging activity. • MDA, H2O2, and GSH; confirmed the scavenging property of the derived biosurfactant through ROS. • Synthesized formula encourages the healing of the wound because of its antioxidant capacity.

Cited by 51 publications

References 0 publications

Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

Bioactive anti-oxidative polycaprolactone/gelatin electrospun nanofibers containing selenium nanoparticles/vitamin E for wound dressing applications

<p>Radioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation</p>

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