Antioxidant lipoate and tissue antioxidants in aged rats

Arivazhagan, Palaniyappan; Thilakavathy, Thangaswamy; Panneerselvam, Chinnakkannu

doi:10.1016/s0955-2863(99)00079-0

Cited by 93 publications

(53 citation statements)

References 50 publications

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“…The increase in markers of lipid peroxidation products due to hyperglycemia has been previously reported in tissues of diabetic rats and suggested to partly contribute to long-term tissue damage. [32][33][34][35] MA has previously been shown to decrease nitric oxide levels, another potent tissue oxidant, therefore supporting our current findings. 36 This outcome of S. aromaticum-derived MA is similar to that of rutin, a polyphenolic flavonoid in diabetic rat.…”

Section: Discussionsupporting

confidence: 92%

Antioxidant effects of maslinic acid in livers, hearts and kidneys of streptozotocin-induced diabetic rats: effects on kidney function

et al. 2013

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Studies indicate that hyperglycemia-induced oxidative stress triggers the development of microvascular and macrovascular complications in diabetes. Accordingly, we hypothesized that maslinic acid (MA) prevents these complications due to its antioxidant properties. We, therefore, investigated the effects of 5-week MA treatment of streptozotocin (STZ)-induced diabetic rats on anti-oxidative status of cardiac, hepatic and renal tissues as well as on kidney function. Proximal tubular effects of MA were studied in anesthetized rats challenged with hypotonic saline after a 3.5 h equilibration for 4 h of 1 h control, 1.5 h treatment and 1.5 h recovery periods using lithium clearance. MA was added to the infusate during the treatment period. Oral glucose tolerance responses to MA were monitored in rats given a glucose load after an 18 h fast. Compared with untreated diabetic rats, MA-treated diabetic animals exhibited significantly low malondialdehyde (MDA, a marker of lipid peroxidation) and increased the activity of antioxidant enzymes; superoxide dismutase and glutathione peroxidase in hepatic, cardiac and renal tissues. The expressions of gastrocnemius muscle GLUT4 and kidney GLUT1 and GLUT2 were assessed to elucidate the mechanism of the hypoglycemic effects of MA. MA-treatment diminished the expression of GLUT1 and GLUT2 in diabetic kidney and reduced glycemia values of diabetic rats. MA administration increased urinary Na þ outputs and additionally the FE Na indicating that at least part of the overall reduction in Na þ reabsorption occurred in the proximal tubules. These results suggest antioxidant effects of MA can ameliorate oxidative stress and improve kidney function in diabetes mellitus.

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Section: Discussionsupporting

confidence: 92%

Antioxidant effects of maslinic acid in livers, hearts and kidneys of streptozotocin-induced diabetic rats: effects on kidney function

et al. 2013

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“…In order to protect cells from oxidative damage, aerobic metabolism generally depends on a stringent control of ROS by antioxidants. Decline in antioxidant enzymes activities with ageing has been well documented [39][40][41]. Similarly, in the present study, significant lower activities of these enzymes were recorded in the aged rats.…”

Section: Discussionsupporting

confidence: 86%

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

Azman

Zakaria

Othman

et al. 2018

Journal of Taibah University for Science

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The neuroprotective effects of Tualang honey in stress-induced young and aged rats were investigated. Tualang honey (200 mg/kg body weight) was administered for 28 days. Stressinduced rats were subjected to loud noise 100 dB(A) 4 hours daily for 14 days. Stress exposure significantly induced memory impairment, increased brain oxidation indices, and decreased antioxidant enzymes activities and neuronal density in mPFC, CA2 and CA3 hippocampal areas in both young and aged rats. The stressed rats treated with Tualang honey showed a significant decrease in stress hormone levels and brain oxidation indices, and increase in memory, antioxidant enzymes activities, and neuronal density in mPFC and hippocampus compared to the vehicle-treated stressed rats. The protective effect of Tualang honey was more prominent in young than aged rats. These results suggest the neuroprotective effects of Tualang honey against oxidative stress and memory decline due to stress exposure and/or ageing through its antioxidant property. ARTICLE HISTORY

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“…In addition ALA enhances glucose uptake by cells, followed by increment of cellular nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate levels which is leading to increase the activity of CAT [10]. Also it has been demonstrated that administration of ALA could increase GPX-Px activity followed by increase intracellular GSH levels [8,10]. Some evidences indicate that ALA might suppress cell death through GSH synthesis [54].…”

Section: Discussionmentioning

confidence: 99%

“…It appears that increase TAC levels in the presence of ALA is due to affect on nerve growth factor (NGF) which in turn induce expression of superoxide dismutase gene that result in increase of SOD [8]. In addition ALA enhances glucose uptake by cells, followed by increment of cellular nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate levels which is leading to increase the activity of CAT [10]. Also it has been demonstrated that administration of ALA could increase GPX-Px activity followed by increase intracellular GSH levels [8,10].…”

Section: Discussionmentioning

confidence: 99%

The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles

Talebi

Zavareh

Kashani

et al. 2012

J Assist Reprod Genet

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Purpose This study was designed to investigate the effect of alpha-lipoic acid (ALA) on reactive oxygen species (ROS) production, total antioxidant capacity (TAC) and developmental competence of cultured pre-antral follicles derived from mouse ovarian tissue. Methods Pre-antral follicles were isolated from immature mouse ovaries and were cultured in α-minimal essential medium supplemented with different concentrations (0, 50, 100, 250 and 500 uM) of ALA. Follicular growth, oocyte maturation and embryo development were evaluated. Separately, ROS and TAC were measured after 0, 24, 48, 72 and 96 h of culture with spectrofluorometery and ferric reducing/antioxidant power (FRAP) assay, respectively. Results In the presence of 100 uM ALA, developmental rates of follicles, oocytes and embryos were significantly higher than other groups (p<0.05). At 96 h after culture, a decrease in ROS and an increase in TAC were observed in ALA group compared to control group (p<0.05). Conclusion ALA (100 uM) improves the in vitro development of follicles. This effect may be mediated by decreasing ROS concentration and increasing follicular TAC level during the culture period.

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Antioxidant lipoate and tissue antioxidants in aged rats

Cited by 93 publications

References 50 publications

Antioxidant effects of maslinic acid in livers, hearts and kidneys of streptozotocin-induced diabetic rats: effects on kidney function

Antioxidant effects of maslinic acid in livers, hearts and kidneys of streptozotocin-induced diabetic rats: effects on kidney function

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles

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