Antioxidant intervention attenuates oxidative stress in children and teenagers with Down syndrome

Parisotto, Eduardo Benedetti; Garlet, Thais Regina; Cavalli, Vera Lúcia de Liz Oliveira; Zamoner, Ariane; Rosa, Júlia Salvan da; Bastos, Juliana; Micke, Gustavo Amadeu; Fröde, Tânia Sílvia; Pedrosa, Rozangela Curi; Filho, Danilo Wilhelm

doi:10.1016/j.ridd.2014.03.013

Cited by 28 publications

(27 citation statements)

References 53 publications

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“…As a promising perspective, an antioxidant intervention with vitamins E and C might attenuate the persistence of the systemic oxidative stress in such patients, as already demonstrated by our group in different chronic diseases, such as in chagasic patients with chronic cardiopathy (Maçao et al, 2007), hepatitis C (Farias et al, 2012), and children with Down Syndrome (Parisotto et al, 2014).…”

Section: Discussionsupporting

confidence: 53%

Systemic oxidative stress in victims of Bothrops snakebites

Strapazzon

Parisotto

Moratelli

et al. 2015

JAB

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Section: Discussionsupporting

confidence: 53%

Systemic oxidative stress in victims of Bothrops snakebites

Strapazzon

Parisotto

Moratelli

et al. 2015

JAB

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“…We previously demonstrated that DS individuals presented depleted levels of GSH (Parisotto et al, 2014). The induction of GGT and G6PD activity found in the present study is probably counteracting the GSH depletion.…”

supporting

confidence: 71%

“…The enzymatic activity of SOD, which was higher (47%) in DS patients before antioxidant supplementation, reached values close to controls (46% decrease) after administration of the antioxidant vitamins (Parisotto et al, 2014). Interestingly, even after cessation of the antioxidant intervention, this value remained relatively constant.…”

Section: Resultsmentioning

confidence: 79%

“…In two recent accompanied papers by Garlet et al (2013) and Parisotto et al (2014), both from our laboratory, biomarkers of OS were evaluated in blood samples collected from children and teenagers with DS, using the same protocol and experimental design of the present study. However, now the biomarkers of OS were evaluated in the blood of DS patients (n = 21) before (t 0 ) and after a daily antioxidant intervention (vitamin E 400 mg, C 500 mg, E-TABS 1 and Energil C 1 , respectively) during 6 months (t 1 ), as well as after an interruption of the supplementation (also after 6 months) (t 2 ) and after a new supplementation of further 6 months (t 3 ).…”

Section: Methodsmentioning

confidence: 99%

“…We recently demonstrated the efficacy of an antioxidant supplementation during 6 months in attenuating a systemic OS in DS patients (Parisotto et al, 2014). This is a prospective study carried out to verify the persistence effect of the antioxidant intervention in 1.5 years of follow-up in biomarkers of inflammation and OS in the blood of DS children and teenagers.…”

mentioning

confidence: 89%

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Persistence of the benefit of an antioxidant therapy in children and teenagers with Down syndrome

Parisotto

Giaretta

Zamoner

et al. 2015

Research in Developmental Disabilities

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Biomarkers of oxidative stress and inflammation in people witha physical disability treated with a standardized extract ofNasturtium officinale: A randomized, double‐blind, and placebo‐controlled trial

Clemente

Miguel

Gribner

et al. 2020

Phytotherapy Research

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It is well established that plants from the Brassicaceae family, particularly watercress, have been associated to reduce oxidative DNA damage. Nasturtium officinale R. Br (watercress) contains glucosinolates, with anti-inflammatory action and protective effect on human health against oxidative stress. We aimed to evaluate whether the standardized extract of Nasturtium officinale (SENO) is capable of changing biomarkers of oxidative stress and inflammation in people with physical disabilities. 65 people enrolled this study: as a control group composed by; 15 people with no physical disability assessed once, 25 people with physical disabilities using 750 mg/kg/day of SENO, and 25 people with physical disabilities using 750 mg/kg/day of placebo-control for 5 weeks. Biomarkers of oxidative stress and inflammation were analyzed on day 0 and 36. The results indicated that SENO was associated with decreasing levels of lipid peroxidation, protein carbonyl, catalase, superoxide dismutase, and C-reactive protein. Furthermore, the cytokine kit demonstrated below and out of invertible range, which was impossible to detect the inflammatory process. Despite the cytokine kit was not able to detect the inflammation; these data might provide supportive evidence that SENO, have affected positively people with physical disabilities decreasing their biomarkers of oxidative stress and C-reactive protein. Further studies are required.

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Antioxidant intervention attenuates oxidative stress in children and teenagers with Down syndrome

Cited by 28 publications

References 53 publications

Systemic oxidative stress in victims of Bothrops snakebites

Systemic oxidative stress in victims of Bothrops snakebites

Persistence of the benefit of an antioxidant therapy in children and teenagers with Down syndrome

Biomarkers of oxidative stress and inflammation in people witha physical disability treated with a standardized extract ofNasturtium officinale: A randomized, double‐blind, and placebo‐controlled trial

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