Antioxidant hydrolyzed peptides from Manchurian walnut (<i>Juglans mandshurica</i> Maxim.) attenuate scopolamine‐induced memory impairment in mice

Ren, Dayong; Zhao, Fanrui; Liu, Chunlei; Wang, Ji; Guo, Yong; Liu, Jingsheng; Min, Weihong

doi:10.1002/jsfa.9060

Cited by 63 publications

(54 citation statements)

References 48 publications

(91 reference statements)

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“…According to Wang et al, walnut intake improved lipopolysaccharide (LPS)-induced cognitive dysfunction through the regulation of pro-inflammatory mediators, such as NO and prostaglandin E2, and pro-inflammatory cytokines, such as TNF-α, IL-1β, and IL-6 [ 40 ]. Administration of walnut polypeptide maintains the shape of hippocampal CA3 pyramidal neurons through improvement of the cholinergic system and an increase in monoamines neurotransmitters, such as dopamine, norepinephrine, and serotonin [ 41 ]. This cognitive function improvement effect seems to be due to various ellagitannin contained in walnuts.…”

Section: Discussionmentioning

confidence: 99%

Anti-Amnesic Effect of Walnut via the Regulation of BBB Function and Neuro-Inflammation in Aβ1-42-Induced Mice

et al. 2020

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This study was conducted to assess the protective effect of walnut (Juglans regia L.) extract on amyloid beta (Aβ)1-42-induced institute of cancer research (ICR) mice. By conducting a Y-maze, passive avoidance, and Morris water maze tests with amyloidogenic mice, it was found that walnut extract ameliorated behavioral dysfunction and memory deficit. The walnut extract showed a protective effect on the antioxidant system and cholinergic system by regulating malondialdehyde (MDA) levels, superoxide dismutase (SOD) contents, reduced glutathione (GSH) contents, acetylcholine (ACh) levels, acetylcholinesterase (AChE) activity, and protein expression of AChE and choline acetyltransferase (ChAT). Furthermore, the walnut extract suppressed Aβ-induced abnormality of mitochondrial function by ameliorating reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and ATP contents. Finally, the walnut extract regulated the expression of zonula occludens-1 (ZO-1) and occludin concerned with blood–brain barrier (BBB) function, expression of tumor necrosis factor-alpha (TNF-α), tumor necrosis factor receptor 1 (TNFR1), phosphorylated c-Jun N-terminal kinase (p-JNK), phosphorylated nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor (p-IκB), cyclooxygenase-2 (COX-2), and interleukin 1 beta (IL-1β), related to neuroinflammation and the expression of phosphorylated protein kinase B (p-Akt), caspase-3, hyperphosphorylation of tau (p-tau), and heme oxygenase-1 (HO-1), associated with the Aβ-related Akt pathway.

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Section: Discussionmentioning

confidence: 99%

Anti-Amnesic Effect of Walnut via the Regulation of BBB Function and Neuro-Inflammation in Aβ1-42-Induced Mice

et al. 2020

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“…The biological activities of walnut include antiatherogenic and antioxidant activity and anti-inammatory and anti-mutagenic properties. 40,41 The health benets of walnut are usually attributed to their chemical composition, which includes polyphenols, avones, polysaccharides, aminophenols, minerals, and so on. [42][43][44] The peptides from walnut protein hydrolysates exhibited very high antioxidant activities and show angiotensin-converting enzyme inhibitor activity.…”

Section: Discussionmentioning

confidence: 99%

Walnut protein isolates attenuate particulate matter-induced lung and cardiac injury in mice and zebra fish

Zhang

Liu²,

Fan

et al. 2019

RSC Adv.

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“…Indeed, its solid byproduct (meal) of oil extraction process has an important protein content (around 34% on dry matter basis for rapeseed meal, as example), that is extensively produced every year (408 million tons in world in 2018 ( FAO, 2020 )). Peanut ( Hwang et al., 2001 ; 2010 ; Yu et al., 2012 ; Zheng et al., 2012 ), walnut ( Chen et al., 2012 ; Feng et al., 2019 ; Gu et al., 2015 ; Lv et al., 2017 ; Ren et al., 2018 ) and pine nut ( Liang et al., 2017 ; Yang, Li, et al., 2017 ) are the most documented nuts containing antioxidant BP. Leaves ( e.g.…”

Section: Production and Identification Of Antioxidant Bioactive Peptides From Plant Biomassmentioning

confidence: 99%

Production and antioxidant capacity of bioactive peptides from plant biomass to counteract lipid oxidation

Durand

Beaubier

Ilic

et al. 2021

Current Research in Food Science

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Preventing lipid oxidation, especially with the polyunsaturated fat-based products, is a major concern in sectors as agri-food and cosmetic. Even though the efficiency of synthetic antioxidants has been recognized, both consumers and manufacturers are looking for more innovative, healthy and quality products while rejecting synthetic additives due to their concern about safety, along with their environmental impact issues. In this context, plant biomass, which have shown to be rich in compounds, have raised interest for the isolation of novel naturally occurring antioxidants. Among their myriad of molecules, bioactive peptides, which are biologically active sequence of amino acid residues of proteins, seem to be of a great interest. Therefore, the number of identified amino acids sequences of bioactive peptides from plant biomass with potential antioxidant action is progressively increasing. Thus, this review provides a description of 129 works that have been made to produce bioactive peptides (hydrolysate, fraction and/or isolate peptide) from 55 plant biomass, along with the procedure to examine their antioxidant capacity (until 2019 included). The protein name, the process, and the method to concentrate or isolate antioxidant bioactive peptides, along with their identification and/or specificity were described. Considering the complex, dynamic and multifactorial physico-chemical mechanisms of the lipid oxidation, an appropriate in-vitro methodology should be better performed to efficiently probe the antioxidant potential of bioactive peptides. Therefore, the results were discussed, and perspective for antioxidant applications of bioactive peptides from plant biomass was argued.

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Antioxidant hydrolyzed peptides from Manchurian walnut (Juglans mandshurica Maxim.) attenuate scopolamine‐induced memory impairment in mice

Abstract: Experimental results proved that MWHP exhibits potential in improving memory and should be used to develop novel functional food. © 2018 Society of Chemical Industry.

Cited by 63 publications

References 48 publications

Anti-Amnesic Effect of Walnut via the Regulation of BBB Function and Neuro-Inflammation in Aβ1-42-Induced Mice

Anti-Amnesic Effect of Walnut via the Regulation of BBB Function and Neuro-Inflammation in Aβ1-42-Induced Mice

Walnut protein isolates attenuate particulate matter-induced lung and cardiac injury in mice and zebra fish

Production and antioxidant capacity of bioactive peptides from plant biomass to counteract lipid oxidation

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