Antioxidant, genoprotective and immunomodulatory potential of Vitex negundo leaves in experimental arthritis

Lad, Harsha; Joshi, Ankita; Dixit, Deepti; Sharma, H. C.; Bhatnagar, Deepak

doi:10.1007/s13596-016-0234-x

Cited by 8 publications

(7 citation statements)

References 31 publications

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“…The correlation study showed a strong and positive correlation between phytoconstituents and antioxidant properties. Various other studies have indicated a linear relationship between the major phytoconstituents such as total phenolic compounds and antioxidant activity [9,22,23]. A study on Chinese medicinal plants has also shown a positive correlation between antioxidant activity and total phenolic content [24].…”

Section: Discussionmentioning

confidence: 99%

“…The total phenolic, flavonoid and terpenoid content of NATE was determined as described earlier in Lad et al [9]. Briefly, the total phenolic compounds were estimated using the Folin-ciocalteu reagent and amount of phenolic compounds was calculated using propyl gallate (1 mg/ml in distilled water) as standard.…”

Section: Phytoconstituentsmentioning

confidence: 99%

“…Free radical scavenging activity (FRSA) using DPPH, metal chelation activity (MCA) and reducing power of NATE were measured by the method as described earlier [9]. Briefly, The FRSA is based on the reduction of DPPH by the reductants present in the test sample and the decrease in DPPH absorption at 517 nm was measured after 10 min using butylated hydroxyl toluene (BHT) as a reference compound.…”

Section: In Vitro Antioxidant Activitymentioning

confidence: 99%

“…The inhibition of hydroxyl radical induced DNA damage in presence of the extract was measured by the method as described in Lad et al [9]. Briefly, the native conformation of plasmid DNA (pBR 322) is supercoiled form, which turns into open circular or nicked form in the presence of an oxidizing agent.…”

Section: Plasmid Nicking Assaymentioning

confidence: 99%

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Modulation of oxidative stress mediators in the liver of adjuvant induced arthritic rats by Nyctanthes arbor tristis

Lad

Bhatnagar

2017

Clin Phytosci

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Background: Oxidative stress is found as one of the causes in various pathological conditions. It has been proven in many studies that medicinal plants have antioxidant constituents that help in coping with the oxidative stress. Therefore, the present study aimed at evaluating the antioxidant effects of Nyctanthes arbor tristis leaves extract on the liver of Freund's complete adjuvant (FCA) induced arthritis (RA) rat model.

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Section: Discussionmentioning

confidence: 99%

Section: Phytoconstituentsmentioning

confidence: 99%

Section: In Vitro Antioxidant Activitymentioning

confidence: 99%

Section: Plasmid Nicking Assaymentioning

confidence: 99%

See 2 more Smart Citations

Modulation of oxidative stress mediators in the liver of adjuvant induced arthritic rats by Nyctanthes arbor tristis

Lad

Bhatnagar

2017

Clin Phytosci

Self Cite

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“…In addition to the above activities, the leaves of V. negundo may serve as an important source of natural antioxidant and immunomodulatory agent to protect the cells by mitigating oxidative stress induced toxicity to the biomolecules in experimental arthritis [18] .…”

Section: Analgesic Activitymentioning

confidence: 99%

An Exploratory Review of Pharmcological Activities of Notchi Kudineer- A Siddha Herbal Decoction Used in Covid-19

Ragaroobine

Ragavanee

Adaikalam

et al. 2021

Int J Ayu Pharm Res

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COVID-19 Caused by the novel corona virus (SARS-CoV-2), which has already pushed the entire global community to change their priorities towards finding a suitable anti-viral medicine and a vaccine. While most of the countries have started to prescribe vaccines, which show varied levels of efficacy, finding an effective anti-viral medicine against the virus is still in the early stages despite full-fledged research activities at global level. Many countries particularly those having a rich traditional health science background like India and China started to recommend medicines belonging to local health traditions. The public utilization of those medicines also yielded good results in terms of prevention of the viral infection, reducing the severity of disease or/and reducing the number of days required to recover from the disease as perceived and reported by the patients and doctors. In Tamil Nadu, there are more than 80 million populations. Siddha medicine is the most widely used system of traditional medicine. ‘Suram’ is the Tamil word equivalent to the term ‘fever’. Kabasuram (Also known as Aiya suram) is one among the 64 types of fevers mentioned in Siddha symptoms of which are identical to those of COVID-19. “Notchi kudineer”– a Siddha herbal formulation is being used since many centuries for fever and respiratory disorders with remarkable success. This review article attempts to explore the pharmacological evidence in support of the therapeutic usage of “Notchi kudineer” hence justifying its usage in respiratory related illnesses having fever as a main symptom like the current pandemic of COVID-19.

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Plants with Immunomodulatory Potential Described in Ayurveda

Thekkekkoottumughath

2023

Bioprospecting of Tropical Medicinal Plants

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Antioxidant, genoprotective and immunomodulatory potential of Vitex negundo leaves in experimental arthritis

Cited by 8 publications

References 31 publications

Modulation of oxidative stress mediators in the liver of adjuvant induced arthritic rats by Nyctanthes arbor tristis

Modulation of oxidative stress mediators in the liver of adjuvant induced arthritic rats by Nyctanthes arbor tristis

An Exploratory Review of Pharmcological Activities of Notchi Kudineer- A Siddha Herbal Decoction Used in Covid-19

Plants with Immunomodulatory Potential Described in Ayurveda

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