Antioxidant Enzymes in Hypertensive and Hypertriglyceridemic Rats: Effect of Gender

Baños, Guadalupe; Medina-Campos, Omar Noel; Maldonado, Perla D.; Zamora, José; Pérez, Israel; Pavón, Natalia; Pedraza‐Chaverrí, José

doi:10.1081/ceh-200044255

Cited by 24 publications

(21 citation statements)

References 47 publications

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“…These data agree with previous works that suggest a relationship between complex I content and mitochondrial ROS production [15,38]. On the other hand, our results would rule the antioxidant enzymes out as being responsible for the lower ROS production in females and restricted rats, as previously suggested [31]. All in all, our data would confirm that the lower oxidative damage in cardiac muscle of females is principally due to a lower ROS production by complexes I and III, and not to a higher antioxidant capacity.…”

Section: Gender Differences In Ad Libitum Fed Animalssupporting

confidence: 93%

“…The significance of antioxidant enzymes in the modulation of oxidative damage has been previously suggested [6,30], however, the controversy found in the literature regarding antioxidant activities has failed to describe any clear-cut overall pattern concerning the role of gender and CR in their regulation [12,31]. The present results in heart mitochondria demonstrated a lower GPx activity in females than males which decreased by CR, whereas no significant differences were found in MnSOD activities (Table 4).…”

Section: Antioxidant Enzymatic Activitiescontrasting

confidence: 73%

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Caloric restriction and gender modulate cardiac muscle mitochondrial H2O2 production and oxidative damage

Colom

Oliver

Roca

et al. 2007

Cardiovascular Research

148

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Higher mitochondrial differentiation becomes a metabolic adaptation to increase energy efficiency, as what happens in female and CR rats. This adaptation is associated with their lower mitochondrial free radical production and oxidative damage, which could help to understand the mechanism by which these animals exhibit a lower incidence of aging-related disorders, including cardiovascular disease.

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Section: Gender Differences In Ad Libitum Fed Animalssupporting

confidence: 93%

Section: Antioxidant Enzymatic Activitiescontrasting

confidence: 73%

Caloric restriction and gender modulate cardiac muscle mitochondrial H2O2 production and oxidative damage

Colom

Oliver

Roca

et al. 2007

Cardiovascular Research

148

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“…A reduction in the expression of CAT mRNA and Cu-Zn SOD mRNA was found in liver, as well of CAT mRNA in heart (Cavarape et al 2001). In a previous work with HTG animals, the treatment lasted about 20-24 weeks and had a significant effect, lowering the activity of CAT in kidney of the male rats and heart and kidney of females but increasing the levels of SOD in male heart (Baños et al 2005).…”

Section: Discussionmentioning

confidence: 89%

Activities of antioxidant enzymes in two stages of pathology development in sucrose-fed rats

Baños¹,

Medina-Campos²,

Maldonado³

et al. 2005

Can. J. Physiol. Pharmacol.

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The activities of catalase in liver, heart and kidney as well as glutathione peroxidase and superoxide dismutase in liver, heart, kidney, and serum from hypertriglyceridemic and hypertensive female and male rats were measured at 3 and 8 months of daily administration of sucrose in their drinking water. This treatment induces high levels of serum triglycerides, central obesity, moderate hypertension, hyperinsulinemia, and an increase in lipoperoxidation, among other alterations. The experimental periods were chosen on the basis of previous observations: at 3 months the level of serum triglycerides increases significantly above the normal value and remains without major changes thereafter, but the blood pressure only rises significantly at about 4 months in males and 5 months in females. So, at 8 months the rats have been subjected to abnormal conditions for 3-4 months. The effect of these and the influence of sex on levels of antioxidant enzymes were investigated. Both factors, sucrose treatment and sex, were conducive to significant changes in those variables.

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“…In a previous study we demonstrated that sucrose feeding significantly increased oxidative stress and decreased SOD activity in the heart of MS male but not in MS female rats [18]. Studies in human erythrocyte Cu-Zn-SOD have shown that it undergoes a gradual decrease in activity on incubation with glucose [55].…”

Section: Discussionmentioning

confidence: 99%

Association of renal damage and oxidative stress in a rat model of metabolic syndrome. Influence of gender

Pérez-Torres¹,

Roque²,

Hafidi

et al. 2009

Free Radical Research

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This study investigated the association between nephropathy and oxidative stress, by measurement of systolic blood pressure, lipid peroxidation, activities of catalase, manganese- and copper-zinc-superoxide dismutase and endothelial nitric oxide synthase expression and concentrations of nitrates/nitrites in kidneys from rats with Metabolic Syndrome. Weaning female or male rats had 30% sucrose to drink for 24 weeks (Metabolic Syndrome). Modulation by sex hormones was investigated by gonadectomy and hormone replacement. In Metabolic Syndrome, Castrated Metabolic Syndrome + Testosterone males and Ovariectomized Metabolic Syndrome females had increased blood pressure, proteinuria and lipid peroxidation. Nitrates/nitrites and activities of catalase, manganese and copper-zinc-superoxide dismutase decreased vs intact Control, Castrated Metabolic Syndrome males, intact Metabolic Syndrome and Ovariectomized Metabolic Syndrome + Estradiol females. The results suggest that sex hormones modulate the activity of superoxide-dismutase, catalase and endothelial nitric oxide-synthase. Ovariectomy decreased the protection against oxidative stress in females; the opposite occurred in castrated males.

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Antioxidant Enzymes in Hypertensive and Hypertriglyceridemic Rats: Effect of Gender

Cited by 24 publications

References 47 publications

Caloric restriction and gender modulate cardiac muscle mitochondrial H2O2 production and oxidative damage

Caloric restriction and gender modulate cardiac muscle mitochondrial H2O2 production and oxidative damage

Activities of antioxidant enzymes in two stages of pathology development in sucrose-fed rats

Association of renal damage and oxidative stress in a rat model of metabolic syndrome. Influence of gender

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