Antioxidant enzymes, glutathione and lipid peroxidation in peripheral blood of children affected by coeliac disease

Stojiljković, Vesna; Todorović, Ana; Radlovic, Nedeljko; Pejić, Snežana; Mladenovic, Marija; Kasapović, Jelena; Pajović, Snežana B.

doi:10.1258/000456307782268075

Cited by 41 publications

(46 citation statements)

References 32 publications

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“…The activity of GPx depends on the availability of GSH and selenium, the depletion of which was reported in celiac patients. 13,26,27 It appears that a reduction in GSH and selenium levels is followed by a decrease in GPx activity.…”

Section: Results Blood Tests In Controls and Celiac Patientsmentioning

confidence: 99%

Alterations in serum levels of selected markers of oxidative imbalance in adult celiac patients with extraintestinal manifestations - pilot study

Piątek-Guziewicz¹,

Zagrodzki²,

Paśko³

et al. 2017

Polish Archives of Internal Medicine

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Section: Results Blood Tests In Controls and Celiac Patientsmentioning

confidence: 99%

Alterations in serum levels of selected markers of oxidative imbalance in adult celiac patients with extraintestinal manifestations - pilot study

Piątek-Guziewicz¹,

Zagrodzki²,

Paśko³

et al. 2017

Polish Archives of Internal Medicine

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“…Several studies have shown that ROS and oxidative stress are strongly associated with the celiac disease (Dugas et al 2003, Maiuri et al 2003. In our previous papers we investigated the AO status of children affected by the celiac disease (Stojiljković et al 2007(Stojiljković et al , 2009). Since GSH is a main detoxifier of endogenous and exogenous ROS in intestine (LeGrand and Aw 2001), in this study we focused on the role of glutathione redox cycle in celiac patients.…”

Section: Introductionmentioning

confidence: 99%

Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients

Stojiljković

Pejić

Kasapović

et al. 2012

An. Acad. Bras. Ciênc.

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The celiac disease is an autoimmune gastrointestinal disorder caused by gluten from wheat, rye or barley. In genetically predisposed persons, gluten induces the immune-mediated inflammation of small intestinal mucosa. Histological lesions include intraepithelial lymphocytosis, crypt hypertrophy and villous atrophy, resulting in malabsorption of micro-and macronutrients. The only treatment for celiac patients is a permanent gluten-free diet (GFD). Reactive oxygen species (ROS) and oxidative stress are strongly associated with the celiac disease. Glutathione (GSH) is a main detoxifier of endogenous and exogenous ROS in the intestine. In order to explain the role of glutathione redox cycle in celiac patients, we examined the activities of GSHrelated antioxidant (AO) enzymes glutathione peroxidase (GPx) and glutathione reductase (GR), as well as the concentration of GSH in small intestinal biopsies and peripheral blood of children affected by the celiac disease. The concentration of lipid hydroperoxides (LOOH) as markers of oxidative damage was measured in the same samples. The results clearly demonstrate a significant malfunction of GSH redox cycle with a concomitant decrease in the capacity to regenerate GSH and detoxify LOOH in celiac patients, even after several years of GFD. The oral administration of GSH and a diet rich in natural antioxidants, as well as appropriate dietary supplements, could be of great benefit to the patients.

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“…It has been reported that 97% of subjects with CD contain class II HLA genetic markers, predominantly HLA-DQ2, on chromosome 6p21 (Stojiljković et al, 2007). Another study (Odetti et al, 1998), revealed that in 40% of the population, the presence of this haplotype is essential for the development of CD and lack of these alleles, therefore, eliminates the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of glutathione peroxidase and superoxide dismutase enzyme polymorphisms in celiac disease patients

et al. 2014

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ABSTRACT. Celiac disease (CD) is a multifactorial, inflammatory small bowel disorder characterized by nutrient malabsorption resulting from mucosal damage, the latter induced by cereal products like barley, oat, and wheat. Oxidative stress has previously been reported to play an important role in the pathogenesis of CD. In the present study, we aimed to evaluate the frequency of polymorphisms that affects the structure of the enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), with levels being dependent on the amount of oxidative stress and whether or not there is an association with the mutations DQA1*0501, DQB1*0201, and DRB1*04 that are frequently reported for CD. SOD and GSH-Px polymorphisms were investigated by realtime quantitative polymerase chain reaction in 265 cases. Of the 117 cases that had at least one of DQA1*0501, DQB1*0201, or DRB1*04, 98 (83.75%) also had SOD enzyme polymorphisms and 68 (58.12%) also had GSH-Px polymorphisms. In conclusion, although the etiology of CD is not yet entirely clear, many mechanisms have been suggested. This study supports the notion that SOD and GSH-Px polymorphisms are involved in CD development, even though our findings were not Antioxidant enzyme polymorphisms in celiac disease statistically significant, and, furthermore, are influenced at various levels. SOD polymorphisms and activities were more frequently identified than those of GSH-Px.

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Antioxidant enzymes, glutathione and lipid peroxidation in peripheral blood of children affected by coeliac disease

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Cited by 41 publications

References 32 publications

Alterations in serum levels of selected markers of oxidative imbalance in adult celiac patients with extraintestinal manifestations - pilot study

Alterations in serum levels of selected markers of oxidative imbalance in adult celiac patients with extraintestinal manifestations - pilot study

Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients

Evaluation of glutathione peroxidase and superoxide dismutase enzyme polymorphisms in celiac disease patients

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