Antioxidant enzymes and lipid peroxidation in the scalp of patients with alopecia areata

Akar, Ahmet; Arca, Ercan; Erbil, Hakan; Akay, Cemal; Sayal, Ahmet; Gur, AR

doi:10.1016/s0923-1811(02)00015-4

Cited by 93 publications

(118 citation statements)

References 25 publications

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“…Elevated intracelluar GSH levels may have a critical role in protecting cells from oxidative stress and maintaining the immune system in AA. Our results for GSH are similar to Akar et al (13). However, Naziroglu and Kokcam (12) observed that levels of GSH and glutathione peroxidase in both plasma and erythrocytes were statistically reduced in AA patients compared to a control group.…”

Section: Discussionsupporting

confidence: 91%

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Oxidative Stress Biomarkers and Adenosine Deaminase over the Alopecic Area of the Patients with Alopecia Areata

Öztürk¹,

Arıcan²,

Kurutaş³

et al. 2016

Balkan Med J

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Section: Discussionsupporting

confidence: 91%

“…There are a few studies demonstrating an association between the oxidative stress in serum and biopsy samples in AA (10,(12)(13)(14)(15). However, there is no data about the oxidative stress of the skin surface on the lesional area of patients with AA in the literature.…”

mentioning

confidence: 99%

Oxidative Stress Biomarkers and Adenosine Deaminase over the Alopecic Area of the Patients with Alopecia Areata

Öztürk¹,

Arıcan²,

Kurutaş³

et al. 2016

Balkan Med J

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“…OS'nin lipid peroksidasyonuna neden olduğu ve oluşan son ürün malondialdehitin (MDA) endojen proteinlere bağlanıp yapılarını değiştirerek, yeni antijenik oluşumlara yol açtığı ve bunların da otoimmüniteyi tetiklediği düşünülmektedir. Yaptığı mitokondriyal membran hasarı da enzim salgılatarak apopitoza neden olmakta ve otoimmünitenin ortaya çıkmasında etkili olmaktadır (7,9,17). Kılınç (7) da alopesili hastaların skalp dokusunda TBARS, SOD ve GP değerlerini anlamlı olarak yüksek bulmuşlar ve bu değerlerin erken dönemdeki hastalarda, geç döneme göre daha yüksek olduğunu gözlemlemişlerdir.…”

Section: Discussionunclassified

“…Reaktif oksijen türlerinin, oksidanların artması ya da antioksidan savunma mekanizmasındaki yetersizlikler sonucu oksidatif stres (OS) ortaya çıkar (7).…”

Section: Introductionunclassified

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Etyopathogenesis and Oxidative Stress Relationship in Mild Severe Alopecia Areata

Kılınç¹,

Akbaş²,

Yorulmaz³

et al. 2017

tdd

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Amaç: Alopesi areata (AA); skarsız kıl kaybı ile karakterize, rekürren, otoimmün, inflamatuvar bir hastalıktır. Etyopatogenezi tam bilinmemekte, genetik, emosyonel, çevresel faktörler ve otoimmünite suçlanmaktadır. Çalışmadaki amacımız; AA etyopatogenezinde oksidatif stresin rolünü araştırmaktır. Yöntemler: Çalışmaya 37 AA'lı hasta ve kontrol grubu olarak 35 sağlıklı gönüllü dahil edildi. Hasta ve kontrol grubu serum örneklerinde total antioksidan kapasite (TAK) ve total oksidan kapasite (TOK) ölçülerek oksidatif stres indeksi (OSİ) hesaplandı. Bulgular: Hasta grubunun TAK değerlerinin kontrol grubuna göre daha yüksek olduğu belirlendi (p=0,036). İki grup arasında TOK açısından istatistiksel olarak sınırda, anlamsız bir farklılık saptandı (p=0,058). OSİ açısından iki grup arasında anlamlı bir fark yoktu (p=0,270). Sonuç: AA etyopatogenezinde oksidatif stresin rolü olabilir. TAK değerlerindeki artış yama tarzı hafif şiddetli AA'da antioksidan sistemin yeterli çalıştığını düşündürmektedir. Objective: Alopecia areata (AA) is a recurrent, autoimmune, inflammatory disease characterized by loss of scarless hair. The etiopathogenesis is not exactly known, however genetic, emotional, environmental factors and autoimmunity are accused. The aim of the study is to investigate the role of oxidative stress in the etiopathogenesis of AA. Methods: Thirty seven AA patients and thirty five healthy volunteers as control group were included in the study. Oxidative stress index (OSI) was calculated by measuring total antioxidant capacity (TAC) and total oxidant capacity (TOC) in patient and control group serum samples. Results:The TAC values of the patient group were found to be higher than the control group (p=0.036). A nonsignificant difference was found between the two groups statistically bordered by TOC (p=0.058). There was no significant difference between the two groups in terms of OSI (p=0.270). Conclusion: Oxidative stress may play a role in the etiopathogenesis of AA. The increase in TAC values suggests that the antioxidant system works adequately in patch-type mild severe AA.

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Autoimmune, Inflammatory, Atopic, Thyroid, and Psychiatric Outcomes of Offspring Born to Mothers With Alopecia Areata

Lee

Han

et al. 2023

JAMA Dermatol

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ImportanceAlopecia areata (AA) is associated with diverse autoimmune and psychiatric disorders. However, an investigation on the long-term outcomes for offspring born to mothers diagnosed with AA is lacking.ObjectiveTo investigate the risks for autoimmune, inflammatory, atopic, thyroid, and psychiatric outcomes of offspring born to mothers with AA.Design, Setting, and ParticipantsThis retrospective population-based birth cohort study used the linked birth registration database with the Nationwide Health Insurance Service database of Korea. The participants included all newborns born to mothers with 3 or more visits with International Classification of Diseases, Tenth Revision code of L63 and 1:10 birth year, sex, insurance, income, and location of residence–matched control offspring born to mothers without AA during the years from 2003 to 2015. The analysis was conducted from July 2022 to January 2023.ExposureMaternal AA.Main Outcomes and MeasuresThe occurrence of the following diseases was measured in newborns from birth to December 31, 2020: AA, alopecia totalis/universalis (AT/AU), vitiligo, psoriasis, inflammatory bowel disease, rheumatoid arthritis, atopic dermatitis, allergic rhinitis, asthma, hyperthyroidism, hypothyroidism, Graves disease, Hashimoto thyroiditis, attention-deficit hyperactivity disorder, mood disorder, and anxiety disorder. Multivariable Cox proportional hazard analyses were performed with the following covariates: birth year, age, insurance type, income level, location of residence, maternal age, mode of delivery, maternal history of atopic disorders, and autoimmune disorders.ResultsIn total, 67 364 offspring born to 46 352 mothers with AA and 673 640 controls born to 454 085 unaffected mothers were analyzed. The risk of AA (adjusted hazard ratio [aHR], 2.08; 95% CI, 1.88-2.30), AT/AU (aHR, 1.57; 95% CI, 1.18-2.08), vitiligo (aHR, 1.47; 95% CI, 1.32-1.63), atopic disorders (aHR, 1.07; 95% CI, 1.06-1.09), hypothyroidism (aHR, 1.14; 95% CI, 1.03-1.25), and psychiatric disorders (aHR, 1.15; 95% CI, 1.11-1.20) was significantly increased in offspring born to mothers with AA. Among them, 5088 born to mothers with AT/AU were at much greater risk for the development of AT/AU (aHR, 2.98; 95% CI, 1.48-6.00) and psychiatric disorders (aHR, 1.27; 95% CI, 1.12-1.44).Conclusions and RelevanceIn this Korean retrospective population-based birth cohort study, maternal AA was associated with the development of autoimmune/inflammatory, atopic, thyroid, and psychiatric disorders in their offspring. Clinicians and parents need to be aware of the potential for these comorbidities to occur.

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Antioxidant enzymes and lipid peroxidation in the scalp of patients with alopecia areata

Cited by 93 publications

References 25 publications

Oxidative Stress Biomarkers and Adenosine Deaminase over the Alopecic Area of the Patients with Alopecia Areata

Oxidative Stress Biomarkers and Adenosine Deaminase over the Alopecic Area of the Patients with Alopecia Areata

Etyopathogenesis and Oxidative Stress Relationship in Mild Severe Alopecia Areata

Autoimmune, Inflammatory, Atopic, Thyroid, and Psychiatric Outcomes of Offspring Born to Mothers With Alopecia Areata

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