Oxidative Stress Biomarkers and Adenosine Deaminase over the Alopecic Area of the Patients with Alopecia Areata

Öztürk, Perihan; Arıcan, Özer; Kurutaş, Ergül Belge; Mülayim, Mehmet Kamil

doi:10.5152/balkanmedj.2016.16190

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…Oxidative stress has been suggested in the pathogenesis of AA, AGA, and TE . Antioxidants—eg, selenium, carotenoids, and vitamins A, C, and E—are commonly included in supplements.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss

et al. 2023

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ImportanceDespite the widespread use of nutritional supplements and dietary interventions for treating hair loss, the safety and effectiveness of available products remain unclear.ObjectiveTo evaluate and compile the findings of all dietary and nutritional interventions for treatment of hair loss among individuals without a known baseline nutritional deficiency.Evidence ReviewThe MEDLINE, Embase, and CINAHL databases were searched from inception through October 20, 2021, to identify articles written in English with original findings from investigations of dietary and nutritional interventions in individuals with alopecia or hair loss without a known baseline nutritional deficiency. Quality was assessed with Oxford Centre for Evidence Based Medicine criteria. Outcomes of interest were disease course, both objectively and subjectively measured. Data were evaluated from January 3 to 11, 2022.FindingsThe database searches yielded 6347 citations to which 11 articles from reference lists were added. Of this total, 30 articles were included: 17 randomized clinical trials (RCTs), 11 clinical studies (non-RCT), and 2 case series studies. No diet-based interventional studies met inclusion criteria. Studies of nutritional interventions with the highest-quality evidence showed the potential benefit of Viviscal, Nourkrin, Nutrafol, Lamdapil, Pantogar, capsaicin and isoflavone, omegas 3 and 6 with antioxidants, apple nutraceutical, total glucosides of paeony and compound glycyrrhizin tablets, zinc, tocotrienol, and pumpkin seed oil. Kimchi and cheonggukjang, vitamin D3, and Forti5 had low-quality evidence for disease course improvement. Adverse effects were rare and mild for all the therapies evaluated.Conclusions and RelevanceThe findings of this systematic review should be interpreted in the context of each study’s design; however, this work suggests a potential role for nutritional supplements in the treatment of hair loss. Physicians should engage in shared decision-making by covering the potential risks and benefits of these treatments with patients experiencing hair loss. Future research should focus on larger RCTs with active comparators.

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“…Oxidative stress has been suggested in the pathogenesis of AA, AGA, and TE . Antioxidants—eg, selenium, carotenoids, and vitamins A, C, and E—are commonly included in supplements.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss

et al. 2023

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“…Indeed, oxidative stress has been linked to AA (284,285) as patients' blood and scalp samples show higher levels of serum nitric oxide, and total oxidant capacity as well as lower levels of superoxide dismutase (p<0.001), glutathione peroxidase (p<0.001), and total antioxidant capacity. The level of imbalance was also correlated with disease severity, with higher levels of oxidative stress in more severe cases (95% CI 1.43-0.71) (284,286,287). Furthermore, GWAS studies looking at the underling genes involved in AA have found a link to the antioxidant enzyme PRDX5, which has also been associated with MS (4).…”

Section: Influence Of Environmental Factors During the Lifespanmentioning

confidence: 99%

Differential impact of environmental factors on systemic and localized autoimmunity

2023

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The influence of environmental factors on the development of autoimmune disease is being broadly investigated to better understand the multifactorial nature of autoimmune pathogenesis and to identify potential areas of intervention. Areas of particular interest include the influence of lifestyle, nutrition, and vitamin deficiencies on autoimmunity and chronic inflammation. In this review, we discuss how particular lifestyles and dietary patterns may contribute to or modulate autoimmunity. We explored this concept through a spectrum of several autoimmune diseases including Multiple Sclerosis (MS), Systemic Lupus Erythematosus (SLE) and Alopecia Areata (AA) affecting the central nervous system, whole body, and the hair follicles, respectively. A clear commonality between the autoimmune conditions of interest here is low Vitamin D, a well-researched hormone in the context of autoimmunity with pleiotropic immunomodulatory and anti-inflammatory effects. While low levels are often correlated with disease activity and progression in MS and AA, the relationship is less clear in SLE. Despite strong associations with autoimmunity, we lack conclusive evidence which elucidates its role in contributing to pathogenesis or simply as a result of chronic inflammation. In a similar vein, other vitamins impacting the development and course of these diseases are explored in this review, and overall diet and lifestyle. Recent work exploring the effects of dietary interventions on MS showed that a balanced diet was linked to improvement in clinical parameters, comorbid conditions, and overall quality of life for patients. In patients with MS, SLE and AA, certain diets and supplements are linked to lower incidence and improved symptoms. Conversely, obesity during adolescence was linked with higher incidence of MS while in SLE it was associated with organ damage. Autoimmunity is thought to emerge from the complex interplay between environmental factors and genetic background. Although the scope of this review focuses on environmental factors, it is imperative to elaborate the interaction between genetic susceptibility and environment due to the multifactorial origin of these disease. Here, we offer a comprehensive review about the influence of recent environmental and lifestyle factors on these autoimmune diseases and potential translation into therapeutic interventions.

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“…Oxidative stress may also contribute to the pathophysiology of FPHL as shown for (i) dermal papilla cells from frontal as compared to occipital scalps of androgenetic alopecia patients in vitro 36 and for (ii) scalp scrapes from affected patients and healthy controls presenting significant higher activity of superoxide dismutase, and catalase, or higher levels of reduced glutathione and malondialdehyde in vivo. 37 Therefore, the antioxidative capacity of Pycnogenol ® might also contribute to the observed positive effects on hair density.…”

Section: Resultsmentioning

confidence: 99%

An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study

Cai¹,

Zeng²,

Lin³

et al. 2023

Health Science Reports

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Background and Aims Female pattern hair loss affects females of all ages with a trend to increase after menopause. This disorder may have significant psychological impact and lead to anxiety and depression. Objective In a single center, double blind, randomized, placebo‐controlled study, the effects of oral Pycnogenol® intake (3 × 50 mg/day for a total of 6 months) on hair density, scalp microcirculation, and a variety of skin physiological parameters was studied in Han Chinese menopausal women (N = 76) in Shanghai, China. Methods Measurements were taken at the beginning and after 2 and 6 months, respectively. Hair density was determined by digital photographs and further evaluated by Trichoscan software. Transepidermal water loss was measured by a humidity sensor in a closed chamber on the skin surface. Changes in microcirculation were detected as resting flux on the scalp by reflection photoplethysmography. Results Pycnogenol® intake significantly increased hair density by 30% and 23% after 2 and 6 months of treatment, respectively, as detected by Trichoscan® evaluation of digital photographs. Interestingly, photoplethysmography revealed that this beneficial effect was associated with a decrease in resting flux of the scalp skin, which might indicate an improvement of microcirculation. None of these effects were observed in the placebo taking group. In addition, a significant transient decrease of transepidermal water loss was observed in scalp skin under Pycnogenol,® but not placebo treatment. Conclusion Oral intake of Pycnogenol® might have the potential to reduce hair loss in postmenopausal women.

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Oxidative Stress Biomarkers and Adenosine Deaminase over the Alopecic Area of the Patients with Alopecia Areata

Cited by 7 publications

References 25 publications

Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss

Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss

Differential impact of environmental factors on systemic and localized autoimmunity

An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study

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