Antioxidant enzymatic system in HIV-infected patients

Delmas-Beauvieux, Marie-Christine; Peuchant, Evelyne; Couchouron, Anne; Constans, J.; Pellegrin, Jean‐Luc; Sergeant, Claire; Simonoff, M.; Leng, B; Conn, Costa; Clerc, M.

doi:10.1016/0021-9150(95)96535-z

Cited by 5 publications

(5 citation statements)

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“…These effects appear to be related to persistent tumor necrosis factor-α (TNF-α) activation in HIV-infected patients. HIV-infected individuals have been shown to decrease antioxidant concentrations, disruption in glutathione metabolism, and enhanced spontaneous generation of ROS [3,11,29]. Furthermore, a significant decrease in GR levels was documented.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Oxidative Stress Markers and Antioxidant Imbalance in HIV Infection and AIDS Patients

et al. 2009

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The aim of this study was to investigate lipid peroxidation as evidenced by thiobarbutric acid reactive substances (TBARS), ceruloplasmin (Ce), CD 4+ cells counts and antioxidant, and micronutrients status in HIV infection and AIDS patients. The level of plasma and erythrocyte TBARS, plasma ceruloplasmin was markedly increased in the AIDS patients when compared to HIV infection and healthy control subjects. We observed a significant reduction in CD 4+ cell count in HIV/AIDS patients when compared to control subjects. The activities of erythrocyte antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), and reduced glutathione (GSH), were significantly decreased in AIDS patients when compared with HIV infection and healthy subjects. Significantly low levels of plasma GSH, vitamin A (β-carotene), vitamin C, vitamin E, serum uric acid, albumin, selenium and zinc were also observed in AIDS patients when compared with HIV positive patients and control subjects. The study highlights the occurrence of lipid peroxidation and possible breakdown of antioxidant status in HIV/AIDS patients, which may subsequently increase the possibility of poor immunity. The antioxidant status was progressively depleted in HIV infected persons as the disease progressed from a symptomatic state to AIDS.

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Section: Discussionmentioning

confidence: 99%

Enhanced Oxidative Stress Markers and Antioxidant Imbalance in HIV Infection and AIDS Patients

et al. 2009

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“…Many studies have indicated that the concentrations of GSH and GSSG are influenced by various diseases, with a tendency to decrease the ratio GSH/GSSG (see Table 1). Nevertheless it is evident that the measured concentrations for both GSH and GSSG are highly divergent among different research groups, so these findings should be reconsidered once obtained a general agreement about the physiological levels of these compounds [45,[73][74][75][76][77][78][79][80].…”

Section: Oxidative Stressmentioning

confidence: 99%

Chromatographic and mass spectrometric analysis of glutathione in biological samples

Iwasaki

Saito

Nakano

et al. 2009

Journal of Chromatography B

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“…Liver functional blood flow is a part of total liver blood flow that enters the liver sinusoid includes in the metabolic process [12]. actually it can only be determine by assay of patients with extrahepatic obstruction there was no significant serum SDH activity detectable although the patients were markedly jaundiced and although several of the other serum enzymes studied, such as SGOT, SGPT, and SLDH, were elevated [20][21][22]27].…”

Section: Resuts and Discussionmentioning

confidence: 99%

Evaluation of Sorbitol Dehydrogenase and Some Biochemical Parameters in Patients with Hepatitis.

Mohammad¹,

Saeed²,

Ali³

2019

KUJSS

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This research was concerned with a study of the relationship between sorbitol dehydrogenase and hepatitis disease. Blood samples have been drawn from (35) patients with hepatitis and (28) blood samples of healthy as control group ages ranges from (40-65) years. Patients were collected from Al-Salam Hospital in Mosul City under the supervision of specialists Live in Mosul city. Sorbitol dehydrogenase, total serum bilirubin, protein, albumin, globulin and alanine aminotransferase sGPT were measured in blood of these patients. The results showed a significant increase in sorbitol dehydrogenase, sGPT, bilirubin, total serum protein, albumin and globulin levels compared with the control group. There was also study of the relationship between (SDH) activity and the studied parameters in patient group and finding that there are liner correlation coefficient. the results indicated that, there was a positive significant correlation between the activity of enzyme and each of the total protein, albumin, globulin, sGPT, and bilirubin and negative significant corolation between SDH and globulin.

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Antioxidant enzymatic system in HIV-infected patients

Cited by 5 publications

References 0 publications

Enhanced Oxidative Stress Markers and Antioxidant Imbalance in HIV Infection and AIDS Patients

Enhanced Oxidative Stress Markers and Antioxidant Imbalance in HIV Infection and AIDS Patients

Chromatographic and mass spectrometric analysis of glutathione in biological samples

Evaluation of Sorbitol Dehydrogenase and Some Biochemical Parameters in Patients with Hepatitis.

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