Enhanced Oxidative Stress Markers and Antioxidant Imbalance in HIV Infection and AIDS Patients

Pasupathi, Palanisamy; Ramchandran, T.; Sindhu, P. J.; Saranavan, G.; Bakthavathsalam, Govindaswamy

doi:10.3329/jsr.v1i2.2295

Cited by 29 publications

(21 citation statements)

References 25 publications

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“…The present study revealed a decrease in the level of SOD in serum of HIV/ AIDS patients than control group but this decrease was statistically insignificant [27,28] . Such decrease may be due to its detoxification of released ROS (superoxide anion).…”

Section: Discussionmentioning

confidence: 81%

Antioxidant Status in HIV Positive Pregnant Women

Rajekar¹

2017

JMSCR

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GR, GPx, SOD, MDA and total antioxidant in non pregnant, normal pregnant and HIV positive pregnant women. The activity in non pregnant women and normal pregnant women were 9.27 ±1.74, 47.30 ± 10.27, 1329.7 ± 111.8, 3.03 ± 0.49, 1.47 ± 0.18 and 4.37 ± 0.79, 27.17 ± 2.76, 944.9 ± 193.1, 4.50 ± 0.32, 1.19 ± 0.20 respectively. And the activity was 3.51 ± 1. 15, 19.54 ± 2.51, 675.3 ± 125.9, 5.46 ± 0.55, and 0.88 ± 0.15

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Section: Discussionmentioning

confidence: 81%

Antioxidant Status in HIV Positive Pregnant Women

Rajekar¹

2017

JMSCR

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“…WHO (2011) reports showed that HIV infections evolved to acquired immune deficiency syndrome (AIDS) accompanied by opportunistic infections, severe metabolic and immune dysfunctions. Articles from Sonnerborg et al (1988), Stephens (2004), Pasupthi et al (2009), Coaccioli, et al (2010), Awodele et al (2012) and our group Gil et al (2003) have shown that humans infected with HIV are under chronic immune activation characterized by increase generation of ROS and perturbations of the antioxidant defence system. Oxidative stress (OS) has been detected in many tissues of HIV infected individuals using different biochemical's markers and diverse biotechniques.…”

Section: Introductionmentioning

confidence: 74%

“…Oxidative stress (OS) has been detected in many tissues of HIV infected individuals using different biochemical's markers and diverse biotechniques. In research studies by Sonnerborg et al (1988), Stephens (2004), Pasupthi et al (2009), Coaccioli, et al (2010), Awodele et al (2012), Redhage et al (2009), Stephensen, et al (2007) and Wanchu et al (2009) the OS characterization has been made in populations from several countries and different risk groups using case-controls, cross-sectional and interventions studies. These researches show imbalance in redox status during the infection course which could be related to oxidative molecular damage, viral replication, micronutrient deficiency and inflammatory chronic response, all of them implicated in cellular apoptosis and decreased immune proliferation.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Associated to Disease Progression and Toxicity during Antiretroviral Therapy in Human Immunodeficiency Virus Infection

Valle¹,

Hernández²,

Ávila³

2013

JVM

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Oxidative stress condition arises during imbalance between oxidants and antioxidants of diverse origin damaging both structure and function of tissues. Oxidative stress has been suggested as a cofactor during Human Immunodeficiency Virus Infection course involved in many aspects of disease pathogenesis as viral replication, inflammatory responses, decreased immune cell proliferation, loss of immune function, cellular apoptosis, chronic weight loss, and increased sensitivity to drug toxicity.In this review, we provide an overview of the oxidative metabolism pathways involved in HIV infection, examine the potential impact of antirretroviral toxicity on oxidative damage and argue how the response contribute to co-morbidities. Moreover, we also discuss recent reports from observational and interventional studies which have led to an increasing interest in the possible benefits of micronutrient supplementation as a cost-effective strategy for improving oxidative and nutritional status in HIV infection. The general strategy and combination of these interventions represent an important complementary deal for HIV infection treatment in the era of high active antiretroviral therapy.

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“…Since cellular redox status is a normal physiological variable, any imbalance may elicit cellular response through proliferation, transcriptional activation, or apoptosis [17]. For this reason, recent reports suggest that OS is a principal mechanism in the progression of AIDS [21][22][23].…”

Section: Hiv: An Oxidative Rolementioning

confidence: 99%

“…However, the discovery of HIV also led to a broadening of the view that ROS play a critical role in the expression of HIV and the development of AIDS [20]. It has been reported that the virus induces OS by disturbing cellular antioxidant defense and initiating oxidative reactions [21]. Advanced cases of HIV infection renders individuals susceptible to opportunistic infections, which take advantage of the progressive immunodeficiency caused by HIV.…”

Section: Hiv: An Oxidative Rolementioning

confidence: 99%

Oxidants and Antioxidants in the Pathogenesis of HIV/AIDS

Agarwal¹

2011

TORSJ

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Human immunodeficiency virus (HIV) has predominantly been considered the main cause in the progression of acquired immunodeficiency syndrome (AIDS). However, many researchers believe that there are co-factors involved along the way that may play a critical role in its development. Elevated levels of reactive oxygen species (ROS) have been established to be present at the onset of infection. Additionally, the delayed response by the immune system upon infection may be due to an initial depletion of antioxidants, which play a critical role in scavenging excess ROS to maintain normal physiological conditions. This pro-oxidant/antioxidant imbalance results in a condition known as oxidative stress (OS). OS has been reported to be an integral element in the progression of many diseases, including AIDS. Therefore, it is presumed that antioxidant treatment may provide a promising and cost-effective therapeutic approach in treating HIV-infected individuals on a global scale.Although HIV infection presents one of the most arduous complications to humans worldwide, awareness of its origin, adverse effects, and potential treatment remain confined to a limited population. The aim of this article is to inform the reader of how AIDS developed into a global epidemic so rapidly, while emphasizing the relationship between oxidants and antioxidants in the pathogenesis of HIV/AIDS. A basic review of reduction/oxidation (redox) reactions is provided to understand how such simple introductory concepts can have such profound effects on the body. This serves as an essential building block to the topics that follow: ROS, antioxidants, and OS in HIV disease. Moreover, it allows for us to better define and elucidate OS as an often-overlooked link between HIV-infection and the progression of AIDS, as well as potential antioxidant treatment.

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Enhanced Oxidative Stress Markers and Antioxidant Imbalance in HIV Infection and AIDS Patients

Cited by 29 publications

References 25 publications

Antioxidant Status in HIV Positive Pregnant Women

Antioxidant Status in HIV Positive Pregnant Women

Oxidative Stress Associated to Disease Progression and Toxicity during Antiretroviral Therapy in Human Immunodeficiency Virus Infection

Oxidants and Antioxidants in the Pathogenesis of HIV/AIDS

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