Antioxidant Effects of Vitamin C on Biomedical UHMWPE Compounds

Souza, Vênia Camelo de; Fim, Fabiana de Carvalho; Lima, Maria Edvania A.; Silva, Lucineide Balbino da

doi:10.1002/masy.201800002

Cited by 6 publications

(6 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This solution was then filtered using filter paper and a homogenous mixture was obtained. To remove traces of the wetting medium, the mixture was then dried in an oven at 79 ° C. The dried powder was mixed with Vitamin-C, as performed by Souza et al 30 The fabrication process of composite samples are shown in Figure 2. The samples were fabricated by compression technique using a hot press machine at a pressure of 200 bar.…”

Section: Materials and Experimentsmentioning

confidence: 99%

Biotribological performance of medical-grade UHMW polyethylene-based hybrid composite for joint replacement

Hussain

Ahmad

Saleem

2021

Polymers and Polymer Composites

View full text Add to dashboard Cite

Ultra high molecular weight polyethylene (UHMWPE) is widely used for articulating surfaces in total hip and knee replacements. In the present work, the tribological properties of UHMWPE-based nano composites were studied in order to meet the demands of current bearing applications. UHMWPE matrix reinforced with 0.5, 1, and 2 weight percentage of alumina nano powder were fabricated by hot pressing. The dispersion and microstructure of composite material was established by X-ray diffraction (XRD) and scanning electron microscope (SEM) micrograph. The tests were carried out on a reciprocating sliding pin-on-disc tribometer at human body temperature (37±1°C) under dry and human serum lubricating environments for a normal load of 46 N and 52 N, a constant sliding speed of 4 mm. Under these testing conditions, it has been observed that the wear behavior of the developed composites improved with increase in weight percentage of alumina nano powder. The results show that at 52 N load, the maximum value of wear rate was 7.9x10−7 mm3/Nm and the minimum value 1.6x10−7 mm3/Nm was obtained. SEM was used to examine the worn surface and it was observed that human serum adheres to the surface of the composite pins upon sliding, resulting in the formation of a film which results in better wear resistance of the composite pins under human serum lubrication than dry sliding. This study implies that the use of nano alumina power will reduce the wear of UHMWPE based composite under human serum lubrication.

show abstract

Section: Materials and Experimentsmentioning

confidence: 99%

Biotribological performance of medical-grade UHMW polyethylene-based hybrid composite for joint replacement

Hussain

Ahmad

Saleem

2021

Polymers and Polymer Composites

View full text Add to dashboard Cite

show abstract

“…This result showed that the addition of vitamin E did not alter the chemical characteristics of STD. Different results were observed upon the incorporation of vitamin E ( 31 ) and vitamin C ( 32 ) into standard UHMWPE. The main differences were observed between unworn non-cross-linked and cross-linked acetabular cups.…”

Section: Discussionmentioning

confidence: 99%

Does the addition of vitamin E to conventional UHMWPE improve the wear performance of hip acetabular cups? Micro-Raman characterization of differently processed polyethylene acetabular cups worn on a hip joint simulator

Foggia

Affatato

Taddei

2020

Braz J Med Biol Res

View full text Add to dashboard Cite

In knee replacements, vitamin E-doped ultra-high molecular weight polyethylene (UHMWPE) shows a better wear behavior than standard UHMWPE. Therefore, different sets of polyethylene (PE) acetabular cups, i.e. standard UHMWPE and cross-linked polyethylene irradiated with 50 kGy and 75 kGy, were compared, at a molecular level, with vitamin E-doped UHMWPE to evaluate their wear performance after being tested on a hip joint simulator for five million cycles. Unworn control and worn acetabular cups were analyzed by micro-Raman spectroscopy to gain insight into the effects of wear on the microstructure and phase composition of PE. Macroscopic wear was evaluated through mass loss measurements. The data showed that the samples could be divided into two groups: 1) standard and vitamin E-doped cups (mass loss of about 100 mg) and 2) the cross-linked cups (mass loss of about 30-40 mg). Micro-Raman spectroscopy disclosed different wear mechanisms in the four sets of acetabular cups, which were related to surface topography data. The vitamin E-doped samples did not show a better wear behavior than the cross-linked ones in terms of either mass loss or morphology changes. However, they showed lower variation at the morphological level (lower changes in phase composition) than the UHMWPE cups, thus confirming a certain protecting role of vitamin E against microstructural changes induced by wear testing.

show abstract

“…This chemical reaction‐mediated cross‐linking can effectively compensate for the phenomenon of reduced radiation cross‐linking efficiency caused by the infiltration of antioxidants and further inhibit the reduction of wear resistance based on improving the antioxidant property of the matrix. In addition, α‐tocopherol in VE, VC, Pentaerythritol tetra (3‐[3,5‐di‐tert‐butyl‐4‐hydroxyphenyl] propionate) (PBHP), and r‐Aos were also often added to UHMWPE acetabular cup, and all showed good antioxidant properties 78–81 . During oxidation, many oxidation products are formed, including ketones, hydroperoxides, lactones, esters, carboxylic acids (isolated and associated), ketoacids, and so forth.…”

Section: Methods For Enhancing the Antioxidant Properties Of Polymer ...mentioning

confidence: 99%

“…In addition, α-tocopherol in VE, VC, Pentaerythritol tetra (3-[3,5-di-tert-butyl-4-hydroxyphenyl] propionate) (PBHP), and r-Aos were also often added to UHMWPE acetabular cup, and all showed good antioxidant properties. [78][79][80][81] During oxidation, many oxidation products are formed, including ketones, hydroperoxides, lactones, esters, carboxylic acids (isolated and associated), ketoacids, and so forth. The different behavior of gallic acid (GA) from dodecyl gallate (DG) and VE is attributed to the molecular structures.…”

Section: Antioxidants Additionmentioning

confidence: 99%

Research progress on the oxidation behavior mechanism and the design of antioxidant methods of artificial polymer acetabular cup

Wang

Lin

Dong

et al. 2023

Polymer Engineering & Sci

View full text Add to dashboard Cite

Ultra‐high molecular weight polyethylene (UHMWPE) was once the most widely used clinical hip prosthesis‐bearing component due to its exceptional mechanical qualities and biocompatibility. However, the poor wear resistance of UHMWPE limits its service life in vivo. Radiation cross‐linking is a common means to improve the wear resistance of UHMWPE, and highly cross‐linked polyethylene (HXLPE) acetabular cup is gradually becoming the first choice in clinical practice. The residual free radicals generated by the cross‐linking process can accelerate the oxidation process of the polymer acetabular cup, which is not conducive to the long‐term in vivo service process. Heat treatments such as annealing or melting and the addition of antioxidants are potential methods to improve the antioxidant performance of HXLPE in vivo. Research into the oxidation characteristics of polymer acetabular cup is crucial for enhancing their durability in vivo and ensuring their long‐term performance reliability. In this paper, the research progress focuses on the oxidation mechanism, the influencing factors of the oxidation process of polymer acetabular cups, and the methods to improve their oxidation resistance. It discusses the reliability of improving the service life of UHMWPE acetabular cup in vivo and other alternative methods.Highlights Characteristics of polymer acetabular cups were systematically introduced. Mechanism of oxidative behavior of acetabular cup in vivo/in vitro was analyzed. Influencing factors of acetabular cup oxidation behavior were summarized. Methods for improving antioxidant properties of acetabular cups were summarized. New method was proposed to improve the antioxidant properties of acetabular cup.

show abstract

Antioxidant Effects of Vitamin C on Biomedical UHMWPE Compounds

Cited by 6 publications

References 46 publications

Biotribological performance of medical-grade UHMW polyethylene-based hybrid composite for joint replacement

Biotribological performance of medical-grade UHMW polyethylene-based hybrid composite for joint replacement

Does the addition of vitamin E to conventional UHMWPE improve the wear performance of hip acetabular cups? Micro-Raman characterization of differently processed polyethylene acetabular cups worn on a hip joint simulator

Research progress on the oxidation behavior mechanism and the design of antioxidant methods of artificial polymer acetabular cup

Contact Info

Product

Resources

About