Antioxidant effects of solvent extracts from the dried jujube (Zizyphus jujube) sarcocarp, seed, and leaf via sonication

Kim, Ye-Jin; Son, Dae-Yeul

doi:10.1007/s10068-011-0023-8

Cited by 20 publications

(8 citation statements)

References 24 publications

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“…Consistently, seed extracts of dried jujube (Z. jujuba) obtained with 70% ethanol have been shown to have antioxidant capacity as measured by both ABTS and DPPH radical assays as well as have superoxide dismutase-like activity (20). The brain cells are relatively vulnerable to lipid peroxidation due to plenty of highly oxidizable polyunsaturated fatty acids and large amounts of oxygen consumption (10,21).…”

Section: Resultsmentioning

confidence: 93%

Protective effects of bioactive phenolics from jujube (Ziziphus jujuba) seeds against H2O2–induced oxidative stress in neuronal PC-12 cells

Choi

Lee

et al. 2015

Food Sci Biotechnol

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Section: Resultsmentioning

confidence: 93%

Protective effects of bioactive phenolics from jujube (Ziziphus jujuba) seeds against H2O2–induced oxidative stress in neuronal PC-12 cells

Choi

Lee

et al. 2015

Food Sci Biotechnol

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“…The phenolic content is markedly higher than other plants [ 21 ] and correlates well with the high antioxidant capacity of HRCHs. Likewise, HRCHs have a strong radical scavenging ability—even better than vitamins C and E [ 55 ]. The antioxidant properties are protective against neuronal damage mediated by oxidative stress [ 56 – 59 ].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic, antioxidative, genotoxic and antigenotoxic effects of Horchata, beverage of South Ecuador

Bailón-Moscoso

Tinitana

Martínez-Espinosa

et al. 2017

BMC Complement Altern Med

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Background“Horchata” is an herbal mixture infusion consumed in Southern Ecuador; 66% of its plants are anti-inflammatory medicinal plant, and 51% are analgesics. Anti-inflammatory substances can prevent carcinogenesis mediated by cytotoxic effects and can prevent DNA damage. The aim of this study was to evaluate the cytotoxicity and apoptotic/antigenotoxic effects of horchata as well as its mechanism.MethodsNine different varieties of horchata were prepared in the traditional way and then freeze-dried. Phytochemical screening tested for the presence of secondary metabolites using standard procedures and antioxidant activities. The cytotoxic activity was evaluated on cerebral astrocytoma (D-384), prostate cancer (PC-3), breast cancer (MCF-7), colon cancer (RKO), lung cancer (A-549), immortalized Chinese hamster ovary cells (CHO-K1), and human peripheral blood lymphocytes via a MTS assay. The pro-apoptotic effects were evaluated with Anexin V/Propidium Iodide and western blot of Bax, Bcl-2, TP53, and TP73. Induction and reduction of ROS were assessed by fluorimetry. Genotoxic and antigenotoxic effects were evaluated with a comet assay and micronuclei on binucleated cells.ResultsFive of nine horchatas had cytotoxic effects against D-384 while not affecting normal cells. These horchatas induce cell death by apoptosis modulated by p53/p73. In CHO-K1 cells, the horchatas decrease the damage induced by hydrogen peroxide and Mitomycin C measured in the comet and micronucleus assay respectively.ConclusionsThe IC50 range of effective horchatas in D-384 was 41 to 122 μg·mL−1. This effect may be related to its use in traditional medicine (brain tonic). On the other hand, immortalized Chinese hamster ovary cells (CHO-K1) and lymphocytes did not show a cytotoxic effect. The most potent horchata induced apoptosis via a p53/p73-mediated mechanism.The horchatas present antigenotoxic properties, which may be related to the antioxidant capacity. Future studies on horchata components are necessary to understand the interactions and beneficial properties.

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“…Using DPPH radical scavenging assay and the total reducing capacity model to determine antioxidant activity of 20 jujube varieties, the results showed that jujube extracts all showed good antioxidant capacity [14,15].…”

Section: Antioxidant Capacitymentioning

confidence: 99%

Ziziphus jujuba Mill. 大枣 (Dazao, Common Jujube)

Qiu

Miao

2015

Dietary Chinese Herbs

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Antioxidant effects of solvent extracts from the dried jujube (Zizyphus jujube) sarcocarp, seed, and leaf via sonication

Cited by 20 publications

References 24 publications

Protective effects of bioactive phenolics from jujube (Ziziphus jujuba) seeds against H2O2–induced oxidative stress in neuronal PC-12 cells

Protective effects of bioactive phenolics from jujube (Ziziphus jujuba) seeds against H2O2–induced oxidative stress in neuronal PC-12 cells

Cytotoxic, antioxidative, genotoxic and antigenotoxic effects of Horchata, beverage of South Ecuador

Ziziphus jujuba Mill. 大枣 (Dazao, Common Jujube)

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