Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review

Abrahams, Shameemah; Haylett, William; Johnson, Glynis; Carr, Jonathan; Bardien, Soraya

doi:10.1016/j.neuroscience.2019.02.020

Cited by 212 publications

(143 citation statements)

References 97 publications

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“…Oxidative Medicine and Cellular Longevity in this study, the enhancement of autophagy and the restoration of autophagic flux by CUR might have indirectly played a protective role by scavenging excessive ROS through the aforementioned molecular mechanisms. CUR exerts antioxidant effects by increasing the activities of antioxidant enzymes such as SOD [63]. In this study, our results showed that CUR pretreatment reversed the downregulation of SOD activity induced by TBHP.…”

supporting

confidence: 60%

Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration

Kang

Xiang

Zhan

et al. 2019

Oxidative Medicine and Cellular Longevity

107

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Oxidative stress-induced mitochondrial dysfunction and nucleus pulposus (NP) cell apoptosis play crucial roles in the development of intervertebral disc degeneration (IDD). Increasing studies have shown that interventions targeting impaired autophagic flux can maintain cellular homeostasis by relieving oxidative damage. Here, we investigated the effect of curcumin (CUR), a known autophagy activator, on IDD in vitro and in vivo. CUR suppressed tert-butyl hydroperoxide- (TBHP-) induced oxidative stress and mitochondrial dysfunction and thereby inhibited human NP cell apoptosis, senescence, and ECM degradation. CUR treatment induced autophagy and enhanced autophagic flux in an AMPK/mTOR/ULK1-dependent manner. Notably, CUR alleviated TBHP-induced interruption of autophagosome-lysosome fusion and impairment of lysosomal function and thus contributed to the restoration of blocked autophagic clearance. These protective effects of CUR in TBHP-stimulated human NP cells resembled the effects produced by the autophagy inducer rapamycin, but the effects were partially eliminated by 3-methyladenine- and compound C-mediated inhibition of autophagy initiation or chloroquine-mediated obstruction of autophagic flux. Lastly, CUR also exerted a protective effect against puncture-induced IDD progression in vivo. Our results showed that suppression of excessive ROS production and mitochondrial dysfunction through enhancement of autophagy coupled with restoration of autophagic flux ameliorated TBHP-induced human NP cell apoptosis, senescence, and ECM degradation. Thus, maintenance of the proper functioning of autophagy represents a promising therapeutic strategy for IDD, and CUR might serve as an effective therapeutic agent for IDD.

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supporting

confidence: 60%

Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration

Kang

Xiang

Zhan

et al. 2019

Oxidative Medicine and Cellular Longevity

107

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“…The same is true of the imidazole thiol-containing ovothiol (279,280) . In a similar vein, and although outwith our scope here, we note the potential of other antioxidant natural products such as curcumin (281)(282)(283)(284)(285)(286) .…”

Section: Oxidative Stressmentioning

confidence: 72%

The biology of ergothioneine, an antioxidant nutraceutical

et al. 2020

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Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in mushroom fruiting bodies) and actinobacteria, but is not synthesised by plants and animals who acquire it via the soil and their diet, respectively. Animals have evolved a highly selective transporter for it, known as solute carrier family 22, member 4 (SLC22A4) in humans, signifying its importance, and ERG may even have the status of a vitamin. ERG accumulates differentially in various tissues, according to their expression of SLC22A4, favouring those such as erythrocytes that may be subject to oxidative stress. Mushroom or ERG consumption seems to provide significant prevention against oxidative stress in a large variety of systems. ERG seems to have strong cytoprotective status, and its concentration is lowered in a number of chronic inflammatory diseases. It has been passed as safe by regulatory agencies, and may have value as a nutraceutical and antioxidant more generally.

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“…To repress the expression of daf-16, we used daf- 16 RNAi clone obtained from the Ahringer RNAi library (20). Induction of daf-16 double-stranded RNA was done by adding 0.4 mM isopropyl-β-D-thiogalactoside (IPTG, Sigma-Aldrich, St. Louis, MO, USA) to culture media after OD 600 reached 0.4.…”

Section: Rna Interference (Rnai)mentioning

confidence: 99%

“…It can reduce tumor formation and progression (15). Curcumin also shows protective effect against many chronological diseases, including cardiovascular and neurological diseases (16). A recent study has shown that curcumin can mediate lifespan extension and modulate many age-related biomarkers, including accumulation of lipofuscin, fertility, response to environmental stressors, and cellular ROS production in C. elegans (17).…”

Section: Introductionmentioning

confidence: 99%

Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in <i>Caenorhabditis elegans </i>

Kim

Baek

et al. 2019

DD&T

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Curcumin, a compound found in Indian yellow curry, is known to possess various biological activities, including anti-oxidant, anti-inflammatory, and anti-cancer activities. Cur2004-8 is a synthetic curcumin derivative having symmetrical bis-alkynyl pyridines that shows a strong anti-angiogenic activity. In the present study, we examined the effect of dietary supplementation with Cur2004-8 on response to environmental stresses and aging using Caenorhabditis elegans as a model system. Dietary intervention with Cur2004-8 significantly increased resistance of C. elegans to oxidative stress. Its anti-oxidative-stress effect was greater than curcumin. However, response of C. elegans to heat stress or ultraviolet irradiation was not significantly affected by Cur2004-8. Next, we examined the effect of Cur2004-8 on aging. Cur2004-8 significantly extended both mean and maximum lifespan, accompanying a shift in time-course distribution of progeny production. Age-related decline in motility was also delayed by supplementation with Cur2004-8. In addition, Cur2004-8 prevented amyloid-beta-induced toxicity in Alzheimer's disease model animals which required a forkhead box (FOXO) transcription factor DAF-16. Dietary supplementation with Cur2004-8 also reversed the increase of mortality observed in worms treated with high-glucose-diet. These results suggest that Cur2004-8 has higher anti-oxidant and antiaging activities than curcumin. It can be used for the development of novel anti-aging product.

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Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review

Cited by 212 publications

References 97 publications

Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration

Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration

The biology of ergothioneine, an antioxidant nutraceutical

Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in <i>Caenorhabditis elegans </i>

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