Antioxidant effects of captopril against lead acetate-induced hepatic and splenic tissue toxicity in Swiss albino mice

Abstract

Considering that lead caused a lot of health problems in the world, the present study was carried out to investigate the protective effect of captopril as antioxidants to reduce liver and spleen toxicity induced by lead. Animals were divided into 3 groups, the 1st group served as control group, the 2nd group received 20 mg/kg of lead acetate and the 3rd group received 50 mg/kg of captopril one hour prior to lead administration for 5 days. Results showed that lead intake caused severe alterations in the liver and spleen manifested by hepatocytes degeneration, leukocytic infiltration, fibrosis in liver and moderate to severe liver pathological score. Spleen showed ill-defined architecture, presence of large macrophages and lymphoid necrosis. Administration of captopril reduced hepatotoxicity, liver fibrosis and decrease in pathological scoring system. Moreover, reduced toxicity in spleen is represented by reduction in necrotic areas, more or less healthy lymphoid follicles and decreasing in pathological scoring system.

Ameliorative effect of curcumin on lead‐induced hematological and hepatorenal toxicity in a rat model

“…Previous studies have documented the toxic effects of Pb on biological systems resulting in numerous pathological and clinical consequences with morbidity on almost all the organs with the brain, kidney, and liver being most affected due to their sensitivities. [ 7,39,40 ] These pathological alterations could be due to the increase in oxidative stress, [ 41 ] renal dysfunction, degenerative changes in tubular epithelium, and hepatotoxicity. [ 4,42 ] These changes were also observed in the present study, as the Pb‐induced rats exhibited remarkable alterations in the liver and kidney histology, increased oxidative stress in their serum, and high concentration of Pb in their liver and kidney, aberrations in hematological parameters as well as alteration in liver and kidney enzymes activities.…”

Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Inhibition of Oxidative Stress and Chelating Activity

“…Preceding studies have documented the toxic effects of Pb on biological systems resulting into several pathologies and clinical implications with morbidity on almost all the organs with the brain, kidney and liver serving as primary targets [12,19,20]. These pathological alterations may include increase oxidative stress [9], neurological deficit [21], decrease motor coordination and cognitive deficit [22,23].…”

Effects of Shiga-Toxin Producing Strains of Escherichia coli (STEC), Lead and Bisphenol A Mixture on Kidney and Spleen of Whistler Mice

“…Meanwhile, lead being bivalently charged in its atomic form, displaces other bivalent micromolecules such as Zn 2+ , Cu 2+ and Fe 2+ . In a similar study, Aldahmash et al [32] reported lead intake to cause severe alterations in the kidney and spleen, which was manifested by hepatocytes degeneration, leukocytic infiltration, ill-defined architecture of the spleen, presence of large macrophages and lymphoid necrosis. Hypocellular white pulp, enlargement of venous sinusoids, clustering of heterochromatin in the nucleus, vacuolation in the cytoplasm, swelling of mitochondria and complete distortion of rough endoplasmic reticulum cisterns are also some of the effects of lead [33,34].…”