Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate

Abstract

The present study aims to directly investigate the behavioral and antioxidant effects of simvastatin in a model of bipolar mania induced by lisdexamfetamine dimesylate. Wistar rats were treated for 30 days with simvastatin. On the 24th day after the start of treatment, each rat was administered lisdexamfetamine dimesylate for 7 days. The results suggest that simvastatin combined with lisdexamfetamine dimesylate induced a signifi cant increased locomotion and lisdexamfetamine dimesylate administration causes an oxidative imbalance determined by an increment in lipid peroxidation, protein oxidation and alterations in the activities of antioxidant enzymes in brain areas; moreover, in the presence of simvastatin, most of these effects were prevented. These fi ndings contribute to a better understanding of the critical roles of lisdexamfetamine dimesylate in the treatment of neuropsychiatric disorders, associated with increased oxidative stress and changes in antioxidant enzymatic defense. In view of the central role played by lisdexamfetamine dimesylate, the established antioxidant effect of simvastatin therapy is of major interest.

Differential Therapeutic Effects of Crataegus aronia and Simvastatin on the Hepatocyte Ultrastructure in Hepatic Steatosis

“…2). The lipid lowering (Garcia et al, 2016), antioxidant (Eger et al, 2016) and antiinflammatory (Al-Ani, 2013) effects of simvastatin and the presence of polyphenolic antioxidants, flavonoids, oligomeric flavonoids (proanthocyanidins), and catechins (Kim et al, 2000) in the hawthorn plant could be the reason for the observed substantial treating effects of Crataegus aronia and simvastatin and a better architecture of liver cells.…”

Black Cumin Seed Oil Antidiabetogenic by Increasing Pancreatic P53 Expression

“…Simvastatin, vitamin C, and BCSO can serve as antioxidants and immunomodulators [23,26,27]. BCSO administration with equivalent dose of thymoquinone 68 mg/kgBW shows lower levels of MDA.…”

Andrographolide blocks 50-kHz ultrasonic vocalizations, hyperlocomotion and oxidative stress in an animal model of mania

“…a p < 0.05 compared to all other groups. 2015; Eger et al, 2016), as observed in plasma as well as serum of bipolar patients in manic state (Machado-Vieira et al, 2007;Caldiroli et al, 2020). Thus, the LDX model is a valid procedure for the study of mania and antimanic-like drugs.…”

“…LDX is a long-acting pro-drug of d-amphetamine employed in the therapeutic management of attention deficit/hyperactivity disorder (Ermer et al, 2016). LDX administration has also been used to mimic manic-like behavior in animals (Macêdo et al, 2013;de Souza et al, 2015;Eger et al, 2016;Wendler et al, 2016;Ascoli et al, 2017;Bristot et al, 2019). These manic-like behaviors were reversed or prevented by treatment with lithium or valproate (Macêdo et al, 2013;de Souza et al, 2015;Wendler et al, 2016;Ascoli et al, 2017;Bristot et al, 2019).…”