Antioxidant effect of Phlomis persica Boiss. in rats with streptozotocin-induced diabetes

Sarkhail, Parisa; Fadyevatan, S.; Abdollahi, Mostafa

doi:10.1055/s-0028-1084163

Cited by 2 publications

(2 citation statements)

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“…Today, the utilization of herbal agents is passing a growing route in Asia, Europe, and North Africa as a tonic, anti-diabetic, anti-pyretic, and anti-allergic. Phlomis species such as Phlomis persica boiss or its extract significantly downregulate blood glucose level and are also effective against the complication that occurs due to the lipid peroxidation by antioxidant activity in streptozotocin-induced rats [ 105 ]. Similar investigation exhibited that Bixa orellana (annatto) extract decreased blood glucose levels in fasting normoglycaemic and streptozotocin-induced diabetic dogs by stimulating peripheral utilization of glucose [ 106 ].…”

Section: Herbal Therapies In the Treatment Of Diabetesmentioning

confidence: 99%

Comparative occurrence of diabetes in canine, feline, and few wild animals and their association with pancreatic diseases and ketoacidosis with therapeutic approach

Niaz¹,

Maqbool²,

Khan³

et al. 2018

Vet World

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Diabetes mellitus (DM) is a chronic metabolic disorder in which blood glucose level raises that can result in severe complications. However, the incidence increased mostly by obesity, pregnancy, persistent corpus luteum, and diestrus phase in humans and animals. This review has focused on addressing the possible understanding and pathogenesis of spontaneous DM in canine, feline, and few wild animals. Furthermore, pancreatic associated disorders, diabetic ketoacidosis, hormonal and drug interaction with diabetes, and herbal remedies associated with DM are elucidated. Bibliographic search for the present review was done using PubMed, Scopus, and Google Scholar for articles on concurrent DM in small and wild animals. Persistent corpus luteal and pseudopregnancy in female dogs generate gestational DM (GDM). GDM can also be caused by extensive use of drugs/hormones such as glucocorticosteroids. Although many similarities are present between diabetic cats and diabetic humans which present islet amyloidosis, there was a progressive loss of β- and α-cells and the normal number of δ-cells. The most prominent similarity is the occurrence of islet amyloidosis in all cases of diabetic cat and over 90% of human non-insulin dependent DM Type-2. Acute pancreatic necrosis (APN) occurs due to predisposing factors such as insulin antagonism, insulin resistance, alteration in glucose tolerance, obesity, hyperadrenocorticism, and persistent usage of glucocorticoids, as these play a vital role in the progression of APN. To manage such conditions, it is important to deal with the etiological agent, risk factors, diagnosis of diabetes, and hormonal and drug interaction along with its termination with suitable therapy (herbal) protocols. It should be noted that the protocols used for the diagnosis and treatment of human DM are not appropriate for animals. Further investigations regarding diabetic conditions of pets and wild animals are required, which will benefit the health status of all animals health worldwide.

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Section: Herbal Therapies In the Treatment Of Diabetesmentioning

confidence: 99%

Comparative occurrence of diabetes in canine, feline, and few wild animals and their association with pancreatic diseases and ketoacidosis with therapeutic approach

Niaz¹,

Maqbool²,

Khan³

et al. 2018

Vet World

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“…Reactive oxygen species are by‐products of aerobic metabolism. Free radical attacks biological molecules such as lipids, proteins, enzymes, DNA and RNA, leading to many diseases, such as cancer (1), atherosclerosis (2), aging (3), immunosuppression (4), inflammation (5), ischemic heart disease (6,7), diabetes (8), hair loss (9), Alzheimer’s (10) and Parkinson’s diseases (11). Vitamin C, vitamin E, selenium, β‐carotene, lycopene, lutein and other carotenoids have been used as supplementary antioxidants.…”

mentioning

confidence: 99%

Synthesis of Some N, N′‐Diacylhydrazine Derivatives with Radical‐Scavenging and Antifungal Activity

Liu¹,

Shi²,

Ma³

et al. 2009

Chem Biol Drug Des

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These authors contributed equally to this work.A series of N,N¢-diacylhydrazines were prepared and their structures were confirmed by 1 H NMR, MS and FTICR-MS. They were tested radical-scavenging activity in vitro. The preliminary bioassays of title compounds showed that two compounds had excellent radical-scavenging activity comparable with vitamin C, while the activity is highly relative to the substituents. Surprisingly, several compounds also exhibit favorable fungicidal activities. To further explore the comprehensive structureactivity relationships about the fungicidal activity, a three-dimensional quantitative structure-activity relationship analysis using the method of comparative molecular field analysis was performed.

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Antioxidant effect of Phlomis persica Boiss. in rats with streptozotocin-induced diabetes

Cited by 2 publications

References 0 publications

Comparative occurrence of diabetes in canine, feline, and few wild animals and their association with pancreatic diseases and ketoacidosis with therapeutic approach

Comparative occurrence of diabetes in canine, feline, and few wild animals and their association with pancreatic diseases and ketoacidosis with therapeutic approach

Synthesis of Some N, N′‐Diacylhydrazine Derivatives with Radical‐Scavenging and Antifungal Activity

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