Antioxidant Effect of Ex-maradi Okra Fruit Variety (Abelmuscus esculentus) on Alloxan-Induced Diabetic Rats

Abstract

oxidative damage to membranes and may also enhance susceptibility to lipid peroxidation. 5,6 Trace-element deficiencies or problems with its absorption are frequently associated to chronic diseases. Chronic hyperglycemia may cause significant alterations in the status of some micronutrients, and on the other hand, some of these nutrients can directly modulate glucose homeostasis. 7,8 The early imbalances of some specific metals may play a role in upsetting normal glucose and insulin metabolism. 9 Despite the great strides made in the understanding and management of diabetes, the disease and disease related complications remains unabated. Phytochemicals identified from traditional medicinal plants are presenting an exciting opportunity for the development of new types of therapeutics. 10 Epidemiological studies demonstrated that many phytonutrients from fruits might protect the human body against oxidative stress. It is a known fact that nutrition and health care are interrelated. Thus the consumption of natural antioxidant phytochemicals was noted to have potential health benefits. 11 Abelmoschus esculentus, 'AE" (Okra or lady"s finger) is a flowering plant in the mallow family. It is one of the most important vegetables widely cultivated throughout the tropical and temperate regions of the world for its tender fruits. 12 This plant is popular with its mucilaginous properties and has been acclaimed to have various health benefits which include anti-diabetic properties. 13 Okra is also known for being high in antioxidants activity as it is rich in phenolic compounds with important biological properties like quarcetin and flavonol derivatives, catechin oligomers and hydroxycinnamic derivatives. 14 The fruit of this particular plant is rich in nutrients like protein, niacin, riboflavin, thiamine, folate, vitamins A, B6, C and K, Phosphorus, Zinc, Copper, Potassium, Magnesium, Calcium, and Manganese all of which plays vital role in human diet and health.

In Vitro Antioxidant and Antidiabetic Potentials of the Seed, Bark and Whole Pod of Okra (Abelmoschus esculentus (L.) Moench): A Comparative Study

“…However, for the αglucosidase inhibitory activity, the whole pod extract (IC50 = 0.04 mg/mL) showed a more potent α-glucosidase inhibitory effect than extract of the seed (IC50 = 0.07 mg/mL) as well as the bark (IC50 = 0.09 mg/mL). The inhibition of carbohydrate metabolizing enzyme by different parts of okra pod correlates with the investigation conducted by Abbas et al, 41 which demonstrated the antihyperglycemic effect of dehydrated okra fruits on alloxan-induced diabetic rats. These effects were attributed to oxidative stress reduction and improved antioxidant capacity.…”

Comprehensive Overview of the Effects of Amaranthus and Abelmoschus esculentus on Markers of Oxidative Stress in Diabetes Mellitus

“…However, due to reduced CAT activity, beta cells of the pancreas that contain many mitochondria undergo oxidative stress by producing excess ROS that leads to β-cells dysfunction and, ultimately, diabetes [ 18 ]. Interestingly, evidence presented in Table 2 showed that Abelmoschus esculentus treatment in rodent models of diabetes significantly increases CAT activity [ 91 , 95 , 105 , 106 , 113 , 115 , 117 ]. This suggests that Abelmoschus esculentus may ameliorate oxidative stress, further reduce complications of DM, or prevent DM in non-diabetics ( Figure 4 ).…”

“…It is assumed that the reduction of these markers can substantially alleviate oxidative stress and associated complications. Interestingly, preclinical evidence gathered in Table 2 showed Abelmoschus esculentus promising potential in reducing MDA amongst rodent models of DM [ 91 , 95 , 105 , 106 , 113 , 115 , 117 ]. Disappointingly, evidence from a preclinical model of GDM reported by Tian [ 113 ] showed different findings, which suggest the limitation of Abelmoschus esculentus in alleviating oxidative stress in GDM.…”