Antioxidant defenses and immune responses of flounder Paralichthys olivaceus larvae under methylmercury exposure

Ren, Zhonghua; Lü, Jinhu; Huang, Wei; Cao, Liang; Cui, Wenting; Dou, Shuping

doi:10.1016/j.cbpc.2019.108589

Cited by 16 publications

(4 citation statements)

References 51 publications

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“…weaken immune system of marine fish species (Guardiola et al, 2016;Ren et al, 2019). In addition an increase of parasite load in highly contaminated fish was also observed in other studies (Sagerup et al, 2009;Sures and Knopf, 2012).…”

Section: Relationship Between Fish Contamination and Degree Of Infectionsupporting

confidence: 74%

Differential micropollutants bioaccumulation in European hake and their parasites Anisakis sp.

Mille

Soulier

Caill-Milly

et al. 2020

Environmental Pollution

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Organisms are exposed to various stressors including parasites and micropollutants. Their combined effects are hard to predict. This study assessed the trophic relationship, micropollutants bioaccumulation and infection degree in a host-parasite couple. Carbon and nitrogen isotopic ratios were determined in hake Merluccius merluccius muscle and in its parasite Anisakis sp.. Concentrations of both priority (mercury species and polychlorinated biphenyls congeners) and emerging (musks and sunscreens) micropollutants were also measured for the parasite and its host, to detect potential transfer of contaminants between the two species. The results showed partial trophic interaction between the parasite and its host, in accordance with the Anisakis sp. life encysted in hake viscera cavity. PCB transfer between the two species may result from some lipids uptake by the parasite, while no relation occurred for the two other contaminants. Finally, a positive correlation was found between the number of Anisakis sp. larvae and the methylmercury contamination for hake, emphasizing the assumption that the contamination level in methylmercury can weaken immune system of the host enough to affect parasite infection degree.Please note that this is an author-produced PDF of an article accepted for publication following peer review. The definitive publisher-authenticated version is available on the publisher Web site.

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Section: Relationship Between Fish Contamination and Degree Of Infectionsupporting

confidence: 74%

Differential micropollutants bioaccumulation in European hake and their parasites Anisakis sp.

Mille

Soulier

Caill-Milly

et al. 2020

Environmental Pollution

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“…Awasthi and Ratn et al (2018) showed that, chronic exposure to Cr 6+ at 5% and 10% of the 96 h-LC 50 resulted in the upregulation of sod and cat genes, increasing SOD and CAT activities and eliminating high levels of ROS. Ren et al (2019) found that the transcription of cat, gpx, and gr was upregulated in flounder larvae at 10.0 mg/L MeHg and confirmed that such gene transcriptional up-regulation usually occurred in parallel with the enhancement of the corresponding antioxidants. Similarly, in the current study, we observed that the expression levels of antioxidant-related genes in grouper increased on days 10 and 20 of Mn 2+ exposure at 1, 2, and 4 mg/L, but decreased at 30 d with respect to sod and cat in the 4 mg/L group and gpx and gr in the 2 and 4 mg/L groups.…”

Section: Discussionmentioning

confidence: 52%

Effect of long-term manganese exposure on oxidative stress, liver damage and apoptosis in grouper Epinephelus moara ♀ × Epinephelus lanceolatus ♂

et al. 2022

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Manganese is an indispensable trace element, however, it may be present at high concentrations in water and sediments of aquatic ecosystems due to natural and anthropogenic activities, and can interfere with physiological and biochemical mechanisms in fish. This study was conducted to determine the toxic effects associated with exposure to Mn2+ (0, 0.5, 1, 2, and 4 mg/L) for 30 d, regarding liver damage and apoptosis in Yunlong grouper (Epinephelus moara♀×E. lanceolatus♂). Expression of superoxide dismutase (sod) and catalase (cat) genes in the liver was significantly increased on days 10 and 20 following Mn2+ exposure (4 mg/L), but was reduced on day 30. Similarly, expression of glutathione peroxidase (gpx) and glutathione reductase (gr) genes was elevated after 10 d of exposure to 2 and 4 mg/L Mn2+, but decreased after 20 and 30 d. After 30 d of exposure to high concentrations (2 and 4 mg/L) of Mn2+, liver tissue showed hepatic sinusoidal gap congestion, dilatation, cell vacuolation, and necrosis. In addition, the activities of alanine aminotransferase (ALT) and aspartate transaminase (AST) as well as 8-hydroxydeoxyguanosine (8-OHdG) levels were significantly increased after Mn2+ exposure. Moreover, Mn2+ exposure altered the expression pattern of some pivotal genes associated to apoptosis (p53, bax, bcl-2, apaf-1, caspase-9, and caspase-3), which suggested that Mn2+ exposure induces apoptosis through the mitochondrial pathway. The above results showed that excessive Mn2+ induced apoptosis and liver damage in grouper through elicitation of oxidative stress. These insights help elucidate the mechanism by which Mn2+ induces toxicity in marine fish, and provide a new perspective regarding the detrimental effects of heavy metals in fish.

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“…Metal exposure in fish also acts as a potent antigen and can lead to the unwarranted suppression or stimulation of plasma Ig-M levels [70]. Ren et al [71] reported significant decrease in plasma Ig-M levels in P. olivaceus upon methylmercury exposure and they suggested that apoptosis of B lymphocytes induced by methylmercury toxicity may have been responsible for this decrease. In contrast, exposure to certain metals, such as arsenic and lead induces significant increases in plasma Ig-M levels in S. schlegelii, which is believed to represent an immune stimulus for metal detoxification, as metals are recognized as a foreign substance [27,59].…”

Section: Discussionmentioning

confidence: 99%

Toxic Effects on Oxidative Stress, Neurotoxicity, Stress, and Immune Responses in Juvenile Olive Flounder, Paralichthys olivaceus, Exposed to Waterborne Hexavalent Chromium

Lee

Kim

Lee

et al. 2022

Biology

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Juvenile Paralichthys olivaceus were exposed to waterborne hexavalent chromium at various concentrations (0, 0.5, 1.0, and 2.0 mg/L) for 10 days. After chromium exposure, the activities of superoxide dismutase and glutathione S-transferase, which are oxidative stress indicators, were significantly increased; however, the glutathione level was significantly reduced. Acetylcholinesterase activity as a neurotoxicity marker was significantly inhibited upon chromium exposure. Other stress indicators, including plasma cortisol and heat shock protein 70, were significantly increased. The immune response markers (lysozyme and immunoglobulin M) were significantly decreased after chromium exposure. These results suggest that exposure to environmental toxicity in the form of waterborne chromium at concentrations higher than 1.0 mg/L causes significant alterations in antioxidant responses, neurotransmitters, stress, and immune responses in juvenile olive flounders. This study will provide a basis for an accurate assessment of the toxic effects of hexavalent chromium on aquatic organisms.

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Antioxidant defenses and immune responses of flounder Paralichthys olivaceus larvae under methylmercury exposure

Cited by 16 publications

References 51 publications

Differential micropollutants bioaccumulation in European hake and their parasites Anisakis sp.

Differential micropollutants bioaccumulation in European hake and their parasites Anisakis sp.

Effect of long-term manganese exposure on oxidative stress, liver damage and apoptosis in grouper Epinephelus moara ♀ × Epinephelus lanceolatus ♂

Toxic Effects on Oxidative Stress, Neurotoxicity, Stress, and Immune Responses in Juvenile Olive Flounder, Paralichthys olivaceus, Exposed to Waterborne Hexavalent Chromium

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