Antioxidant defence in recurrent abortion

Vural, Pervin; Akgül, Cemil; Yıldırım, Alkan; Canbaz, Mukaddes

doi:10.1016/s0009-8981(99)00255-7

Cited by 77 publications

(49 citation statements)

References 15 publications

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“…It supports an evidence of increased lipid peroxydation [4] [7]. These results also showed that in women who undergo abortion there is an imbalance of redox status with prooxidative activity, and increased oxidative stress may be the cause of abortus [2] [6]. Pregnancy is also associated with some degree of oxidative stress.…”

Section: Discussionsupporting

confidence: 85%

“…The elevated level of IL-4 proves that vitamin C plays a role in immunological pathway of IL-4 which is found in Th1 pathway that maintains pregnancy. Some studies have also proven that vitamin C administration can maintain the humoral and cellular immune responses in vivo and in vitro [6]. The decreased level of IFN-γ, VCAM-1 and DSA RI were also associated with an improvement caused by antioxidant status.…”

Section: Discussionmentioning

confidence: 95%

“…This is related to the role of vitamin C which is a water-soluble antioxidant that has a particularly significant function in the cell membrane and system vascular improvement [2]. Vitamin C also maintains humoral and cellular immune responses in vivo and in vitro [6]. This immunological change also affects the improvement of endothelial damage that is proved by the decreased level of VCAM-1.…”

Section: Discussionmentioning

confidence: 99%

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The Role of Antioxidant Vitamin C on Imminent Abortion through Interaction of Superoxide Dismutase, Interferon-γ, Interleukin-4, Vascular Cells Adhesion Molecule-1, and Decidual Spiral Arteries Blood Flow

Handono¹,

Wirakusumah²,

Mose³

et al. 2015

OJOG

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Imminent abortion needs more serious attention since it remains a big problem in Indonesia considering its epidemiology, morbidity, mortality, and prognosis. In fact, some cases can still be prevented. The objective of this study was to determine pathogenesis, diagnosis, and prognosis of imminent abortion through the role of antioxidant vitamin C in the interaction of superoxide dismutase (SOD), interferon-γ (IFN-γ), interleukin-4 (IL-4), vascular cells adhesion molecule-1 (VCAM-1), and decidual spiral artery resistance index (DSA RI). This study took 10 months from March to December 2007 at Obstetrics and Gynecology Department of Medical Faculty of Padjadjaran University/Hasan Sadikin Hospital, Bandung. Sixty pregnant women who met the inclusion and exclusion criteria were divided into two groups with the random clinical trial method, double-blind with repeated measurements. Data were analyzed statistically using t test, Mann-Whitney, Rank Spearman, Wilcoxon, t paired, and diagnostic test. The results of this study showed that the incidence of abortion in vitamin C group was 9 cases (30%) and placebo group was 13 cases (43.3%).

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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The Role of Antioxidant Vitamin C on Imminent Abortion through Interaction of Superoxide Dismutase, Interferon-γ, Interleukin-4, Vascular Cells Adhesion Molecule-1, and Decidual Spiral Arteries Blood Flow

Handono¹,

Wirakusumah²,

Mose³

et al. 2015

OJOG

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“…Vural et al 28 demonstrated that plasma ascorbic acid (vitamin C) and α-tocopherol (vitamin E) levels were significantly lower in women with recurrent spontaneous abortions. Furthermore, Oyawoye et al have reported the total antioxidant capacity levels to be lower in the case of inferior oocyte and embryo formation.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress Markers in IVF Patients and Their Association with Pregnancy Results

Okyay¹,

Aslan²,

Taşkın³

et al. 2014

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Oxidative stress has been well recognized as a component in the pathogenesis of many diseases, including female infertility. In this study, we aimed to investigate serum paraoxonase (PON1), arylesterase and myeloperoxidase (MPO) activities, and lipid hydroperoxide (LOOH) levels as oxidative stress markers along with their relationship with the pregnancy rate in women undergoing in vitro fertilization (IVF) treatment. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Serum samples of 179 subjects were collected immediately before starting ovarian stimulation and on ovum pick-up (OPU) day during IVF treatment. Stimulation protocol and starting doses were determined individually. When the leading follicle reached at least 17 mm in size, recombinant human chorionic gonadotropin (Ovitrelle, 250 mcg, Serono) was administered for ovulation induction. Serum basal/salt-stimulated paraoxonase, arylesterase activities, myeloperoxidase activity, and lipid hydroperoxide levels were compared between two samples. Subjects were also divided into two groups according to the presence of pregnancy, and the groups were compared in terms of oxidative stress markers studied. R Re es su ul lt ts s: : Serum MPO activity and LOOH levels were significantly higher on ovum pick up day (p<0.05, p<0.001, respectively), while basal/salt-stimulated paraoxonase and arylesterase activities were significantly lower (p=0.012, p=0.041, respectively) than those before ovarian stimulation. Serum LOOH levels on OPU day were significantly higher in non-pregnant group than pregnant one (p<0.001). Although basal/salt-stimulated paraoxonase, arylesterase and myeloperoxidase activities were higher in the non-pregnant group compared to the pregnant group, it was not statistically significant (p>0.05). C Co on nc cl lu us si io on n: : Ovarian stimulation during IVF treatment resulted in increased oxidative stress and decreased PON1 activity. However, changes in the studied parameters were not found to be significantly associated with the pregnancy results. Further studies are required to clarify our results.K Ke ey y W Wo or rd ds s: : In vitro fertilization; lipid peroxides; peroxidase; PON1 protein, human Ö ÖZ ZE ET T A Am ma aç ç: : Oksidatif stresin, kadın infertilitesi de dahil olmak üzere bir çok hastalığın patogenezinde yer aldığı gösterilmiştir. Bu çalışmada, in vitro fertilizasyon (IVF) tedavisi uygulanan kadın-larda oksidatif stres belirteçlerinden serum paraoksonaz (PON1), myeloperoksidaz (MPO), aril esteraz aktiviteleri ile lipid hidroksiperoksid (LOOH) düzeylerini ve bu belirteçlerin gebelik oranlarıyla ilişkisini araştırmayı amaçladık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Yüz yetmiş dokuz olgunun serum örnekleri ovaryan stimulasyona başlanmadan hemen önce ve tedavi esnasında yumurta toplama günü (OPU) alındı. Stimulasyon protokolü ve başlangıç dozları bireysel olarak belirlendi. Dominant folikül boyutu en az 17 mm'ye ulaştığında, ovulasyonu tetiklemek için reko...

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“…Numerous animal and human studies have demonstrated that reactive oxygen species (ROS) were produced in ovaries, fallopian tubes and embryos [1][2][3]. Evidence from recent studies has suggested that ROS plays an essential role in oocyte maturation, formation of corpus luteum and luteolysis, furthermore, ROS is unavoidably associated with adverse reproductive outcome in both female and male [1,[4][5][6][7]. The impact of follicular fluid oxidative stress on oocyte maturation, fertilization and implantation of embryo have received considerable attention for therapeutic measures of ovulation induction for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) during last few years.…”

Section: Introductionmentioning

confidence: 99%

A comparative study on oxidative and antioxidative markers of serum and follicular fluid in GnRH agonist and antagonist cycles

Çelik

Kumbak

et al. 2012

J Assist Reprod Genet

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Objective To determine whether concentrations of oxidative stress markers of follicular fluid and serum are different in GnRH agonist protocol from GnRH antagonist protocol. Material and method This was a cross-sectional study. Eighty-four women undergoing controlled ovarian stimulation with either GnRH agonist (n039) or GnRH antagonist protocols (n045) for IVF/ICSI treatment were assigned by a physician. Blood was obtained at the time of oocyte retrieval, and follicular fluid (FF) from the mature follicles of each ovary was centrifuged and frozen until analysis. Malondialdehyde (MDA), nitric oxide (NO), protein carbonyl (PC), hydroxyl proline (OH-P), sodium oxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), adenosine deaminase (ADA) and xanthine oxidase (XO) were assessed in the serum and follicular fluid of each participants. ResultsThe mean serum concentrations of GSH-Px, GSH and MDA were lower in the GnRH antagonist group compared to GnRH agonist group, but mean serum SOD was higher in the GnRH antagonist group. The mean follicular SOD, ADA and NO were higher in GnRH antagonist group than GnRH agonist group. The IVF/ICSI outcomes were similar in both groups. Conclusion(s) GnRH antagonist protocol is associated with increased oxidative stress. The relation of GnRH analogues with oxidative stress and its implication in follicular growth needs to be addressed in further studies.

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Antioxidant defence in recurrent abortion

Cited by 77 publications

References 15 publications

The Role of Antioxidant Vitamin C on Imminent Abortion through Interaction of Superoxide Dismutase, Interferon-γ, Interleukin-4, Vascular Cells Adhesion Molecule-1, and Decidual Spiral Arteries Blood Flow

The Role of Antioxidant Vitamin C on Imminent Abortion through Interaction of Superoxide Dismutase, Interferon-γ, Interleukin-4, Vascular Cells Adhesion Molecule-1, and Decidual Spiral Arteries Blood Flow

Oxidative Stress Markers in IVF Patients and Their Association with Pregnancy Results

A comparative study on oxidative and antioxidative markers of serum and follicular fluid in GnRH agonist and antagonist cycles

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