Antioxidant compound supplementation prevents oxidative damage in a Drosophila model of Parkinson's disease

Casani, Sandra; Gómez-Pastor, Rocío; Matallana, Emilia; Paricio, Nuria

doi:10.1016/j.freeradbiomed.2013.03.021

Cited by 54 publications

(62 citation statements)

References 61 publications

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“…However, this prooxidant action is mainly found in vitro, and under high concentrations [26,27]. Some in vivo studies have also shown pro-oxidant effects of classical antioxidants, but they are variable depending on substance, concentration, age of the subject and target molecules [25,[28][29][30]. Further, it seems that their preferential action is antioxidant when an oxidant insult from another source is present [31].…”

Section: Discussionmentioning

confidence: 99%

Alpha-Tocopherol Counteracts Cognitive and Motor Deficits Induced by Repeated Treatment with Reserpine

Sarmento-Silva¹,

Lima²,

Cabral³

et al. 2015

Biochem Pharmacol (Los Angel)

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Section: Discussionmentioning

confidence: 99%

Alpha-Tocopherol Counteracts Cognitive and Motor Deficits Induced by Repeated Treatment with Reserpine

Sarmento-Silva¹,

Lima²,

Cabral³

et al. 2015

Biochem Pharmacol (Los Angel)

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“…An in vitro and in vivo study of Parkinsonism showed that antioxidants offered prevention against oxidative neuronal damage [66] . Report by Bahadorani and Hilliker (2008) [129] have showed that in drosophila model of huntington's disease the antioxidants could not offer neuroprotective effects whereas trial of α-tocopherol in HD patients have showed the beneficial effects on antioxidants [130] . Combinative therapy of α-tocopherol with folic acid could mitigate the amyloid β induced neurotoxicity in mice model [131] .…”

Section: Evidences For the Beneficial Use Of Antioxidants In Neurodegmentioning

confidence: 99%

Antioxidants as a preventive therapeutic option for age related neurodegenerative diseases

Singh

2015

Ther Targets Neurol Dis

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Neurodegenerative diseases: an overview -Neurodegenerative disease term illustrate a range of conditions in which primarily neurons get affected or die. Neurons are the building blocks of the central and peripheral nervous system. Neurons could not reproduce or replace themselves with age therefore, when they get damaged or die they cannot be replaced and lead to specific neurodegenerative disease. Few evidences for the presence of stem cells are reported [1] but still it is not understood whether damaged neuron could regenerate or not. The Parkinson's, Alzheimer's, and Huntington's diseases are the most prevalent age related neurodegenerative diseases of central nervous system involving death of specific neuronal population. The treatment of these neurodegenerative diseases might involve the re-supplementation of specific neuronal population with the help of stem cells but researchers and clinicians did not get noticeable success in this approach yet. Millions of people each year are getting affected by these neurodegenerative diseases and the incidences are increasing further significantly with the extended life expectancy. It has been reported by World Health Organisation (2006) that the number of older people of more than 65 years age are expected to increase to approximately 1 billion in 2030 worldwide. Developing countries like India and China will see the largest increase in numbers of aged persons. Therefore the percentage of aged population in developing countries would increase from 59% to 71% worldwide [2] . Since occurrence of most of the neurodegenerative Advances in our understanding for neurodegenerative mechanisms have increased significantly in last few decades. But still no novel disease modifying therapy has been developed which could prevent the disease progression and drawn our attention towards the development of new alternative therapy. The major obstacle for the development of disease therapy is incomplete knowledge about neurodegenerative mechanisms. Due to the insufficient information about neurodegenerative mechanisms no standard diagnostic tests for the detection of neurodegenerative disease could be develop to date, causes delayed diagnosis and disease worsening. So far the exploratory reports and clinical data have suggested the involvement of oxidative stress, mitochondrial impairment and apoptosis as major neurodegenerative mechanisms. Investigations have elicited that once initiated the degeneration of neurons could not be arrested therefore in the scarcity of curative therapy we should approach for the preventive neurodegenerative therapy. Since oxidative stress has noteworthy involvement in neuronal death solely, and in connection to other death pathways therefore, antioxidants as preventive therapeutics might provide beneficial effects in age related neurodegenerative diseases. With this hypothesis in this review we are discussing about the use of antioxidants as a preventive treatment of neurodegenerative diseases. Such therapies may work in the preventive phase or in curati...

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“…Citrate is also known to play a vital role in maintenance of normal brain function as a neurotransmitter precursor and in energy production [6,8]. It is well studied that supplementation of antioxidant compound protects cells against the damaging effect of Reactive Oxygen Species (ROS) [9]. Antioxidant compounds such as vitamin C, E, carotenoids and several polyphenolic compounds used as dietary supplements have ability to scavenge the oxygen free radicals and save the cells from any damage i.e.…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation of Citric acid (monohydrate) Improves Health Span in Drosophila melanogaster

2016

J App Biol Biotech

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Citric acid is a biochemical compound present in variety of citrus fruits. Citrate plays a vital role in production of energy (ATP) via Tricarboxylic acid (TCA) cycle and also involve in Fatty acid (FA) synthesis in cytoplasm. The objective of this study is to evaluate the effect of citric acid supplementation on health span in Drosophila melanogaster. OregonR + fly used in most of the experiments. Body weight of male and female flies fed on normal and citric acid mixed diet was determined, locomotor assay and anti-oxidant activity associated with citric acid was measured by performing superoxide dismutase (SOD) and catalase (CAT) enzymatic assay. Fat content in citric acid fed flies was evaluated by Oil Red O staining in fat body tissues of adult Drosophila. Reverse trascriptase PCR (RT-PCR) analysis was performed to check the expression level of Brummer (bmm) and Fatty acid Synthase (FAS) genes. In the present study we have shown that supplementation of citric acid reduces body weight of male and female flies, improves locomotor activity of Alzheimeric flies, reduces oxidative stress and increases FA synthesis in Drosophila. Here, we concluded that supplementation of citric acid (monohydrate) improves health span in Drosophila.

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Antioxidant compound supplementation prevents oxidative damage in a Drosophila model of Parkinson's disease

Cited by 54 publications

References 61 publications

Alpha-Tocopherol Counteracts Cognitive and Motor Deficits Induced by Repeated Treatment with Reserpine

Alpha-Tocopherol Counteracts Cognitive and Motor Deficits Induced by Repeated Treatment with Reserpine

Antioxidants as a preventive therapeutic option for age related neurodegenerative diseases

Dietary Supplementation of Citric acid (monohydrate) Improves Health Span in Drosophila melanogaster

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