Antioxidant capacity of erythrocytes from sheep chronically poisoned by copper

Sansinanea, Aldo; Cerone, Silvia; Quiroga, Miguel; Auza, N.

doi:10.1016/s0271-5317(05)80592-5

Cited by 9 publications

(12 citation statements)

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“…Our previous studies on the biochemical mechanisms of hemolytis in copper overload suggested that two factors produced oxidative damage in the RBC: 1) copper-induced production of free radicals and 2) decreased antioxidant capacity [12]. In this study we found, from the beginning of the 13th week until the end of the experiment, elevated serum copper levels and increased lipid peroxide levels in the membranes from the loaded sheep, which suggested copper-induced peroxidation.…”

Section: Discussionsupporting

confidence: 63%

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The Effect of Copper Overload on the Sheep Erythrocyte Membrane.

Sansinanea¹,

Cerone²,

Catalá³

et al. 1996

J. Clin. Biochem. Nutr.

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SummaryThe effect of copper overload on the red blood cell (RBC) membrane from experimentally copper-poisoned sheep was evaluated by studying the lipid peroxidation, composition of fatty acids, and protein organization of RBC membranes. Ten ewes were dosed orally with CuS44 in order to induce copper toxicity. The level of lipid peroxidation products was examined in RBC ghosts by measuring their thiobarbituric acid reactivity. The measurement of fatty acids was accomplished by gas-liquid chromatography; and the study of membrane proteins, by SDS-PAGE. The results showed increased lipid peroxidation levels and reduced content of 18:1, 18:2, and 18:3 fatty acids in RBC from copperpoisoned sheep. Despite the RBC copper-overload, treated sheep showed a qualitatively normal protein pattern, but the amount of band 3 of membrane proteins increased. We established a relationship between copper overload and alterations in the RBC membrane structure.

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Section: Discussionsupporting

confidence: 63%

“…A decrease in total phospholipids in the erythrocyte membranes was observed in blood samples from animals that had ingested large amounts of copper [5]. It has been suggested that peroxidative damage can play an important role in the development of hemolysis [12].…”

mentioning

confidence: 99%

The Effect of Copper Overload on the Sheep Erythrocyte Membrane.

Sansinanea¹,

Cerone²,

Catalá³

et al. 1996

J. Clin. Biochem. Nutr.

Self Cite

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“…A ovinocultura tem se expandido nesta última década nas regiões Sul, (SANSINANEA et al,1993;ORTOLANI, 2002).…”

Section: Introdução E Revisão De Literaturaunclassified

“…Entre as espécies de animais domésticos os ovinos são, sem qualquer dúvida, os mais sujeitos a apresentarem tanto deficiência como quadro de intoxicação pelo cobre (GOONERATNER et al, 1981;SANSINANEA et al, 1993).…”

Section: Introdução E Revisão De Literaturaunclassified

“…Embora vários trabalhos tenham indicado ultraestruturalmente ou bioquimicamente o comprometimento renal no caso da intoxicação (GOONERATNE et al, 1986;HOWELL e GOONERATNE, 1987;SANSINANEA et al 1993;ORTOLANI e MACHADO, 2002a), faltam estudos que demonstrem a relação entre a intensidade da intoxicação cúprica e o grau de funcionalidade dos rins, em especial no concernente a filtração glomerular e função tubular, que atestem e quantifiquem a insuficiência renal.…”

Section: Introdução E Revisão De Literaturaunclassified

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Efeitos da intoxicação cúprica e do tratamento com tetratiomolibdato sobre a função renal e o metabolismo oxidativo de ovinos

Soares¹

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Copper and Zinc Nutritional Issues for Agricultural Animal Production

Hill

Shannon

2019

Biol Trace Elem Res

109

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Livestock have presented unique requirements and toxicity issues depending on the species for the various concentrations of Cu and Zn and their interactions with other nutrients especially Fe, Se, Mo, and S. Soil concentrations of these elements and their availability to crops influence the health of the crop and the amount found in vegetative tissues and seeds. Hence, many livestock issues are a result of the soils in the area where production is occurring (Loneragan et al. 1981 ). While water can provide minerals to animals, the amount consumed and availability are highly variable. Many discoveries about Cu were a result of low Cu concentrations and its availability due to interactions with other nutrients in the soils. Anemia, bone disorders, cardiovascular abnormalities, defective wool and hair, and infertility are signs/symptoms of Cu deficiency. Toxicity due to excess Cu is more likely to occur in sheep than other farm species. Swine are tolerant of high concentrations of dietary Cu, and it is often used as a growth stimulant in production. There are many species and physiological stages where the animal’s Cu requirement is not known. Grazing animals can exhibit Zn deficiency when soils and forages contain limited concentrations of Zn. Pastures have been observed to be Zn-deficient in many parts of the world. However, non-ruminant animals usually receive adequate Zn when fed corn and soybean meal diets if there is not excessive Ca and Fe in their diets, but this is not true for rapidly growing young animals. Characteristics of a Zn deficiency include loss of appetite, reduced growth and reproduction, and impaired health of bone and skin tissues.

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Antioxidant capacity of erythrocytes from sheep chronically poisoned by copper

Cited by 9 publications

References 11 publications

The Effect of Copper Overload on the Sheep Erythrocyte Membrane.

The Effect of Copper Overload on the Sheep Erythrocyte Membrane.

Efeitos da intoxicação cúprica e do tratamento com tetratiomolibdato sobre a função renal e o metabolismo oxidativo de ovinos

Copper and Zinc Nutritional Issues for Agricultural Animal Production

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