Antioxidant antileishmanial cytotoxic and antimicrobial activities of a local plant  Myrtus nivellei  from Algeria Sahara

Ramdane, Farah; Farès, Nadia; Ouassis, Dahmane El; Aziz, Sana; Mahammed, Mahfoud Hadj; Hadj, Mohamed Didi Ould El; Limam, Férid

doi:10.1016/j.apjtb.2017.07.011

Cited by 10 publications

(7 citation statements)

References 24 publications

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“…These compounds or secondary metabolites particularly possess also anti-protozoan activities, especially against Plasmodium, Leishmania and Trypanosoma spp. [46][47][48][49][50]. Then, the phenolic compounds are good candidate molecules due to a relatively low or no toxicity and because the presence of some flavonoids limits the resistance of protozoan to other drugs [51].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Anticoccidial Activity of Olive Pulp (Olea europaea L. var. Chemlal) Extract Against Eimeria Oocysts in Broiler Chickens

et al. 2019

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Aim The objective of the present study was to investigate in vitro anticoccidial effect of olive pulp (Olea europaea L var. Chemlal) extract on the destruction of Eimeria spp. oocysts isolated from infected chickens naturally. Materials and methods The olive pulp (OP) powder was stirred manually in aqueous ethanol in preparation for extraction using the microwave-assisted extraction system. The identification of the phenolic compounds was obtained by ultra-highperformance liquid chromatography-mass spectrometry with electrospray ionisation (HPLC-ESI-MS). The treatment of Eimeria oocyst with OP extract and standard compounds (quercetin and oleuropein) leads to their lysis as shown by the release of substances absorbing at 273 nm. Results Our results showed that the maximum number of reduced oocysts was recorded after 8 h of incubation of optimum OP extract, quercetin and oleuropein for different periods of time. Also, the number of Eimeria oocysts decreased considerably with increase concentrations after adding the optimum of OP extract in concentration ranging from 0.023 to 0.371 mg/ ml. Positive correlation between the optimum OP extract concentrations and the number of Eimeria oocysts reduced was R 2 = 0.959. From this in vitro experiment, it can be concluded that the OP extract possesses an anti-Eimeria spp activity. Conclusion To our knowledge, this is the first time that quercetin and oleuropein were tested to evaluate their anticoccidial activity. The findings of this study showed that phenolic compound of OP extract tested separately possesses anti-Eimeria spp. effect. Further studies should be carried out to test its in vivo efficacy of the OP bioactive compounds in broiler chickens.

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Section: Discussionmentioning

confidence: 99%

In Vitro Anticoccidial Activity of Olive Pulp (Olea europaea L. var. Chemlal) Extract Against Eimeria Oocysts in Broiler Chickens

et al. 2019

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“…Studies on the extract of M. nivellei leaves indicated that the hydromethanolic, ethyl acetate, butanolic and aqueous fraction had the highest values in phenolic content (222.98 ± 4.70, 308.4 ± 7.40, 414.96 ± 2.40 and 128.03 ± 1.87 mg GAE/g DS, respectively) (Ramdane et al, 2017). In another study on the aqueous extract of the leaves of M. nivellei, the level of total polyphenols was estimated around 242.68 ± 9.79 mg GAE/g DS (Rached et al, 2010).…”

Section: Total Polyphenols Contentmentioning

confidence: 99%

“…They found that the best activity was reported for the ethyl acetate and n-butanol fractions with IC50 values of 3.08 ± 0.40 μg/mL and 4.40 ± 0.43 μg/mL, respectively. In addition, Ramdane et al (2017) reported IC50 values between 4.97 μg/mL and 16.33 μg/mL, for the different extracts obtained from M. nivellei leaves (hyudromethanol, ethyl acetate, butanolic and aqueous).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Polyphenols Content and Antimicrobial, Antioxidant and Hemolytic Activities of Essential Oils from Four Selected Medicinal Plants Growing in Algeria

et al. 2020

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The Saharan and steppe spontaneous plants are very characteristic because of their particular adaptation to the desert and extreme environment. Some species have pharmacological properties that give them a medicinal interest. The aim of the present work was to determine the polyphenol contents of essential oils obtained from four endemic plants growing in Algeria (Pituranthos scoparius, Myrtus nivellei, Rosmarinus officinalis and Mentha piperita), and study its biological activity, including antimicrobial, antioxidant, and hemolytic. The antimicrobial activity was evaluated by the microdilution method against twelve strains. The antioxidant activity was carried out by two methods (DPPH radical scavenging and reducing power). However, the hemolytic effect has been evaluated against the red blood cells. P. scoparius and M. piperita showed yields of essential oils higher than 1%. All the strains showed sensitivity against the essential oils tested with the exception of the C. albicans treated by R. officinalis essential oils. The most sensitive strain was C. albicans treated by P. scoparius essential oils by MIC of 0.0781 mg/mL, it was the same plant that shows the highest polyphenol content (14.78 ± 0.72 g GAE/g DS). The antioxidant activity by the DPPH method was greater for all essential oils tested by IC50 ranging from 0.69 ± 0.07 (R. officinalis) to 30.67 ± 2.12 mg/mL (M. nivellei). The R. officinalis essential oils reported more antioxidant power than the positive control (ascorbic acid). In reducing iron, it was the R. officinalis essential oils which were found to be the most active with an EC50 concentration of 9.67 ± 1.36 mg/mL. After 120 min incubation, minimal haemolysis (10%) was obtained with essential oils of R. officinalis at a concentration of 0.39 mg/mL. We conclude that P. scoparius essential oils showed the high content of polyphenols and R. officinalis essential oils reported more antioxidant power than the positive control (ascorbic acid).

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“…& Trab. is a one the most aromatic species used in popular culture medicine for treatment of many diseases in south part of Algeria (7,8). Previous biological and pharmacological investigations on Sahara myrtle were connected its efficiency to the presence of effective phytochemicals including phenolic and volatile compounds (7,8,9,10,11).…”

Section: Introductionmentioning

confidence: 99%

“…is a one the most aromatic species used in popular culture medicine for treatment of many diseases in south part of Algeria (7,8). Previous biological and pharmacological investigations on Sahara myrtle were connected its efficiency to the presence of effective phytochemicals including phenolic and volatile compounds (7,8,9,10,11). These latter are evenly characterized largely aromatic species (12,13) to gather with phenolic compounds (14,15); which can play important roles in health care as antioxidant (15,16) and as antimicrobial agents (17).…”

Section: Introductionmentioning

confidence: 99%

Essential oil and ethanolic extract composition from Myrtus nivellei Batt. & Trab. and their biological evaluations

Ramdane

Medjour²,

Ben³

et al. 2021

ACTA PERIOD TECHN

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This study aims to evaluate the chemical composition and biological effects of an endemic Algerian species Myrtus nivellei belonging to the Myrtaceae family. The aerial parts of the plant were submitted to hydrodistillation and analysed with gas chromatography - mass spectrometry (GC-MS). This oil was yielded 0,75% (w/w). The GC-MS revealed that 1,8 cineole is the most abundant component (53,44%) while other compounds were present in high contents: 2,2,6,7-tetramethyl-10-oxatricyclo [4.3.0.1(1,7)]- decan-5-one (11,73%), trans ocimene (7,54%), linalyl propirionate (6,81%) and lavandulyl acetate (5,24%). In addition ethanolic extract of studied plant was prepared. Total phenol, tannin, flavonoid, and condensed tannin?s contents were determined using Folin-Ciocalteu, aluminum chloride and vanillin colorimetric methods, respectively. Three tests were used for the investigation of antioxidant activity of both extract and oil. Strong antioxidant activity was shown mainly by crude extract. Antibacterial screening was evaluated against Gram positive and Gram negative bacteria. Ethanolic extract and oil were active especially against Staphylococcus aureus.

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Antioxidant antileishmanial cytotoxic and antimicrobial activities of a local plant Myrtus nivellei from Algeria Sahara

Cited by 10 publications

References 24 publications

In Vitro Anticoccidial Activity of Olive Pulp (Olea europaea L. var. Chemlal) Extract Against Eimeria Oocysts in Broiler Chickens

In Vitro Anticoccidial Activity of Olive Pulp (Olea europaea L. var. Chemlal) Extract Against Eimeria Oocysts in Broiler Chickens

Polyphenols Content and Antimicrobial, Antioxidant and Hemolytic Activities of Essential Oils from Four Selected Medicinal Plants Growing in Algeria

Essential oil and ethanolic extract composition from Myrtus nivellei Batt. & Trab. and their biological evaluations

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