Antioxidant, anti-inflammatory and neuroprotective effect of kaempferol on rotenone-induced Parkinson’s disease model of rats and SH-S5Y5 cells by preventing loss of tyrosine hydroxylase

Pan, Xiaohua; Liu, Xiuzhen; Zhao, Hai; Wu, Bo; Liu, Guorong

doi:10.1016/j.jff.2020.104140

Cited by 51 publications

(19 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is considered as a safe and efficient anti-inflammatory agent, although caution is required as some in vitro studies have demonstrated its carcinogenic and toxic properties [279,280]. Regarding its neuroprotective potential, it protected PC12 cells from the toxic effects of Aβ [281], and SH-SY5Y cells and primary neurons from rotenoneinduced toxicity [168,282]. In PC12 cells, kaempferol also attenuated HNE-induced activation of the JNK pathway and apoptotic events by directly inhibiting NADPH oxidase [283].…”

Section: Kaempferolmentioning

confidence: 99%

“…Similar neuroprotective effects of kaempferol were demonstrated in a rotenone-induced rat model of PD. Besides its anti-oxidative and anti-apoptotic effects, preservation of tyrosine hydroxylase activity and improvement in dopamine levels and behavioral deficits, kaempferol inhibited the production of pro-inflammatory cytokines IL-6 and TNF-α, suggesting that its neuroprotective ability relies, at least partially, on the NF-κB pathway [282].…”

Section: Kaempferolmentioning

confidence: 99%

See 1 more Smart Citation

Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration

et al. 2021

View full text Add to dashboard Cite

Neurodegenerative diseases are one of the leading causes of disability and death worldwide. Intracellular transduction pathways that end in the activation of specific transcription factors are highly implicated in the onset and progression of pathological changes related to neurodegeneration, of which those related to oxidative stress (OS) and neuroinflammation are particularly important. Here, we provide a brief overview of the key concepts related to OS- and neuroinflammation-mediated neuropathological changes in neurodegeneration, together with the role of transcription factors nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-κB (NF-κB). This review is focused on the transcription factor p53 that coordinates the cellular response to diverse genotoxic stimuli, determining neuronal death or survival. As current pharmacological options in the treatment of neurodegenerative disease are only symptomatic, many research efforts are aimed at uncovering efficient disease-modifying agents. Natural polyphenolic compounds demonstrate powerful anti-oxidative, anti-inflammatory and anti-apoptotic effects, partially acting as modulators of signaling pathways. Herein, we review the current understanding of the therapeutic potential and limitations of flavonols in neuroprotection, with emphasis on their anti-oxidative, anti-inflammatory and anti-apoptotic effects along the Nrf2, NF-κB and p53 pathways. A better understanding of cellular and molecular mechanisms of their action may pave the way toward new treatments.

show abstract

Section: Kaempferolmentioning

confidence: 99%

Section: Kaempferolmentioning

confidence: 99%

Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration

et al. 2021

View full text Add to dashboard Cite

show abstract

“…These compounds originate from the secondary metabolism of plants and are responsible for providing bioactive and beneficial properties to the human organism (Melo et al, 2021). Kaempferol stood out in the MGF composition; its activities are related to anticancer (mainly colon and skin), anti‐inflammatory, neuroprotective, immunomodulatory, cardiovascular, antioxidant, and antidiabetic effects, studied in the health, chemistry, and pharmaceutical areas (Molitorisova et al, 2021; Pan et al, 2020). Similar to kaempferol, catechin is also a flavonoid that stood out in the MGF composition.…”

Section: Resultsmentioning

confidence: 99%

Study of mesquite grain flour ( Prosopis juliflora Sw. DC ) in hamburger storage

Cavalcante

Melo

Almeida

et al. 2022

Food Processing Preservation

View full text Add to dashboard Cite

Prosopis juliflora grain is considered a by‐product few used in human food. Thus, the objective of this article was to evaluate the use of mesquite grain flour (MGF) in beef hamburgers and assess their physicochemical, antioxidant, and technological properties during 60 days of storage at −18°C. The hamburgers showed high protein content and there was a significant effect (p < .05) between the use of MGF and the storage, analyzed by physicochemical properties. Even though the MGF used in the hamburgers acted as a pro‐oxidant in lipid oxidation, they also acted as an antioxidant in the oxidation of the proteins. In the texture profile, the hardness, chewiness, and adhesiveness variables varied according to the percentage of MGF added. The best results were obtained at 30 days with the addition of 2 and 4% of MGF, showing the mesquite grain’s potential to be used as a flour for formulation of meat products. Practical applications The mesquite grain flour has high proteins content and bioactive potential thus shows important application possibilities. The flour can produce a hamburger with technological properties (for example, diameter shrinkage good, hardness, adhesiveness, chewability, elasticity, cohesiveness, stiffness, and resilience), bioactive compounds, and high protein content properties, important characteristics for the food industry. This study shows the potential of MGF, which can be inserted to increase the shelf life of a hamburger.

show abstract

“…Moreover, neurotransmitters are an important factor in lactation homeostasis, acting on mammary epithelial cells through an autocrine-paracrine mechanism to influence lactation and milk composition [34]. There are several compounds in HCE that have a modulating effect on neurotransmitters, including those in [35][36][37], which might indirectly regulate lactation. Thus, we speculated that the facilitation of the daylily on lactation is not only due to the effect of a single compound, but also the result of the interaction between several compounds.…”

Section: Discussionmentioning

confidence: 99%

Study and Experimental Validation of the Functional Components and Mechanisms of Hemerocallis citrina Baroni in the Treatment of Lactation Deficiency

Zhong

Liang

Chen

et al. 2021

Foods

View full text Add to dashboard Cite

The function of Hemerocallis citrina Baroni (daylily) on promoting lactation is reported in several ancient Chinese medicine books. However, nowadays, there is no conclusive data to support this statement. In this study, we investigated the effect of Hemerocallis citrina Baroni extract (HCE) on lactation insufficiency in chronic unpredictable mild stress (CUMS) dams and further explored the mechanism and functional components through network pharmacology. The results showed that HCE could increase the offspring’s weight, serum prolactin (PRL), and oxytocin (OT) level of CUMS dams. Network pharmacology analysis revealed that the facilitation of HCE on lactation is the result of the comprehensive action of 62 components on 209 targets and 260 pathways, among this network, quercetin, kaempferol, thymidine, etc., were the vital material basis, signal transducer and activator of transcription 3 (STAT3), mitogen activity protein kinase 1 (MAPK1), tumor protein P53 (TP53), etc., were the core targets, and the prolactin signaling pathway was the core pathway. In addition, verification test results showed that HCE regulated the abnormal expression of the prolactin signaling pathway, including STAT3, cyclin D1 (CCND1), MAPK1, MAPK8, nuclear factor NF-kappa-B p105 subunit (NFKB1), and tyrosine-protein kinase (JAK2). In conclusion, HCE exhibited a facilitation of lactation insufficiency, in which quercetin, kaempferol, thymidine, etc., were the most important material basis. The mechanism of this promotional effect is mediated by the prolactin signaling pathway in mammary gland.

show abstract

Antioxidant, anti-inflammatory and neuroprotective effect of kaempferol on rotenone-induced Parkinson’s disease model of rats and SH-S5Y5 cells by preventing loss of tyrosine hydroxylase

Cited by 51 publications

References 41 publications

Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration

Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration

Study of mesquite grain flour ( Prosopis juliflora Sw. DC ) in hamburger storage

Study and Experimental Validation of the Functional Components and Mechanisms of Hemerocallis citrina Baroni in the Treatment of Lactation Deficiency

Contact Info

Product

Resources

About