Antioxidant, Anti-Inflammatory and Cytotoxic Activity of Phenolic Compound Family Extracted from Raspberries (Rubus idaeus): A General Review

Abstract

Raspberries (Rubus idaeus) possess a wide phenolic family profile; this serves the role of self-protection for the plant. Interest in these compounds have significantly increased, since they have been classified as nutraceuticals due to the positive health effects provided to consumers. Extensive chemical, in vitro and in vivo studies have been performed to prove and validate these benefits and their possible applications as an aid when treating several chronic degenerative diseases, characterized by oxidative stress and an inflammatory response. While many diseases could be co-adjuvanted by the intake of these phenolic compounds, this review will mainly discuss their effects on cancer. Anthocyanins and ellagitannins are known to provide a major antioxidant capacity in raspberries. The aim of this review is to summarize the current knowledge concerning the phenolic compound family of raspberries, and topics discussed include their characterization, biosynthesis, bioavailability, cytotoxicity, antioxidant and anti-inflammatory activities.

Phytochemicals Determination, and Antioxidant, Antimicrobial, Anti-Inflammatory and Anticancer Activities of Blackberry Fruits

“…However, it is not only anthocyanins of blackberry extract that may exert anti-inflammatory activity. Other phenolic compounds and terpenoids have also demonstrated their potential in the inhibition of the inflammation process and the secretion of pro-inflammatory cytokines [ 17 , 75 , 76 ]. Therefore it might be possible that the anti-inflammatory activity demonstrated by blackberry extract was the result of the synergistic effects of various phytochemicals naturally present in blackberry fruits.…”

Phytochemical Profiles, Antioxidant, Cytotoxic, and Anti-Inflammatory Activities of Traditional Medicinal Plants: Centaurea pichleri subsp. pichleri, Conyza canadensis, and Jasminum fruticans

“…To cope with the oxidative stress created by ROS and RNS, antioxidant defenses need to be strong. Phenolic compounds are known to have antioxidant and anti-inflammatory capacities and many studies have shown that phenolic compounds have a scavenging effect on free radicals [ 25 , 26 ]. In addition, they have been extensively studied in recent years, as they exhibit a wide variety of physiological properties such as anti-mutagenic, anti-carcinogenic, and antimicrobial activity [ 27 , 28 , 29 ].…”

Influence of Altitudes and Development Stages on the Chemical Composition, Antioxidant, and Antimicrobial Capacity of the Wild Andean Blueberry (Vaccinium floribundum Kunth)

“…Previous studies have shown that the concentration of polyphenols can increase in response to oxidative stress caused by various factors, such as pests, diseases, ultraviolet light, low temperatures, soil nutrients, and drought [ 83 , 84 ]. Our results for antioxidant capacity are consistent with those and other studies conducted on the same berries species collected in the Ecuadorian Andean region [ 4 , 54 ].…”