Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats

Abstract

Doxorubicin (DOX) is a well-known chemotherapeutic drug for most malgnencies including breast cancer and leukemia whilst the usage of DOX is limited owing to its cardiotoxicity. The present study analyzed the effects of crocin on doxorubicin's cardiotoxic efect in rat myocardium and searched their mechanistic interaction in the pathogenesis of DOX-induced myocardial toxicity. Forty rats were divided into four groups; (a) control (received normal saline as a dose of 1 ml/kg by ip for 15 days), (b) Crocin (received crocin as a dose of 40 mg/kg/24h by ip for 15 days), (c) DOX (received DOX as a dose of 2 mg/kg/48h by ip in six injection, cumulative dose 12 mg/kg), and (d) DOX + Crocin (received DOX as a dose of 2 mg/kg/48h by ip in six injection and crocin as a dose of 40 mg/kg/24h ip for 15 days). According to the present study, DOX administration caused signi cant increases in lipid indices (triglyseride, low-dencity lipoproteins and very low-dencity lipoproteins) as well as cardiac markers (Creatine kinase-muscle/brain and Cardiac Troponin I). Morever, DOX caused signi cant increases in oxidative stress parameters (malondialdehyde and total oxidant status) as well as decreases in antioxidant defense systems (glutathione, superoxide dismutase, catalase and total antioxidant status). The present study also demonstrated that co-administration of crocin with DOX signi cantly ameliorated the lipid pro le and biochemical parameters in rats receiving DOX. The results were supported by histopathological and immunohistochemical evaluations. Taken together, our results reveal that crocin might be a cardioprotective agent in DOX treated patients for cancer.

Effect of Theobroma cacao L. on the Efficacy and Toxicity of Doxorubicin in Mice Bearing Ehrlich Ascites Carcinoma

“…Cocoa ameliorates the lipid profile in dyslipidaemic conditions in the complex pathogenesis of lipid and glucose metabolism [ 49 ]. These two observations prompted us to assess the effect of COE on lipid-lowering properties in EAC and doxorubicin-induced hyperlipidaemia [ 50 , 51 ]. COE alone and in combination with doxorubicin significantly reversed the altered parameters, viz., HDL, cholesterol, and triglycerides, which reflected the shielding role of COE against hyperlipidaemia, which, in turn, prevented cardiac injury and preserved cardiac function.…”

Novel pyrrolopyrimidine derivatives: design, synthesis, molecular docking, molecular simulations and biological evaluations as antioxidant and anti-inflammatory agents

“…In early responses to inflammation, specific damage-associated molecular patterns are recognised by immune cell pattern recognition receptors (PRRs), including toll-like receptors (TLRs), pattern recognition receptors (PRR) recognise pathogen-associated molecular patterns (PAMPs) 73–75 . TLR-4 can be also activated by damage-associated molecular patterns (DAMPs) and endogenous agonists released by injured tissues and necrotic cells 76–82 . TLR4-mediated inflammation, triggered by DAMPs, is involved in several diseases such as sepsis.…”

Application of natural antioxidants from traditional Chinese medicine in the treatment of spinal cord injury

“…It can be used to produce functional products and as an anti-aging cosmetic agent for the skin ( Fagot et al, 2018 ). Despite being used in dermatology, the results of Abdulkareem Aljumaily et al (2021) verified that it can be used as a heart-protective agent for patients with cancers.…”