Antioxidant, anti-inflammatory, and anti-allergic activities of the sweet-tasting protein brazzein

Chung, Ju-Hee; Kong, Ji-Na; Choi, Hyo-Eun; Kong, Kwang-Hoon

doi:10.1016/j.foodchem.2017.06.084

Cited by 31 publications

(26 citation statements)

References 34 publications

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“…In several African countries, natural products constitute an important part of human diet and are also an excellent source of bioactive molecules. First plant of medicinal interest of the current study, Hibiscus sabdariffa, is an edible plant, for which previous studies on alcoholic and aqueous extracts from its calyx reported anti‐inflammatory, antioxidant, hypolipidemic (Chung, Kong, Choi, & Kong, ; Medina‐Carrillo et al, ), and anti‐hypertensive effects (Abubakar, Ukwuani, & Mande, ), owing to its wealth of bioactive compounds (polyphenols, flavonoids, saponins, tannins, alkaloids, etc.). Then, it has also been showed that the aqueous, alcoholic, and hydroalcoholic extracts of the fruits of Dichrostachys glomerata , which is the second plant of medicinal interest of the study, exhibit antioxidant (Kuate, Etoundi, Soukontoua, Ngondi, & Oben, ), anti‐hypertensive, hypoglycemic (Fankam, Kuete, Voukeng, Kuiate, & Pages, ), anti‐inflammatory, and anti‐hyperlipidemic activities (Kuate et al, ); these numerous biological activities were attributed to their contents in a broad range of bioactive molecules such as alkaloids, saponins, tannins, mucilage, glucocapparins, and sterols.…”

Section: Introductionmentioning

confidence: 97%

Successive grinding and sieving as a new tool to fractionate polyphenols and antioxidants of plants powders: Application to Boscia senegalensis seeds, Dichrostachys glomerata fruits, and Hibiscus sabdariffa calyx powders

Deli

Ndjantou

Metsagang

et al. 2019

Food Science & Nutrition

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The present investigation aimed at evaluating the effect of powder fractionation based on particle size on the chemical composition in macronutrients, polyphenol contents, and antioxidant properties of powders of Boscia senegalensis seeds, Dichrostachys glomerata fruits, and Hibiscus sabdariffa calyces. Significant differences ( p < 0.05) among granulometric classes of each plant were observed for the chemical composition in macronutrients. A decrease in particle size of plant powders was associated with an increase in ash, protein, and fat contents, while carbohydrate content was lowered. The following Granulometric classes, [0–180 µm] for Boscia senegalensis , [180–212 µm] for Dichrostachys glomerata, and [212–315 µm] for Hibiscus sabdariffa, respectively, were found to maximize total phenolic content and antioxidant activity. These results confirm that the grinding and controlled differential screening technology is an approach may serve as a useful guide to obtain optimum polyphenol extraction and enhance antioxidant activity of plant products .

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Section: Introductionmentioning

confidence: 97%

Successive grinding and sieving as a new tool to fractionate polyphenols and antioxidants of plants powders: Application to Boscia senegalensis seeds, Dichrostachys glomerata fruits, and Hibiscus sabdariffa calyx powders

Deli

Ndjantou

Metsagang

et al. 2019

Food Science & Nutrition

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“…Therefore, researchers are looking for new compounds, also food components, with a potent anti-inflammatory effect involved in inhibition of selected enzymes in the human organism. There are many studies focused on the plant protein as a source of peptides with anti-inflammatory activity (Chung, Kong, Choi, & Kong, 2018;González-Montoya, Hernández-Ledesma, Silván, Mora-Escobedo, & Martínez-Villaluenga, 2018;Kim et al, 2018;Montoya-Rodríguez & de Mejía, 2015). The anti-inflammatory mechanism of these peptides is based on the inhibition of activity of enzymes involved in the inflammatory process such as LOX, COX-1, COX-2 or inhibition of the secretion of inflammatory markers (nitric oxide, TNF-α, IL-1β, and IL-6) by macrophages.…”

Section: Introductionmentioning

confidence: 99%

Potential anti-inflammatory and lipase inhibitory peptides generated by in vitro gastrointestinal hydrolysis of heat treated millet grains

Jakubczyk

Szymanowska

Karaś

et al. 2019

CyTA - Journal of Food

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The influence of heat treatment (65°C and 100°C) on the activities of potential anti-inflammatory peptides obtained from a millet protein fraction was investigated. The molecular mass of proteins was found to be in the range of 6.5-100 kDa. The protein fractions were in vitro hydrolyzed in gastrointestinal-like conditions. The highest peptide content was noted for albumin in the control sample (2.03 mg/mL). The peptide fraction obtained from globulin 7S derived from grains heated at 65°C was characterized by the highest COX-1 and COX-2 inhibitory activity (IC 50 = 0.08 and 0.12 mg/mL, respectively). The peptide fraction obtained from the prolamin treatment at 100°C exhibited the highest LOX inhibitory activity (IC 50 = 0.14 mg/mL). Peptides from the prolamin treatment at 65°C were characterized by the highest pancreatic lipase inhibitory activity (IC 50 = 0.03 mg/mL). Peptide fractions with highest anti-inflammatory activity were rich in Gly. Posibles péptidos antiinflamatorios e inhibidores de la lipasa generados por hidrólisis gastrointestinal in vitro de granos de mijo tratados térmicamente RESUMEN Se investigó la influencia del tratamiento con calor (65°C y 100°C) en la actividad de posibles péptidos antiinflamatorios obtenidos de una fracción de proteína de mijo. Al respecto, se constató que la masa molecular de las proteínas estaba en el rango de 6.5-100 kDa. Las fracciones de proteínas se hidrolizaron in vitro en condiciones similares a las gastrointestinales. La albúmina de la muestra de control exhibió el mayor contenido de péptidos (2.03 mg/ml). La fracción peptídica obtenida de la globulina 7S derivada de granos calentados a 65°C presentó la actividad inhibidora de COX-1 y COX-2 más alta (IC 50 = 0.08 y 0.12 mg/mL, respectivamente). La fracción peptídica obtenida del tratamiento con prolamina a 100°C mostró la mayor actividad inhibidora de LOX (IC 50 = 0.14 mg/mL). Los péptidos del tratamiento con prolamina a 65°C exhibieron la actividad inhibidora de la lipasa pancreática más alta (IC 50 = 0.03 mg/mL). Las fracciones peptídicas con mayor actividad antiinflamatoria mostraron abundante Gly.

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“…ABTS + scavenging ability was evaluated according to the antioxidant method of Chung et al [50] with some modifications. A 6 mmol/L ABTS solution in 95% ethanol and 120 mmol/L of potassium persulfate water solution were fully mingled, incubated overnight under the darkened condition to produce ABTS + .…”

Section: Methodsmentioning

confidence: 99%

Ionic Liquid–Ultrasound-Based Extraction of Biflavonoids from Selaginella helvetica and Investigation of Their Antioxidant Activity

Jiang

et al. 2018

Molecules

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As a new and green solvent, ionic liquids (ILs) have received more attention during the green extraction and separation process for natural medicines. In this paper, IL-ultrasound-assisted extraction (IL-UAE) of total biflavonoids (TBFs) from Selaginella helvetica was firstly developed, and different ILs were employed and compared. Based on single-factor experiment, solid–liquid ratio (1:10–1:14 g/mL), IL concentration (0.6–1.0 mmol/mL), and extract temperature (40–60 °C) were further explored, according to response surface methodology (RSM), with TBF yields as the index. Moreover, antioxidant activity of TBF extract was analyzed by four methods, i.e., 2,2-di(4-tert-octylphenyl)-1-picrylhydrazyl (DPPH) and 2,2′-azinobis-(3-ethylbenzth-iazoline-6-sulphonate (ABTS) free radical scavenging assay, ferric ion reducing power assay, and chelation of ferrous ions assay. The results indicated that [C6mim]PF6 had a high selectivity and efficiency. Moreover, important parameters for the extraction process were investigated and optimized. Through parameter optimization (0.8 mmol/L, 250 W, 40 min, 1:12.7 g/mL, and 47 °C), a yield of 18.69 mg/g biflavonoids was obtained from the extract of S. helvetica. Compared with ethanol-UAE, heat-reflux extraction, Soxhlet extraction, and percolation extraction, IL-UAE could not only obtain higher yield in a shorter time, but also reduce the solvent consumption. In addition, TBF extract showed potential antioxidant activity based on the above four antioxidant methods. In short, IL-UAE was first employed to develop a novel and green extraction method for TBF content, and this experiment provides valuable references for further utilization of S. helvetica.

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Antioxidant, anti-inflammatory, and anti-allergic activities of the sweet-tasting protein brazzein

Cited by 31 publications

References 34 publications

Successive grinding and sieving as a new tool to fractionate polyphenols and antioxidants of plants powders: Application to Boscia senegalensis seeds, Dichrostachys glomerata fruits, and Hibiscus sabdariffa calyx powders

Successive grinding and sieving as a new tool to fractionate polyphenols and antioxidants of plants powders: Application to Boscia senegalensis seeds, Dichrostachys glomerata fruits, and Hibiscus sabdariffa calyx powders

Potential anti-inflammatory and lipase inhibitory peptides generated by in vitro gastrointestinal hydrolysis of heat treated millet grains

Ionic Liquid–Ultrasound-Based Extraction of Biflavonoids from Selaginella helvetica and Investigation of Their Antioxidant Activity

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