Antioxidant and α-glucosidase inhibitory activities of Murraya koenigii leaf extracts

Abstract

Medicinal plants are source for a wide variety of natural antioxidants. Dietary antioxidant consumption may be an important approach for inhibiting or delaying the oxidation of susceptible cellular substrates and thus is relevant to disease prevention in many paradigms. Murraya koenigii is one of the important medicinal herb which is used as a food ingredient across India. In this study, we demonstrated the reducing power, total antioxidant potential, radical scavenging capabilities and α-glycosidase inhibitory property of different crude extracts of curry leaves (Murraya koenigii L.). The extracts were evaluated for their radical scavenging activities by means of DPPH, NO, • OH, O2 − and anti-lipid peroxidation assays. In addition, extract of M. koenigii were tested for α-glycosidase inhibitory property. The extracts of M. koenigii scavenged radicals effectively in varied degree. Similarly, the total reducing power of alcohol extract was found higher in both phosphomolybednum and FRAP methods. In vitro assay of α-glucosidase activity of MKA and MKW showed an IC 50 of 174.74 and 287.00 μg/ml respectively, while other two extracts did not show any significant effect. Simultaneously, total phenolic and total flavonoid contents of extracts were studied, where values of MKW were found to be higher than that of other extracts. In present study, we found that MKA and MKW extracts contain effective antioxidant and radical scavenging activities as compared to other extracts. Our study provides a proof for the ethno-medical claims and reported biological activities that curry leaves have significant therapeutic potential.

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

“…It has also been shown that Murrya koenigii exerts insulin sensitizing and antioxidant activities, besides its α-glucosimidase inhibitory activity that can aid in glycemic control. 76 , 77 Ocimun tenuiflorum leaves are traditionally used in diabetes in Malaysia. Investigation on the hypoglycemic effects of O. tenuiflorum extract revealed preventing of hepatic gluconeogenesis as well as activation of glucose uptake in adipose tissues and skeletal muscle.…”

In VitroAntioxidant, Antiproliferative, and Phytochemical Study in Different Extracts ofNyctanthes arbortristisFlowers

“…The natural products symbolize safety in contrast to the synthetic drugs, but still there is need to check their efficacy with systematic studies. Therefore, the need for new therapeutic options has prompted many researchers to evaluate the efficacy of compounds found in natural products [ 12 ].…”

Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds

“…M. koenigii was tested for the α-glucosidase inhibitory property and was found to inhibit α glycosidase. Alpha-glucosidase inhibitors are widely used in the treatment of patients with type 2 diabetes [113]. A study reported that an ethanolic extract of M. koenigii showed a significant reduction in blood glucose levels, and this effect of reducing blood glucose by M. koenigii is mediated by antioxidant properties and insulin mimetic effects.…”