Antioxidant and Radical Scavenging Activity of Human Colostrum, Transitional and Mature Milk

Zarban, Asghar; Taheri, Fatemeh; Chahkandi, Tayyebeh; Sharifzadeh, Gholamreza; Khorashadizadeh, Mohsen

doi:10.3164/jcbn.08-233

Cited by 121 publications

(110 citation statements)

References 28 publications

(32 reference statements)

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“…On the other hand, antioxidant power which was measured by the bivalent-iron reduction method was higher in colostrum than in breastmilk in the other lactational periods. The same result was obtained by DPPH radical scavenging activity [24]. High level of antioxidant potential in colostrum may alleviate the oxidative stress of newborns with an immature antioxidative defense mechanism and then contribute to the growth and development of those newborns.…”

Section: Discussionsupporting

confidence: 69%

“…It was also reported that when antioxidant potential was measured by using the ABTS radical method, there was a positive correlation between antioxidant components in breastmilk and the antioxidant status of mothers and newborns [26]. Moreover, a study that evaluated maternal antioxidant status and antioxidant potential of breastmilk using the FRAP method also revealed a significant correlation between them [24]. Our study, too, revealed a correlation between maternal antioxidant status and antioxidant potential of breastmilk.…”

Section: Discussionmentioning

confidence: 66%

“…Moreover, the BAP levels in breastmilk at 3 months after giving birth, which started to decrease gradually in the early puerperium period, turned out to be about 1.5 times higher than maternal BAP levels. It was pointed out that the antioxidant substance levels in breastmilk were about 2 times higher than those in maternal plasma [26], while it was reported that the average antioxidant potential of breastmilk at 3 months after giving birth was almost close to that of maternal plasma [24]. Given that antioxidant potential of breastmilk is higher in mature milk than in colostrum or transitional milk, it can be assumed that antioxidant potential is higher in breastmilk than in maternal plasma until 3 months after giving birth.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Oxidative Stress, Antioxidant Power, and Antioxidant Potential of Breastmilk of Breast-Feeding Mothers

Kuramoto¹,

Kitagawa²

2017

Health

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Purpose: The purpose of this study was to evaluate oxidative stress, antioxidant power, and antioxidant potential of breastmilk of breast-feeding mothers from the early postpartum period to the first 3 months postpartum, and to examine the dynamics and the relationships among them. Method: For 47 puerperant women who gave vaginal birth without any pregnancy complications, the oxidative stress levels (d-ROMs levels) and antioxidant power (BAP levels) in the maternal plasma as well as antioxidant potential of breastmilk (BAP levels in breastmilk) were measured 3 times, i.e., in the early puerperium (4 or 5 days after giving birth), one month after giving birth, and 3 months after giving birth. Results: The d-ROMs levels in the maternal plasma were significantly high in the early puerperium (p < 0.001), and decreased gradually in the postpartum period (p < 0.001). On the other hand, BAP levels were significantly low in the early puerperium (p < 0.001), and increased to the almost normal level during one month after giving birth. BAP levels in breastmilk were significantly high in the early puerperium compared with the other periods (p < 0.001), and decreased gradually until 3 months after giving birth (p < 0.001). BAP levels in breastmilk in the early puerperium were higher compared with the maternal BAP levels, and there was a positive correlation between BAP levels in breastmilk and those in the maternal plasma (p < 0.05). Discussion: Regarding the oxidative stress and the antioxidant defense system of breast-feeding mothers, the d-ROMs level was highest and the BAP level was lowest in the early puerperium. The BAP level then showed a clear tendency to recover in the first 3 months after giving birth. Conclusion: When the maternal antioxidant potential remains at a low level after giving birth, careful consideration should be given to the mother's health and wellbeing How to cite this paper:

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Oxidative Stress, Antioxidant Power, and Antioxidant Potential of Breastmilk of Breast-Feeding Mothers

Kuramoto¹,

Kitagawa²

2017

Health

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“…The scavenging capacity of DPPH was measured using the method proposed by Brand-Williams et al [12] with modifications proposed by Zarban et al [13], 50 μL of each HM sample was added with 1 mL DPPH in ethanol solution (0.06 mM). After homogenization, the mixture was allowed to stand for 30 minutes in a water bath at 37°C.…”

Section: Methodsmentioning

confidence: 99%

Stability of Antioxidant Capacity of Human Milk after Freezing and Pasteurization

Nogueira¹,

Santos²,

Passos³

et al. 2018

JFNR

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Pasteurization and freezing are processes used in human milk banks that can affect some of the nutritional and biological properties of human milk. The aim of this study was to evaluate impact of the processing steps adopted by human milk banks on the contents of total phenolic compounds and antioxidant capacity in vitro. Experimental study was realized, in which 40 mL human milk were collected from 8 mothers registered at the Human Milk Bank of Ouro Preto, state of Minas Gerais. Samples were homogenized to form the pool. Human milk was divided into four portions that characterized the treatments: 1) immediately after milking; 2) pasteurization soon after the milking; 3) 7 days after freezing at -8.5 (± 2.8°C) and pasteurized; 4) 14 days after freezing at -8.5 (± 2.8°C) and pasteurized. The content of total phenolic compounds was determined, and the antioxidant capacity was assessed using the 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) and 2,2-diphenyl-1-picrylhydrazyl free radicals scavenging. The results were expressed as mean and standard deviation of six replications. There was a positive correlation between the evaluated methods and reduction in total phenolic content and total antioxidant capacity with slow pasteurization and according to freezing time. There was a negative effect of pasteurization and freezing on the total phenolic content and total antioxidant capacity, and the most significant reduction was observed within the first 7 days of storage.

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“…Some studies are based on the evaluation of antioxidant potential of HM [16] and CM [17], but little is known about the MM potential and the effect of period of lactation on it.…”

mentioning

confidence: 99%

Fatty Acid Composition, Fat Globule Size and Reactive Oxygen Species-Scavenging Activity of Mare Milk: A Longitudinal Study

Faustini¹

2014

JDVAR

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Antioxidant and Radical Scavenging Activity of Human Colostrum, Transitional and Mature Milk

Cited by 121 publications

References 28 publications

Evaluation of Oxidative Stress, Antioxidant Power, and Antioxidant Potential of Breastmilk of Breast-Feeding Mothers

Evaluation of Oxidative Stress, Antioxidant Power, and Antioxidant Potential of Breastmilk of Breast-Feeding Mothers

Stability of Antioxidant Capacity of Human Milk after Freezing and Pasteurization

Fatty Acid Composition, Fat Globule Size and Reactive Oxygen Species-Scavenging Activity of Mare Milk: A Longitudinal Study

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