Antioxidant and Pro-Oxidant Effects of Polyphenolic Compounds and Structure-Activity Relationship Evidence

Yordi, Estela Guardado; Pérez, Enrique Molina; Matos, María Joäo; Villares, Eugenio Uriarte

doi:10.5772/29471

Cited by 37 publications

(28 citation statements)

References 116 publications

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“…Notably, the concentration of the compounds determines their antioxidant or pro-oxidant activity. Pro-oxidant activity can induce damage to biomolecules such as DNA, lipids, or proteins (Fukumoto and Mazza 2000;Yordi et al 2012). Potential antioxidants should therefore be tested for their pro-oxidant activity also.…”

Section: Discussionmentioning

confidence: 99%

Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing

Bağdaş

Gül

Topal

et al. 2014

Naunyn-Schmiedeberg's Arch Pharmacol

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Chlorogenic acid (CGA) is a well-known natural antioxidant in human diet. To understand the effects of CGA on wound healing by enhancing antioxidant defense in the body, the present study sought to investigate the potential role of systemic CGA therapy on wound healing and oxidative stress markers of the skin. We also aimed to understand whether chronic CGA treatment has side effects on pivotal organs or rat bone marrow during therapy. Full-thickness experimental wounds were created on the backs of rats. CGA (25, 50, 100, 200 mg/kg) or vehicle was administered intraperitoneally for 15 days. All rats were sacrificed on the 16th day. Biochemical, histopathological, and immunohistochemical examinations were performed. Possible side effects were also investigated. The results suggested that CGA accelerated wound healing in a dose-dependent manner. CGA enhanced hydroxyproline content, decreased malondialdehyde and nitric oxide levels. and elevated reduced glutathione, superoxide dismutase, and catalase levels in wound tissues. Epithelialization, angiogenesis, fibroblast proliferation, and collagen formation increased by CGA while polymorph nuclear leukocytes infiltration decreased. CGA modulated matrix metalloproteinase-9 and tissue inhibitor-2 expression in biopsies. Otherwise, high dose of CGA increased lipid peroxidation of liver and kidney without affecting the heart and muscle samples. Chronic CGA increased micronuclei formation and induced cytotoxicity in the bone marrow. In conclusion, systemic CGA has beneficial effects in improving wound repair. Antioxidant, free radical scavenger, angiogenesis, and anti-inflammatory effects of CGA may ameliorate wound healing. High dose of CGA may induce side effects. In light of these observations, CGA supplementation or dietary CGA may have benefit on wound healing.

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Section: Discussionmentioning

confidence: 99%

Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing

Bağdaş

Gül

Topal

et al. 2014

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Polyphenols can further act by inhibiting cell proliferation, which is deregulated in cancer. This inhibition has been demonstrated in vitro in many tumor cell lines [43]. PCNA is a well-known marker for detection of cell proliferation and overexpression of PCNA indicates assessment of tumor progression [2].…”

Section: Effect Of Hsp and Hspnps On Cell Proliferationmentioning

confidence: 99%

Comparative evaluation of hesperetin loaded nanoparticles for anticancer activity against C6 glioma cancer cells

Ersöz

Erdemir

Duranoğlu

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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The aim of this study was to evaluate anti-cancer properties of hesperetin (Hsp) and hesperetin-loaded poly(lactic-co-glycolic acid) nanoparticles (HspNPs) for glioblastoma treatment. Nanoparticles prepared by single emulsion method had a size of less than 300 nm with 70.7 ± 3.9% reaction yield and 26.4 ± 1.1% Hsp loading capacity. Treatment of C6 glioma cells with HspNPs for 24 and 48 h resulted in dose-and time-dependent decrease in cell viability, with approximate IC 50 of 28 and 21 lg/mL, respectively (p ¼ .036 for 24 h, p ¼ .025 for 48 h). The percentage of PCNA positive cells decreased to 20% and 10%, respectively, for Hsp-and HspNP-treated cells at concentration of 100 mg/mL. Treatment with increasing concentrations of HspNPs (25, 50, 75 and 100 mg/mL) resulted in 9.1-, 7-, 12.5-and 12.7-fold in increase in apoptotic cell number. Optimum doses of Hsp and HspNPs were found to increase oxidative damage in C6 glioma cells. MDA levels, an indicator of lipid peroxidation, were found to be significantly elevated at 75 and 100 mg/mL exposure concentration of HspNPs with (p ¼ .002) and (p ¼ .018), respectively for 48-h treatment. The results obtained with this study showed biocompatible polymeric nanoparticle systems has great advantages to enhance anti-cancer activity and poor solubility of therapeutic agents. Overall our findings suggest that Hsp-loaded PLGA nanoparticle systems showed significant anti-cancer activity and HspNPs could be used as promising novel anti-cancer agent. ARTICLE HISTORY

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“…A study from Oregon (Portland), with 369 isolates (during the year 1995 to 1998) showed that the isolates were resistant to ampicillin (63%) and co-trimoxazole (59%). Thirteen percent of the isolates were resistant to all the five drugs ampicillin, chloramphenicol, streptomycin, sulfisoxazole and tetracycline [85]. In another study from Foodborne Disease Active Surveillance Network sites, out of 1118 isolates from the year 2000 to 2010, 74% isolates were found resistant to ampicillin, 58% to streptomycin, 36% to co-trimoxazole and 28% to tetracycline [86].…”

Section: Drug Resistance In Shigellamentioning

confidence: 97%

“…Polyphenols such as vanillic acid, rutin, tannic acid, protocatechuic acid; carotenoids like β-carotene, linoleic acid, zeaxanthin, lutein; and flavonoids viz. quercetin, catechin, kaempferol, tocopherol do possess free radical scavenging antioxidant properties [83][84][85].…”

Section: Ros Generators As Modulators Of Virulencementioning

confidence: 99%

Resistance to Antibiotics: Are we prepared to Handle This Growing Ghost?

Bhardwaj¹

2017

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Antioxidant and Pro-Oxidant Effects of Polyphenolic Compounds and Structure-Activity Relationship Evidence

Cited by 37 publications

References 116 publications

Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing

Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing

Comparative evaluation of hesperetin loaded nanoparticles for anticancer activity against C6 glioma cancer cells

Resistance to Antibiotics: Are we prepared to Handle This Growing Ghost?

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