Antioxidant and prebiotic potential of Murraya koenigii and Brassica oleracea var. botrytis leaves as food ingredient

Bhatt, Shriya; B, Singh; Gupta, Mahesh

doi:10.1016/j.jafr.2020.100069

Cited by 21 publications

(16 citation statements)

References 27 publications

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“…Total flavonoid content was determined as described earlier ( Bhatt et al, 2020 ). Briefly, the extracts were mixed with sodium nitrite (5%) and aluminum chloride and reacted with sodium hydroxide (1 N).…”

Section: Methodsmentioning

confidence: 99%

Pomegranate Peel Extract Decreases Plaque Necrosis and Advanced Atherosclerosis Progression in Apoe-/- Mice

et al. 2022

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Atherosclerosis is a chronic lipid-driven inflammatory condition of the arteries and is a leading cause of stroke, myocardial infarction, and other peripheral arterial diseases. Plant products rich in polyphenols such as pomegranate juice and peel extract are known to have beneficial effects in suppressing atherogenesis. However, the mechanism of action and its effect on advanced atherosclerosis progression which results in adverse clinical outcomes are not well understood. Herein, we use a standardized hydroethanolic extract of Punica granatum (pomegranate) peel in the Apoe-/- a murine model of advanced atherosclerosis. It was observed that the pomegranate peel extract fed mice have decreased plaque necrosis and elevated lesional collagen content which was associated with a favorable metabolic profile including lowering of blood glucose, cholesterol, and triglyceride. The decrease in plaque necrosis was linked with increased lesional macrophage efferocytosis efficiency which was associated with enhanced expression of the efferocytosis receptor Mertk. Using in vitro studies, we show that pomegranate peel extract blocks the shedding of Mertk and preserves macrophage efferocytosis efficiency. These data identify a novel mechanism by which pomegranate peel extract promotes the resolution of inflammation in atherosclerosis.

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Section: Methodsmentioning

confidence: 99%

Pomegranate Peel Extract Decreases Plaque Necrosis and Advanced Atherosclerosis Progression in Apoe-/- Mice

et al. 2022

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“…In addition to anti-inflammatory potential, Brassicaceae can also present antioxidant potential. Numerous in vitro assays, such as: 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) radical scavenging capacity assay [ 36 , 59 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ]; 2-20-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS)-radical scavenging capacity assay; Ferric-reducing antioxidant power assay (FRAP) [ 58 , 79 , 80 , 81 ] or oxygen radical absorbance capacity (ORAC) assay [ 82 , 83 ] demonstrated that extracts from various components of the Brassicaceae family, as broccoli, cabbages and cauliflowers have also high antioxidant power. In cellular models, Brassicaceae has been reported to inhibit iNOS expression and function, and thereby NO production [ 62 ].…”

Section: Brassicaceae and Inflammation: Evidence Of Anti-inflammatory...mentioning

confidence: 99%

Anti-Inflammatory Potential of Brassicaceae-Derived Phytochemicals: In Vitro and In Vivo Evidence for a Putative Role in the Prevention and Treatment of IBD

2022

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Inflammatory bowel disease (IBD) is a group of intestinal disorders, of unknown etiology, characterized by chronic inflammation within the gut. They are gradually becoming critical because of the increasing incidence worldwide and improved diagnosis. Due to the important side effects observed during conventional therapy, natural bioactive components are now under intense investigation for the prevention and treatment of chronic illnesses. The Brassicaceae family comprises vegetables widely consumed all over the world. In recent decades, a growing body of literature has reported that extracts from the Brassicaceae family and their purified constituents have anti-inflammatory properties, which has generated interest from both the scientific community and clinicians. In this review, data from the literature are scrutinized and concisely presented demonstrating that Brassicaceae may have anti-IBD potential. The excellent biological activities of Brassicacea are widely attributable to their ability to regulate the levels of inflammatory and oxidant mediators, as well as their capacity for immunomodulatory regulation, maintenance of intestinal barrier integrity and intestinal flora balance. Possible future applications of bioactive-derived compounds from Brassicaceae for promoting intestinal health should be investigated.

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“…The aqua‐ethanolic extracts of Brassica oleracea were added to the media for observing the growth of probiotics strains (lactobacilli). After an incubation of 24 h, all the strains of lactobacilli ( Lactobacillus sakei , Lactobacillus rhamnosus , and Lactobacillus casei ) displayed higher growth in comparison to growth under the presence of control (glucose) experiment (Bhatt, Singh, & Gupta, 2020). Considering the beneficial effects of the extracts of the leaves of the B. oleracea as a prebiotic in human gut, these extracts can be useful in the development of the innovative functional products.…”

Section: Clinical Effectiveness Of Brassica Plants In Humanmentioning

confidence: 99%

Phytotherapy and food applications from Brassica genus

Salehi

Quispe

Butnariu

et al. 2021

Phytotherapy Research

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Plants of the genus Brassica occupy the top place among vegetables in the world. This genus, which contains a group of six related species of a global economic significance, three of which are diploid: Brassica nigra (L.) K. Koch, Brassica oleracea L., and Brassica rapa L. and three are amphidiploid species: Brassica carinata A. Braun, Brassica juncea (L.) Czern., and Brassica napus L. These varieties are divided into oily, fodder, spice,

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Antioxidant and prebiotic potential of Murraya koenigii and Brassica oleracea var. botrytis leaves as food ingredient

Cited by 21 publications

References 27 publications

Pomegranate Peel Extract Decreases Plaque Necrosis and Advanced Atherosclerosis Progression in Apoe-/- Mice

Pomegranate Peel Extract Decreases Plaque Necrosis and Advanced Atherosclerosis Progression in Apoe-/- Mice

Anti-Inflammatory Potential of Brassicaceae-Derived Phytochemicals: In Vitro and In Vivo Evidence for a Putative Role in the Prevention and Treatment of IBD

Phytotherapy and food applications from Brassica genus

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